PMID- 31760385
OWN - NLM
STAT- MEDLINE
DCOM- 20200929
LR  - 20200929
IS  - 1945-4589 (Electronic)
IS  - 1945-4589 (Linking)
VI  - 11
IP  - 22
DP  - 2019 Nov 23
TI  - Abnormal gut microbiota composition contributes to the development of type 2 
      diabetes mellitus in db/db mice.
PG  - 10454-10467
LID - 10.18632/aging.102469 [doi]
AB  - It is well recognized that type 2 diabetes mellitus (T2DM) is an age-related 
      metabolic disease, emerging gradually as a major global health burden that has 
      gained public attention. Meanwhile, increasing attention is paid to the crucial 
      role of gut microbiota in the pathogenesis and therapeutic mechanisms of 
      metabolic disorders, especially T2DM. In this study, we used C57 BL/KS db/db male 
      mice as a T2DM murine model. We found that the beta-diversity and relative 
      abundances of gut bacteria were obviously altered in db/db mice, associated with 
      a significant increase in Verrucomicrobia at six levels (phylum, class, order, 
      etc.) and family S24-7 and a significant decrease in Bacteroidaceae at family, 
      genus, and species levels, as well as Prevotellaceae at family and genus levels. 
      Furthermore, fecal bacteria from db/db and m/m mice transplanted into 
      pseudo-germ-free mice showed a significant change in the metabolic parameters, 
      including the body weight, fasting blood glucose, fluid and food intake, and 
      alterations in the composition of the gut microbiota. Taken together, these 
      findings suggest that abnormalities in the composition of the gut microbiota 
      might contribute to the development of T2DM and that potential therapeutic 
      strategies improving gut microbiota might provide beneficial effects for 
      individuals with T2DM and age-related glucose intolerance.
FAU - Yu, Fan
AU  - Yu F
AD  - Department of Endocrinology, The Third Affiliated Hospital of Soochow University, 
      Changzhou, China.
FAU - Han, Wei
AU  - Han W
AD  - Department of Neurosurgery, The Third Affiliated Hospital of Soochow University, 
      Changzhou, China.
FAU - Zhan, Gaofeng
AU  - Zhan G
AD  - Department of Anesthesiology, Tongji Hospital, Tongji Medical College, Huazhong 
      University of Science and Technology, Wuhan, China.
FAU - Li, Shan
AU  - Li S
AD  - Department of Anesthesiology, Tongji Hospital, Tongji Medical College, Huazhong 
      University of Science and Technology, Wuhan, China.
FAU - Jiang, Xiaohong
AU  - Jiang X
AD  - Department of Endocrinology, The Third Affiliated Hospital of Soochow University, 
      Changzhou, China.
FAU - Wang, Long
AU  - Wang L
AD  - Department of Endocrinology, The Third Affiliated Hospital of Soochow University, 
      Changzhou, China.
FAU - Xiang, Shoukui
AU  - Xiang S
AD  - Department of Endocrinology, The Third Affiliated Hospital of Soochow University, 
      Changzhou, China.
FAU - Zhu, Bin
AU  - Zhu B
AD  - Department of Critical Care Medicine, The Third Affiliated Hospital of Soochow 
      University, Changzhou, China.
FAU - Yang, Ling
AU  - Yang L
AD  - Department of Cardiology, The Third Affiliated Hospital of Soochow University, 
      Changzhou, China.
FAU - Luo, Ailin
AU  - Luo A
AD  - Department of Anesthesiology, Tongji Hospital, Tongji Medical College, Huazhong 
      University of Science and Technology, Wuhan, China.
FAU - Hua, Fei
AU  - Hua F
AD  - Department of Endocrinology, The Third Affiliated Hospital of Soochow University, 
      Changzhou, China.
FAU - Yang, Chun
AU  - Yang C
AD  - Department of Anesthesiology, Tongji Hospital, Tongji Medical College, Huazhong 
      University of Science and Technology, Wuhan, China.
AD  - Department of Anesthesiology and Perioperative Medicine, The First Affiliated 
      Hospital of Nanjing Medical University, Nanjing, China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20191123
PL  - United States
TA  - Aging (Albany NY)
JT  - Aging
JID - 101508617
SB  - IM
MH  - Animals
MH  - Diabetes Mellitus, Type 2/*microbiology
MH  - Fecal Microbiota Transplantation
MH  - Gastrointestinal Microbiome/*physiology
MH  - Male
MH  - Mice
MH  - Mice, Inbred C57BL
PMC - PMC6914402
OTO - NOTNLM
OT  - diabetes mellitus
OT  - gut microbiota
OT  - pseudo-germ-free mice
COIS- CONFLICTS OF INTEREST: All of the authors declare that they have no potential 
      conflicts of interest to disclose.
EDAT- 2019/11/25 06:00
MHDA- 2020/09/30 06:00
PMCR- 2019/11/30
CRDT- 2019/11/25 06:00
PHST- 2019/07/25 00:00 [received]
PHST- 2019/11/08 00:00 [accepted]
PHST- 2019/11/25 06:00 [pubmed]
PHST- 2020/09/30 06:00 [medline]
PHST- 2019/11/25 06:00 [entrez]
PHST- 2019/11/30 00:00 [pmc-release]
AID - 102469 [pii]
AID - 10.18632/aging.102469 [doi]
PST - ppublish
SO  - Aging (Albany NY). 2019 Nov 23;11(22):10454-10467. doi: 10.18632/aging.102469. 
      Epub 2019 Nov 23.