PMID- 31759787
OWN - NLM
STAT- MEDLINE
DCOM- 20200723
LR  - 20200723
IS  - 1916-7075 (Electronic)
IS  - 0828-282X (Linking)
VI  - 36
IP  - 1
DP  - 2020 Jan
TI  - Sex Differences in New York Heart Association Functional Classification and 
      Survival in Acute Heart Failure Patients With Preserved or Reduced Ejection 
      Fraction.
PG  - 30-36
LID - S0828-282X(19)31167-5 [pii]
LID - 10.1016/j.cjca.2019.08.020 [doi]
AB  - BACKGROUND: The aim of this study was to evaluate the influence of sex on the 
      relationship between the New York Heart Association (NYHA) functional 
      classification and survival in acute decompensated heart failure (HF) patients 
      with preserved or reduced ejection fraction (EF). METHODS: Of 4842 patients 
      enrolled in the Acute Decompensated Heart Failure Syndromes (ATTEND) registry, 
      4717 (2730 men and 1987 women) were investigated to assess the association of 
      sex, NYHA functional class, and preserved or reduced EF with all-cause death. Men 
      and women were divided into 6 groups based on left ventricular EF (preserved or 
      reduced) and NYHA functional class (II, III, or IV) at admission. RESULTS: Among 
      both sexes with preserved EF, multivariable analysis confirmed that NYHA 
      functional class IV was associated with a significantly higher risk of all-cause 
      death than NYHA functional class II. Similarly, in women with reduced EF, NYHA 
      functional class IV was a significant predictor of all-cause death compared with 
      class II. However, in men with reduced EF, the adjusted risk of all-cause death 
      was similar for those in NYHA functional classes II, III, and IV. Furthermore, 
      the interaction between sex and NYHA functional classes II to IV was 
      statistically significant for all-cause death in reduced EF patients (P for 
      interaction = 0.037), but not in preserved EF patients (P for interaction = 
      0.711). CONCLUSIONS: NYHA functional class IV was a significant predictor of 
      all-cause death in both sexes with preserved EF, whereas NYHA functional class IV 
      was a significant predictor of all-cause death in women, but not in men, with 
      reduced EF.
CI  - Copyright (c) 2019 Canadian Cardiovascular Society. Published by Elsevier Inc. All 
      rights reserved.
FAU - Kajimoto, Katsuya
AU  - Kajimoto K
AD  - Division of Cardiology, Sekikawa Hospital, Tokyo, Japan. Electronic address: 
      kkajimoto@gmail.com.
FAU - Sato, Naoki
AU  - Sato N
AD  - Department of Cardiovascular Medicine, Kawaguchi Cardiovascular and Respiratory 
      Hospital, Saitama, Japan.
CN  - Investigators of the Acute Decompensated Heart Failure Syndromes (ATTEND) 
      Registry
LA  - eng
PT  - Journal Article
DEP - 20190821
PL  - England
TA  - Can J Cardiol
JT  - The Canadian journal of cardiology
JID - 8510280
SB  - IM
CIN - Can J Cardiol. 2020 Jan;36(1):4-6. PMID: 31787435
MH  - Acute Disease
MH  - *Cardiology
MH  - Female
MH  - Global Health
MH  - Heart Failure/*classification/epidemiology/physiopathology
MH  - Humans
MH  - Incidence
MH  - Male
MH  - New York
MH  - *Registries
MH  - Sex Factors
MH  - *Societies, Medical
MH  - Stroke Volume/*physiology
MH  - Survival Rate/trends
EDAT- 2019/11/25 06:00
MHDA- 2020/07/24 06:00
CRDT- 2019/11/25 06:00
PHST- 2019/04/19 00:00 [received]
PHST- 2019/08/16 00:00 [revised]
PHST- 2019/08/16 00:00 [accepted]
PHST- 2019/11/25 06:00 [pubmed]
PHST- 2020/07/24 06:00 [medline]
PHST- 2019/11/25 06:00 [entrez]
AID - S0828-282X(19)31167-5 [pii]
AID - 10.1016/j.cjca.2019.08.020 [doi]
PST - ppublish
SO  - Can J Cardiol. 2020 Jan;36(1):30-36. doi: 10.1016/j.cjca.2019.08.020. Epub 2019 
      Aug 21.