PMID- 31763142
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20231019
IS  - 2198-3844 (Print)
IS  - 2198-3844 (Electronic)
IS  - 2198-3844 (Linking)
VI  - 6
IP  - 22
DP  - 2019 Nov
TI  - Noncovalent Targeting of Nanocarriers to Immune Cells with Polyphosphoester-Based 
      Surfactants in Human Blood Plasma.
PG  - 1901199
LID - 10.1002/advs.201901199 [doi]
LID - 1901199
AB  - Dendritic cells (DCs) are part of the immune system and can internalize pathogens 
      by carbohydrate receptors. The uptake induces maturation and migration of the DCs 
      resulting in an adaptive immune response by presenting antigens to T-cells. Thus, 
      targeted delivery to DCs is a powerful tool for immunotherapy. However, in blood, 
      specific targeting is challenging as blood proteins adsorb to the nanocarriers 
      and mask the targeting molecules. Additionally, covalent coupling of targeting 
      groups to nanocarriers requires new chemistry for each nanocarrier, while a 
      general strategy is missing. A general protocol by noncovalent adsorption of 
      mannosylated polyphosphoesters (PPEs) on the nanocarriers' surface resulting in 
      specific uptake into DCs combined with low protein adsorption of PPEs is 
      presented. PPEs with hydrophobic anchors and multiple mannose units are reported 
      and adsorbed to different model nanocarriers. Their protein corona remain similar 
      to pure stealth nanocarriers and prove only low uptake into nontargeted cells 
      (monocytes). Due to the "stealth" properties of PPEs, a high specific uptake into 
      DCs is achieved after incubation in human blood plasma, proving an efficient 
      combination of "stealth" and targeting after simple adsorption of the PPEs. This 
      strategy can transform any nanocarrier into DC-targeting by noncovalent 
      adsorption of PPEs and will aid in developing novel immunotherapies.
CI  - (c) 2019 The Authors. Published by WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
FAU - Simon, Johanna
AU  - Simon J
AD  - Max-Planck-Institut fur Polymerforschung Ackermannweg 10 55128 Mainz Germany.
AD  - Dermatology Clinic University Medical Center of the Johannes Gutenberg-University 
      Mainz Langenbeckstr. 1 55131 Mainz Germany.
FAU - Bauer, Kristin N
AU  - Bauer KN
AD  - Max-Planck-Institut fur Polymerforschung Ackermannweg 10 55128 Mainz Germany.
FAU - Langhanki, Jens
AU  - Langhanki J
AD  - Institute of Organic Chemistry Johannes Gutenberg-University Mainz Duesbergweg 
      10-14 55128 Mainz Germany.
FAU - Opatz, Till
AU  - Opatz T
AD  - Institute of Organic Chemistry Johannes Gutenberg-University Mainz Duesbergweg 
      10-14 55128 Mainz Germany.
FAU - Mailander, Volker
AU  - Mailander V
AD  - Max-Planck-Institut fur Polymerforschung Ackermannweg 10 55128 Mainz Germany.
AD  - Dermatology Clinic University Medical Center of the Johannes Gutenberg-University 
      Mainz Langenbeckstr. 1 55131 Mainz Germany.
FAU - Landfester, Katharina
AU  - Landfester K
AD  - Max-Planck-Institut fur Polymerforschung Ackermannweg 10 55128 Mainz Germany.
FAU - Wurm, Frederik R
AU  - Wurm FR
AUID- ORCID: 0000-0002-6955-8489
AD  - Max-Planck-Institut fur Polymerforschung Ackermannweg 10 55128 Mainz Germany.
LA  - eng
PT  - Journal Article
DEP - 20191004
PL  - Germany
TA  - Adv Sci (Weinh)
JT  - Advanced science (Weinheim, Baden-Wurttemberg, Germany)
JID - 101664569
PMC - PMC6864500
OTO - NOTNLM
OT  - dendritic cells
OT  - protein corona
OT  - ring-opening polymerization
OT  - stealth effect
OT  - targeted drug delivery
COIS- The authors declare no conflict of interest.
EDAT- 2019/11/26 06:00
MHDA- 2019/11/26 06:01
PMCR- 2019/10/04
CRDT- 2019/11/26 06:00
PHST- 2019/05/20 00:00 [received]
PHST- 2019/08/05 00:00 [revised]
PHST- 2019/11/26 06:00 [entrez]
PHST- 2019/11/26 06:00 [pubmed]
PHST- 2019/11/26 06:01 [medline]
PHST- 2019/10/04 00:00 [pmc-release]
AID - ADVS1363 [pii]
AID - 10.1002/advs.201901199 [doi]
PST - epublish
SO  - Adv Sci (Weinh). 2019 Oct 4;6(22):1901199. doi: 10.1002/advs.201901199. 
      eCollection 2019 Nov.