PMID- 31758432
OWN - NLM
STAT- MEDLINE
DCOM- 20201109
LR  - 20201109
IS  - 1573-2568 (Electronic)
IS  - 0163-2116 (Linking)
VI  - 65
IP  - 7
DP  - 2020 Jul
TI  - Different Hepatitis C Virus Infection Statuses Show a Significant Risk of 
      Developing Type 2 Diabetes Mellitus: A Network Meta-Analysis.
PG  - 1940-1950
LID - 10.1007/s10620-019-05918-7 [doi]
AB  - BACKGROUND: The role of hepatitis C virus (HCV) infection statuses in the 
      development of type 2 diabetes mellitus (T2DM) has not been completely 
      understood. AIM: To evaluate the prevalence of T2DM in patients with different 
      HCV infection statuses. METHODS: We conducted a systematic study on T2DM risk in 
      five types of individuals with different HCV infection statuses: non-HCV 
      controls, HCV-cleared patients, chronic HCV patients without cirrhosis, patients 
      with HCV cirrhosis and patients with decompensated HCV cirrhosis. Studies 
      published from 2010 to 2019 were selected. Both pairwise and network 
      meta-analyses were employed to compare the T2DM risk among patients with 
      different HCV infection statuses. RESULTS: The pairwise meta-analysis showed that 
      non-HCV (OR = 0.60, 95% CI [0.47-0.78]) had a lower risk of T2DM compared with 
      CHC, while cirrhosis had a significant higher risk (OR = 1.90, 95% CI 
      [1.60-2.26]). Network meta-analysis further demonstrated patients with HCV 
      infection were at a significantly higher risk of T2DM than those without HCV 
      infection or with HCV clearance, while decompensated cirrhosis had a significant 
      higher T2DM risk than non-HCV (OR = 3.84, 95% CI [2.01-7.34]), patients with HCV 
      clearance (OR = 3.17, 95% CI [1.49-6.73]), and CHC patients (OR = 2.21, 95% CI 
      [1.24-3.94]). CONCLUSIONS: HCV infection is a significant risk factor for 
      developing T2DM. CHC, cirrhosis, and decompensated cirrhosis contribute to an 
      increasingly greater risk of T2DM, but HCV clearance spontaneously or through 
      clinical treatment may immediately reduce the risk of the onset and development 
      of T2DM.
FAU - Chen, Ying
AU  - Chen Y
AUID- ORCID: 0000-0001-5359-4808
AD  - Department of Epidemiology and Medical Statistics, School of Public Health, 
      Nantong University, 9 Se-Yuan Road, Nantong, 226019, Jiangsu, China.
FAU - Ji, Hanzhen
AU  - Ji H
AD  - Centre for Liver Diseases, Nantong Third People's Hospital, Nantong University, 
      Nantong, China.
FAU - Shao, Jianguo
AU  - Shao J
AD  - Department of Epidemiology and Medical Statistics, School of Public Health, 
      Nantong University, 9 Se-Yuan Road, Nantong, 226019, Jiangsu, China.
AD  - Centre for Liver Diseases, Nantong Third People's Hospital, Nantong University, 
      Nantong, China.
FAU - Jia, Yulong
AU  - Jia Y
AD  - Department of Epidemiology and Medical Statistics, School of Public Health, 
      Nantong University, 9 Se-Yuan Road, Nantong, 226019, Jiangsu, China.
FAU - Bao, Qi
AU  - Bao Q
AD  - Department of Epidemiology and Medical Statistics, School of Public Health, 
      Nantong University, 9 Se-Yuan Road, Nantong, 226019, Jiangsu, China.
FAU - Zhu, Jianan
AU  - Zhu J
AD  - Department of Epidemiology and Medical Statistics, School of Public Health, 
      Nantong University, 9 Se-Yuan Road, Nantong, 226019, Jiangsu, China.
FAU - Zhang, Lei
AU  - Zhang L
AD  - Research Centre for Public Health, School of Medicine, Tsinghua University, 
      Beijing, China.
AD  - Melbourne Sexual Health Centre, Alfred Health, Melbourne, VIC, Australia.
AD  - Central Clinical School, Faculty of Medicine, Nursing and Health Science, Monash 
      University, Melbourne, Australia.
AD  - School of Public Health and Preventive Medicine, Faculty of Medicine, Nursing and 
      Health Sciences, Monash University, Melbourne, VIC, Australia.
FAU - Shen, Yi
AU  - Shen Y
AUID- ORCID: 0000-0002-5311-9756
AD  - Department of Epidemiology and Medical Statistics, School of Public Health, 
      Nantong University, 9 Se-Yuan Road, Nantong, 226019, Jiangsu, China. 
      sunny@ntu.edu.cn.
LA  - eng
GR  - KYCX19_2084/Graduate Research and Innovation Projects of Jiangsu 
      Province/International
GR  - 2019152/Undergraduate Training Programs for Innovation and Entrepreneurship of 
      Nantong University/International
PT  - Journal Article
PT  - Meta-Analysis
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20191123
PL  - United States
TA  - Dig Dis Sci
JT  - Digestive diseases and sciences
JID - 7902782
RN  - 0 (Hepatitis C Antibodies)
SB  - IM
MH  - Acute Disease
MH  - Case-Control Studies
MH  - Diabetes Mellitus, Type 2/*epidemiology
MH  - End Stage Liver Disease/epidemiology
MH  - Hepatitis C/*epidemiology/immunology
MH  - Hepatitis C Antibodies/immunology
MH  - Hepatitis C, Chronic/drug therapy/*epidemiology
MH  - Humans
MH  - Liver Cirrhosis/*epidemiology
MH  - Network Meta-Analysis
MH  - Odds Ratio
MH  - Remission, Spontaneous
MH  - Risk Factors
MH  - Severity of Illness Index
OTO - NOTNLM
OT  - Hepatitis C virus
OT  - Network meta-analysis
OT  - Observational study
OT  - Type 2 diabetes mellitus
EDAT- 2019/11/24 06:00
MHDA- 2020/11/11 06:00
CRDT- 2019/11/24 06:00
PHST- 2019/08/02 00:00 [received]
PHST- 2019/10/22 00:00 [accepted]
PHST- 2019/11/24 06:00 [pubmed]
PHST- 2020/11/11 06:00 [medline]
PHST- 2019/11/24 06:00 [entrez]
AID - 10.1007/s10620-019-05918-7 [pii]
AID - 10.1007/s10620-019-05918-7 [doi]
PST - ppublish
SO  - Dig Dis Sci. 2020 Jul;65(7):1940-1950. doi: 10.1007/s10620-019-05918-7. Epub 2019 
      Nov 23.