PMID- 31758711
OWN - NLM
STAT- MEDLINE
DCOM- 20211029
LR  - 20211029
IS  - 1365-2826 (Electronic)
IS  - 0953-8194 (Linking)
VI  - 32
IP  - 12
DP  - 2020 Dec
TI  - Nucleus accumbens volume is related to obesity measures in an age-dependent 
      fashion.
PG  - e12812
LID - 10.1111/jne.12812 [doi]
AB  - Motivation theories of obesity suggest that one of the brain mechanisms 
      underlying pathological eating and weight gain is the dysregulation of 
      dopaminergic circuits. Although these dysregulations likely occur at the 
      microscopic level, studies on grey matter volume report macroscopic differences 
      associated with obesity. One region suggested to play a key role in the 
      pathophysiology of obesity is the nucleus accumbens (NAcc). We performed a 
      meta-analysis of findings regarding NAcc volume and overweight/obesity. We 
      additionally examined whether grey matter volume in the NAcc and other mesolimbic 
      areas depends on the longitudinal trajectory of obesity, using the UK Biobank 
      dataset. To this end, we analysed the data using a latent growth model, which 
      identifies whether a certain variable of interest (eg, NAcc volume) is related to 
      another variable's (body mass index [BMI]) initial values or longitudinal 
      trajectories. Our meta-analysis showed that, overall, NAcc volume is positively 
      related to BMI. However, further analyses revealed that the relationship between 
      NAcc volume and BMI is dependent on age. For younger individuals, such a 
      relationship is positive, whereas, for older adults, it is negative. This was 
      corroborated by our analysis in the UK Biobank dataset, which includes older 
      adults, where we found that a higher BMI was associated with a lower NAcc and 
      thalamus volume. Overall, the present study suggests that increased NAcc volume 
      at a young age might be a vulnerability factor for obesity, whereas, at an older 
      age, decreased NAcc volume with increased BMI might be an effect of prolonged 
      influences of neuroinflammation on the brain.
CI  - (c) 2019 British Society for Neuroendocrinology.
FAU - Garcia-Garcia, Isabel
AU  - Garcia-Garcia I
AUID- ORCID: 0000-0002-5873-2664
AD  - Montreal Neurological Institute, McGill University, Montreal, Quebec, Canada.
FAU - Morys, Filip
AU  - Morys F
AUID- ORCID: 0000-0001-8996-2676
AD  - Montreal Neurological Institute, McGill University, Montreal, Quebec, Canada.
FAU - Dagher, Alain
AU  - Dagher A
AUID- ORCID: 0000-0002-0945-5779
AD  - Montreal Neurological Institute, McGill University, Montreal, Quebec, Canada.
LA  - eng
GR  - MC_PC_17228/MRC_/Medical Research Council/United Kingdom
GR  - MC_QA137853/MRC_/Medical Research Council/United Kingdom
GR  - CIHR/Canada
PT  - Journal Article
PT  - Meta-Analysis
PT  - Research Support, Non-U.S. Gov't
DEP - 20191211
PL  - United States
TA  - J Neuroendocrinol
JT  - Journal of neuroendocrinology
JID - 8913461
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Aging/*pathology
MH  - Body Mass Index
MH  - Databases, Factual
MH  - Female
MH  - Gray Matter/diagnostic imaging
MH  - Humans
MH  - Limbic System/pathology
MH  - Magnetic Resonance Imaging
MH  - Male
MH  - Middle Aged
MH  - Motivation
MH  - Nucleus Accumbens/*diagnostic imaging
MH  - Obesity/*diagnostic imaging
MH  - Thalamus/pathology
MH  - Ventral Striatum/diagnostic imaging
MH  - Young Adult
OTO - NOTNLM
OT  - adiposity
OT  - age
OT  - grey matter volume
OT  - ventral striatum
EDAT- 2019/11/24 06:00
MHDA- 2021/10/30 06:00
CRDT- 2019/11/24 06:00
PHST- 2019/09/17 00:00 [received]
PHST- 2019/11/05 00:00 [revised]
PHST- 2019/11/20 00:00 [accepted]
PHST- 2019/11/24 06:00 [pubmed]
PHST- 2021/10/30 06:00 [medline]
PHST- 2019/11/24 06:00 [entrez]
AID - 10.1111/jne.12812 [doi]
PST - ppublish
SO  - J Neuroendocrinol. 2020 Dec;32(12):e12812. doi: 10.1111/jne.12812. Epub 2019 Dec 
      11.