PMID- 31762123
OWN - NLM
STAT- MEDLINE
DCOM- 20200601
LR  - 20200601
IS  - 1439-0388 (Electronic)
IS  - 0931-2668 (Linking)
VI  - 137
IP  - 1
DP  - 2020 Jan
TI  - Investigating the relationship between vaginal microbiota and host genetics and 
      their impact on immune response and farrowing traits in commercial gilts.
PG  - 84-102
LID - 10.1111/jbg.12456 [doi]
AB  - Our objectives were to evaluate the interaction between host genetics and vaginal 
      microbiota and their relationships with antibody (Ab) response to porcine 
      reproductive and respiratory syndrome virus (PRRSV) vaccination and farrowing 
      performance in commercial gilts. The farrowing performance traits were number 
      born alive, number weaning (NW), total number born, number born dead, stillborn, 
      mummies and preweaning mortality (PWM). The vaginal microbiota was collected on 
      days 4 (D4) and 52 (D52) after vaccination for PRRSV. Blood samples were 
      collected on D52 for Ab measurement. Actinobacteria, Bacterioidetes, Firmicutes, 
      Proteobacteria and Tenericutes were the most abundant Phyla identified in the 
      vaginal microbiota. Heritability ranged from ~0 to 0.60 (Fusobacterium) on D4 and 
      from ~0 to 0.63 (Terrisporobacter) on D52, with 43 operational taxonomic units 
      (OTUs) presenting moderate to high heritability. One major QTL on chromosome 12 
      was identified for 5 OTUs (Clostridiales, Acinetobacter, Ruminococcaceae, 
      Campylobacter and Anaerococcus), among other 19 QTL. The microbiability for Ab 
      response to PRRSV vaccination was low for both days (<0.07). For farrowing 
      performance, microbiability varied from <0.001 to 0.15 (NW on D4). For NW and 
      PWM, the microbiability was greater than the heritability estimates. 
      Actinobacillus, Streptococcus, Campylobacter, Anaerococcus, Mollicutes, 
      Peptostreptococcus, Treponema and Fusobacterium showed different abundance 
      between low and high Ab responders. Finally, canonical discriminant analyses 
      revealed that vaginal microbiota was able to classify gilts in high and low Ab 
      responders to PRRSV vaccination with a misclassification rate of <0.02. Although 
      the microbiota explained limited variation in Ab response and farrowing 
      performance traits, there is still potential to explore the use of vaginal 
      microbiota to explain variation in traits such as NW and PWM. In addition, these 
      results revealed that there is a partial control of host genetic over vaginal 
      microbiota, suggesting a possibility for genetic selection on the vaginal 
      microbiota.
CI  - (c) 2019 Blackwell Verlag GmbH.
FAU - Sanglard, Leticia P
AU  - Sanglard LP
AD  - Department of Animal Science, Iowa State University, Ames, Iowa.
FAU - Schmitz-Esser, Stephan
AU  - Schmitz-Esser S
AD  - Department of Animal Science, Iowa State University, Ames, Iowa.
AD  - Interdepartmental Microbiology Graduate Program, Iowa State University, Ames, 
      Iowa.
FAU - Gray, Kent A
AU  - Gray KA
AD  - Smithfield Premium Genetic, Rose Hill, North Carolina.
FAU - Linhares, Daniel C L
AU  - Linhares DCL
AD  - Department of Veterinary Diagnostic & Production Animal Medicine, Iowa State 
      University, Ames, Iowa.
FAU - Yeoman, Carl J
AU  - Yeoman CJ
AD  - Department of Animal & Range Sciences, Montana State University, Bozeman, 
      Montana.
FAU - Dekkers, Jack C M
AU  - Dekkers JCM
AD  - Department of Animal Science, Iowa State University, Ames, Iowa.
FAU - Niederwerder, Megan C
AU  - Niederwerder MC
AD  - Department of Diagnostic Medicine/Pathobiology, Kansas State University, 
      Manhattan, Kansas.
FAU - Serao, Nick V L
AU  - Serao NVL
AUID- ORCID: 0000-0002-6758-208X
AD  - Department of Animal Science, Iowa State University, Ames, Iowa.
LA  - eng
GR  - Iowa Pork Producers Association/
GR  - USDA-NRSP-8 Swine Genome Coordination Effort/
GR  - Smithfield Premium Genetics/
PT  - Journal Article
DEP - 20191125
PL  - Germany
TA  - J Anim Breed Genet
JT  - Journal of animal breeding and genetics = Zeitschrift fur Tierzuchtung und 
      Zuchtungsbiologie
JID - 100955807
SB  - IM
MH  - Animals
MH  - Female
MH  - Genome-Wide Association Study
MH  - Genotype
MH  - Host-Pathogen Interactions/*genetics/*immunology
MH  - *Microbiota/immunology
MH  - Phenotype
MH  - Sus scrofa/*genetics/*immunology/microbiology/virology
MH  - Vaccination
MH  - Vagina/*microbiology
OTO - NOTNLM
OT  - GWAS
OT  - farrowing performance
OT  - heritability
OT  - microbiota
OT  - porcine reproductive and respiratory syndrome
EDAT- 2019/11/26 06:00
MHDA- 2020/06/02 06:00
CRDT- 2019/11/26 06:00
PHST- 2019/06/18 00:00 [received]
PHST- 2019/09/30 00:00 [revised]
PHST- 2019/10/22 00:00 [accepted]
PHST- 2019/11/26 06:00 [pubmed]
PHST- 2020/06/02 06:00 [medline]
PHST- 2019/11/26 06:00 [entrez]
AID - 10.1111/jbg.12456 [doi]
PST - ppublish
SO  - J Anim Breed Genet. 2020 Jan;137(1):84-102. doi: 10.1111/jbg.12456. Epub 2019 Nov 
      25.