PMID- 31762875
OWN - NLM
STAT- MEDLINE
DCOM- 20191225
LR  - 20220411
IS  - 1937-8688 (Electronic)
VI  - 34
DP  - 2019
TI  - Modifiable predictors of severe heart failure in Morocco: a descriptive study 
      using routinely collected health data.
PG  - 6
LID - 10.11604/pamj.2019.34.6.17998 [doi]
LID - 6
AB  - INTRODUCTION: Heart Failure (HF) is a growing public health concern in Morocco 
      and there is a striking paucity on determinants of severe HF (SHF) in this 
      population. The aim of this study was to identify patients admitted with HF at 
      Ibn Rochd Hospital, Casablanca from 2011 onwards, when electronic record keeping 
      began. METHODS: A total of 105 patients underwent a series of cardiological 
      examinations between July 2011 and January 2014. The New York Heart Association 
      (NYHA) criteria was used to evaluate the severity of HF. Patients with NYHA 
      classification gradings of I and II were defined as having moderate HF (MHF) and 
      those graded as III and IV were defined as having a SHF. Univariable and 
      multivariable risk factors associated with SHF were explored using logistic 
      regression. The results were reported following the RECORD (Reporting of studies 
      Conducted using Observational Routinely-collected Data) statement. RESULTS: A 
      total of 24 (33%) patients were identified as having a SHF. Four predictors of 
      SHF were identified in univariate analysis: haemoglobin <12g/dL, 
      neutrophil-to-lymphocyte ratio (NLR) >3, mean corpuscular haemoglobin 
      concentration (MCHC) <32 picolitre, and high density lipoprotein (HDL) <0.35 
      (mmol/L). Only NLR>3 and HDL <0.35 mmol/L remained independent predictors in 
      multivariable analysis. Patients with NLR >3 were at 6-fold increased odds of SHF 
      [adjusted odds ratio (AOR): 6.78, 95% confidence interval (CI): 1.40-32.80, 
      p=0.017], and those with HDL<0.35 (mmol/L) were at 10-fold increased odds of SHF 
      [AOR: 10.11, 95% CI: 2.26-45.27, p=0.002]. CONCLUSION: The independent biomarkers 
      of SHF identified in this study provide valuable information to ward clinicians 
      in resource-constrained facilities to identify patients vulnerable to developing 
      severe heart complications.
CI  - (c) Alpha Kone et al.
FAU - Kone, Alpha
AU  - Kone A
AD  - Department of Cardiology, Ibn Rochd Hospital, Faculty of Medicine and Pharmacy, 
      Hassan II University of Casablanca, Morocco.
AD  - Faculty of Medicine Pharmacy and Odontostomatology, Gamal Abdel Nasser University 
      of Conakry, Conakry, Guinea.
FAU - Cherif, Mahamoud Sama
AU  - Cherif MS
AD  - Faculty of Medicine Pharmacy and Odontostomatology, Gamal Abdel Nasser University 
      of Conakry, Conakry, Guinea.
AD  - Infectious Diseases Data Observatory, Centre for Tropical Medicine & Global 
      Health, Nuffield Department of Clinical Medicine, University of Oxford, Oxford, 
      UK.
FAU - Prabin, Dahal
AU  - Prabin D
AD  - Infectious Diseases Data Observatory, Centre for Tropical Medicine & Global 
      Health, Nuffield Department of Clinical Medicine, University of Oxford, Oxford, 
      UK.
FAU - Dumre, Shyam Prakash
AU  - Dumre SP
AD  - Institute of Tropical Medicine (NEKKEN), Nagasaki University, Nagasaki, Japan.
FAU - Doumbouya, Almamy Ibrahim
AU  - Doumbouya AI
AD  - Department of Cardiology, Ibn Rochd Hospital, Faculty of Medicine and Pharmacy, 
      Hassan II University of Casablanca, Morocco.
FAU - Kapche, Diane Fotso
AU  - Kapche DF
AD  - Department of Cardiology, Ibn Rochd Hospital, Faculty of Medicine and Pharmacy, 
      Hassan II University of Casablanca, Morocco.
FAU - Camara, Facely
AU  - Camara F
AD  - Faculty of Medicine Pharmacy and Odontostomatology, Gamal Abdel Nasser University 
      of Conakry, Conakry, Guinea.
FAU - Saousan, Serbout
AU  - Saousan S
AD  - Department of Cardiology, Ibn Rochd Hospital, Faculty of Medicine and Pharmacy, 
      Hassan II University of Casablanca, Morocco.
FAU - Sara, Khaddi
AU  - Sara K
AD  - Department of Cardiology, Ibn Rochd Hospital, Faculty of Medicine and Pharmacy, 
      Hassan II University of Casablanca, Morocco.
FAU - Diakite, Mandiou
AU  - Diakite M
AD  - Faculty of Medicine Pharmacy and Odontostomatology, Gamal Abdel Nasser University 
      of Conakry, Conakry, Guinea.
FAU - Cisse, Mohamed
AU  - Cisse M
AD  - Faculty of Medicine Pharmacy and Odontostomatology, Gamal Abdel Nasser University 
      of Conakry, Conakry, Guinea.
FAU - Azzouzi, Leila
AU  - Azzouzi L
AD  - Department of Cardiology, Ibn Rochd Hospital, Faculty of Medicine and Pharmacy, 
      Hassan II University of Casablanca, Morocco.
FAU - Habbal, Rachida
AU  - Habbal R
AD  - Department of Cardiology, Ibn Rochd Hospital, Faculty of Medicine and Pharmacy, 
      Hassan II University of Casablanca, Morocco.
LA  - eng
PT  - Journal Article
DEP - 20190903
PL  - Uganda
TA  - Pan Afr Med J
JT  - The Pan African medical journal
JID - 101517926
RN  - 0 (Biomarkers)
RN  - 0 (Hemoglobins)
SB  - IM
MH  - Aged
MH  - Biomarkers/metabolism
MH  - Electronic Health Records
MH  - Female
MH  - Heart Failure/*epidemiology/physiopathology
MH  - Hemoglobins/*metabolism
MH  - Hospitalization
MH  - Humans
MH  - Lymphocytes/*metabolism
MH  - Male
MH  - Middle Aged
MH  - Morocco
MH  - Neutrophils/*metabolism
MH  - Risk Factors
MH  - Severity of Illness Index
PMC - PMC6850741
OTO - NOTNLM
OT  - Heart failure
OT  - Morocco
OT  - hdl
OT  - neutrophils-lymphocytes-ratio
COIS- The authors declare no competing interests.
EDAT- 2019/11/26 06:00
MHDA- 2019/12/26 06:00
PMCR- 2019/09/03
CRDT- 2019/11/26 06:00
PHST- 2018/12/21 00:00 [received]
PHST- 2019/06/03 00:00 [accepted]
PHST- 2019/11/26 06:00 [entrez]
PHST- 2019/11/26 06:00 [pubmed]
PHST- 2019/12/26 06:00 [medline]
PHST- 2019/09/03 00:00 [pmc-release]
AID - PAMJ-34-6 [pii]
AID - 10.11604/pamj.2019.34.6.17998 [doi]
PST - epublish
SO  - Pan Afr Med J. 2019 Sep 3;34:6. doi: 10.11604/pamj.2019.34.6.17998. eCollection 
      2019.