PMID- 31759430
OWN - NLM
STAT- MEDLINE
DCOM- 20200427
LR  - 20200427
IS  - 1937-6448 (Print)
IS  - 1937-6448 (Linking)
VI  - 349
DP  - 2019
TI  - The impact of endoplasmic reticulum stress responses in dendritic cell 
      immunobiology.
PG  - 153-176
LID - S1937-6448(19)30075-9 [pii]
LID - 10.1016/bs.ircmb.2019.08.004 [doi]
AB  - Dendritic cells (DCs) are critical for bridging innate and adaptive immunity. 
      They do so by presenting antigens to T cells, and by expressing diverse molecules 
      that further promote T cell activation, differentiation and memory formation. 
      During this process, intracellular and extracellular factors can perturb the 
      protein-folding capacity of endoplasmic reticulum (ER) and induce a cellular 
      state of "ER stress," which is controlled and resolved by the unfolded protein 
      response (UPR). Interestingly, various studies have shown that DCs can activate 
      UPR-related pathways even in the absence of global ER stress, and that this 
      process can modulate their normal activity. In other settings, such as cancer, 
      adverse microenvironmental conditions have been demonstrated to evoke severe ER 
      stress and persistent activation of the UPR in tumor-infiltrating DCs. This 
      process disrupts their metabolism and local antigen-presenting capacity, hence 
      impeding the initiation and maintenance of anti-cancer immunity. Here, we review 
      recent findings on how canonical and non-canonical UPR activation impacts DC 
      immunobiology at the steady-state, upon activation via pattern recognition 
      receptors, and under diverse pathological conditions. We also discuss the 
      potential therapeutic implications that targeting the UPR in DCs may have in the 
      context of cancer and in other pathologies such as graft-versus-host disease.
CI  - (c) 2019 Elsevier Inc. All rights reserved.
FAU - Salvagno, Camilla
AU  - Salvagno C
AD  - Department of Obstetrics and Gynecology, Weill Cornell Medicine, New York, NY, 
      United States; Sandra and Edward Meyer Cancer Center, Weill Cornell Medicine, New 
      York, NY, United States.
FAU - Cubillos-Ruiz, Juan R
AU  - Cubillos-Ruiz JR
AD  - Department of Obstetrics and Gynecology, Weill Cornell Medicine, New York, NY, 
      United States; Sandra and Edward Meyer Cancer Center, Weill Cornell Medicine, New 
      York, NY, United States; Weill Cornell Graduate School of Medical Sciences, 
      Cornell University, New York, NY, United States. Electronic address: 
      jur2016@med.cornell.edu.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PT  - Review
DEP - 20190911
PL  - Netherlands
TA  - Int Rev Cell Mol Biol
JT  - International review of cell and molecular biology
JID - 101475846
SB  - IM
MH  - Animals
MH  - Dendritic Cells/*immunology/pathology
MH  - Endoplasmic Reticulum Stress/*immunology
MH  - Humans
MH  - Unfolded Protein Response
OTO - NOTNLM
OT  - Dendritic cells
OT  - ER stress
OT  - IRE1
OT  - Immunobiology
OT  - PERK
OT  - Unfolded protein response
OT  - XBP1
EDAT- 2019/11/25 06:00
MHDA- 2020/04/28 06:00
CRDT- 2019/11/25 06:00
PHST- 2019/11/25 06:00 [entrez]
PHST- 2019/11/25 06:00 [pubmed]
PHST- 2020/04/28 06:00 [medline]
AID - S1937-6448(19)30075-9 [pii]
AID - 10.1016/bs.ircmb.2019.08.004 [doi]
PST - ppublish
SO  - Int Rev Cell Mol Biol. 2019;349:153-176. doi: 10.1016/bs.ircmb.2019.08.004. Epub 
      2019 Sep 11.