PMID- 31758424
OWN - NLM
STAT- MEDLINE
DCOM- 20201119
LR  - 20220307
IS  - 1434-9949 (Electronic)
IS  - 0770-3198 (Linking)
VI  - 39
IP  - 2
DP  - 2020 Feb
TI  - Comparative analysis of connective tissue disease-associated interstitial lung 
      disease and interstitial pneumonia with autoimmune features.
PG  - 575-583
LID - 10.1007/s10067-019-04836-3 [doi]
AB  - OBJECTIVE: This retrospective clinical study aimed to examine the similarities 
      and differences between connective tissue disease-associated interstitial lung 
      disease (CTD-ILD) and interstitial pneumonia with autoimmune features (IPAF) and 
      to identify the influencing factors of CTD-ILD, with a goal of early detection 
      and active treatment of the disease. METHODS: We conducted a retrospective study 
      of 480 patients: 412 with CTD-ILD and 68 with IPAF. Demographic features, 
      clinical characteristics, laboratory indicators, and chest high-resolution 
      computed tomography (HRCT) imaging data were analyzed. RESULTS: Compared with the 
      IPAF group, the CTD-ILD group contained more women, and the incidences of joint 
      pain, dry mouth/dry eyes, and Raynaud's phenomenon were higher; erythrocyte 
      sedimentation rate (ESR) and D-dimer levels were higher; red blood cell (RBC) and 
      hemoglobin (Hb) levels were lower; a high rheumatoid factor (RF) titer (> 2 times 
      the normal upper limit) was observed, and anti-cyclic citrullinated peptide 
      antibody (anti-CCP), anti-keratin antibody (AKA), antinuclear antibody (ANA), and 
      anti-melanoma differentiation-associated gene 5 antibody (anti-MDA5) levels were 
      higher. Compared with CTD-ILD patients, IPAF patients were more likely to present 
      initially with respiratory symptoms, with higher rates of fever, cough and 
      expectoration, dyspnea, and Velcro crackles; anti-Ro52 titers were higher; 
      incidences of honeycombing opacity, reticulate opacity, patchy opacity, and 
      pleural thickening were greater. Female sex, a high RF titer (> 2 times the 
      normal upper limit), anti-CCP positivity, ANA positivity, and anti-MDA5 
      positivity were risk factors for CTD-ILD when the odds ratios were adjusted. 
      CONCLUSION: CTD-ILD and IPAF patients differed in demographic features, clinical 
      characteristics, laboratory indicators, and chest HRCT imaging data. Female sex, 
      a high RF titer (> 2 times the normal upper limit), anti-CCP positivity, ANA 
      positivity, and anti-MDA5 positivity were risk factors for CTD-ILD.Key Points* 
      This retrospective clinical study comprehensively compared the demographic 
      features, clinical characteristics, laboratory indicators, and chest HRCT imaging 
      data of CTD-ILD and IPAF patients.* The evidence suggested that female sex, a 
      high RF titer, anti-CCP positivity, ANA positivity, and anti-MDA5 positivity were 
      risk factors for CTD-ILD.
FAU - Tian, Mengxue
AU  - Tian M
AD  - Department of Rheumatology and Immunology, The Second Affiliated Hospital of 
      Chongqing Medical University, 76 Linjiang Road, Chongqing, 400010, China.
FAU - Huang, Wenhan
AU  - Huang W
AD  - Department of Rheumatology and Immunology, The Second Affiliated Hospital of 
      Chongqing Medical University, 76 Linjiang Road, Chongqing, 400010, China.
FAU - Ren, Feifeng
AU  - Ren F
AD  - Department of Rheumatology and Immunology, The Second Affiliated Hospital of 
      Chongqing Medical University, 76 Linjiang Road, Chongqing, 400010, China.
FAU - Luo, Lei
AU  - Luo L
AD  - Department of Rheumatology and Immunology, The Second Affiliated Hospital of 
      Chongqing Medical University, 76 Linjiang Road, Chongqing, 400010, China.
FAU - Zhou, Jun
AU  - Zhou J
AD  - Department of Rheumatology and Immunology, The Second Affiliated Hospital of 
      Chongqing Medical University, 76 Linjiang Road, Chongqing, 400010, China.
FAU - Huang, Dongmei
AU  - Huang D
AD  - Department of Rheumatology and Immunology, The Second Affiliated Hospital of 
      Chongqing Medical University, 76 Linjiang Road, Chongqing, 400010, China.
FAU - Tang, Lin
AU  - Tang L
AUID- ORCID: 0000-0002-6406-9563
AD  - Department of Rheumatology and Immunology, The Second Affiliated Hospital of 
      Chongqing Medical University, 76 Linjiang Road, Chongqing, 400010, China. 
      tanglin1217@163.com.
LA  - eng
GR  - grant No. 81771738/National Natural Science Foundation of China/
PT  - Comparative Study
PT  - Journal Article
DEP - 20191122
PL  - Germany
TA  - Clin Rheumatol
JT  - Clinical rheumatology
JID - 8211469
RN  - 0 (Autoantibodies)
SB  - IM
MH  - Aged
MH  - Autoantibodies/blood
MH  - Connective Tissue Diseases/blood/*complications/diagnostic imaging
MH  - Diabetes Mellitus, Type 1/blood/*complications/diagnostic imaging
MH  - Diagnosis, Differential
MH  - Female
MH  - Humans
MH  - Lung Diseases, Interstitial/blood/diagnostic imaging/*etiology
MH  - Male
MH  - Middle Aged
MH  - Radiography, Thoracic
MH  - Retrospective Studies
MH  - Tomography, X-Ray Computed
OTO - NOTNLM
OT  - Autoantibodies
OT  - Connective tissue disease
OT  - Interstitial lung disease
OT  - Interstitial pneumonia with autoimmune features
OT  - Rheumatic immune disease
EDAT- 2019/11/24 06:00
MHDA- 2020/11/20 06:00
CRDT- 2019/11/24 06:00
PHST- 2019/07/09 00:00 [received]
PHST- 2019/10/31 00:00 [accepted]
PHST- 2019/09/29 00:00 [revised]
PHST- 2019/11/24 06:00 [pubmed]
PHST- 2020/11/20 06:00 [medline]
PHST- 2019/11/24 06:00 [entrez]
AID - 10.1007/s10067-019-04836-3 [pii]
AID - 10.1007/s10067-019-04836-3 [doi]
PST - ppublish
SO  - Clin Rheumatol. 2020 Feb;39(2):575-583. doi: 10.1007/s10067-019-04836-3. Epub 
      2019 Nov 22.