PMID- 31764620
OWN - NLM
STAT- MEDLINE
DCOM- 20210514
LR  - 20210514
IS  - 1540-0514 (Electronic)
IS  - 1073-2322 (Linking)
VI  - 54
IP  - 1
DP  - 2020 Jul
TI  - Tenascin C Plasma Levels in Critically Ill Patients with or Without Sepsis: A 
      Multicenter Observational Study.
PG  - 62-69
LID - 10.1097/SHK.0000000000001481 [doi]
AB  - Tenascin C (TNC) is an extracellular matrix protein able to modulate the immune 
      response. Knowledge regarding its role during sepsis and general critical illness 
      is still limited. We here assessed the temporal dynamics of plasma TNC during 
      sepsis and nonseptic critical illness, its capacity to predict patient outcome, 
      and its specificity toward infection. TNC plasma concentrations were measured in 
      895 consecutive sepsis patients on ICU admission, day 2 and 4 thereafter, and, in 
      a subset, before ICU discharge. To assess TNC diagnostic value, we compared 
      patients with abdominal sepsis (N = 143) to noninfectious abdominal surgery 
      controls (N = 98), and patients with severe community-acquired pneumonia (CAP, 
      N = 227) to patients whose CAP diagnosis was retrospectively refuted (no-CAP 
      controls, N = 70). Plasma TNC levels were persistently elevated in sepsis 
      patients compared with healthy volunteers throughout the ICU stay. TNC levels 
      varied by the site of infection and increased with the number of organs failing. 
      Association of TNC levels with 30-day mortality could be wholly attributed to 
      differences in disease severity. Noninfectious ICU patients also showed elevated 
      TNC levels, albeit with different temporal dynamics. Although admission TNC was 
      higher in CAP than in no-CAP patients, it performed poorly in distinguishing the 
      2 groups.TNC plasma levels are persistently elevated during sepsis and nonseptic 
      critical illness. In sepsis patients, they are reflective of disease severity 
      more than independent predictors of mortality. Despite higher levels in patients 
      with infection compared with noninfectious controls, TNC does not perform 
      sufficiently to be used as a standalone biomarker discriminating sepsis from 
      noninfectious critical illness.
FAU - Meijer, Mariska T
AU  - Meijer MT
AD  - Center for Experimental and Molecular Medicine, Amsterdam University Medical 
      Centers, Academic Medical Center, University of Amsterdam.
AD  - Amsterdam Institute for Infection and Immunity, Amsterdam University Medical 
      Centers, Amsterdam.
FAU - Uhel, Fabrice
AU  - Uhel F
AD  - Center for Experimental and Molecular Medicine, Amsterdam University Medical 
      Centers, Academic Medical Center, University of Amsterdam.
AD  - Amsterdam Institute for Infection and Immunity, Amsterdam University Medical 
      Centers, Amsterdam.
FAU - Cremer, Olaf L
AU  - Cremer OL
AD  - Department of Intensive Care Medicine, University Medical Center Utrecht, 
      Utrecht.
FAU - Schultz, Marcus J
AU  - Schultz MJ
AD  - Department of Intensive Care.
FAU - van der Poll, Tom
AU  - van der Poll T
AD  - Center for Experimental and Molecular Medicine, Amsterdam University Medical 
      Centers, Academic Medical Center, University of Amsterdam.
AD  - Amsterdam Institute for Infection and Immunity, Amsterdam University Medical 
      Centers, Amsterdam.
AD  - Division of Infectious Diseases, Amsterdam University Medical Centers, Academic 
      Medical Center, University of Amsterdam, Amsterdam, the Netherlands.
CN  - MARS consortium
LA  - eng
PT  - Clinical Trial
PT  - Journal Article
PT  - Multicenter Study
PT  - Observational Study
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Shock
JT  - Shock (Augusta, Ga.)
JID - 9421564
RN  - 0 (Biomarkers)
RN  - 0 (TNC protein, human)
RN  - 0 (Tenascin)
SB  - IM
MH  - Aged
MH  - Biomarkers/blood
MH  - Case-Control Studies
MH  - *Critical Illness/mortality
MH  - Female
MH  - Humans
MH  - Intensive Care Units/statistics & numerical data
MH  - Male
MH  - Middle Aged
MH  - Sepsis/*blood/mortality
MH  - Severity of Illness Index
MH  - Tenascin/*blood
EDAT- 2019/11/26 06:00
MHDA- 2021/05/15 06:00
CRDT- 2019/11/26 06:00
PHST- 2019/11/26 06:00 [pubmed]
PHST- 2021/05/15 06:00 [medline]
PHST- 2019/11/26 06:00 [entrez]
AID - 00024382-202007000-00011 [pii]
AID - 10.1097/SHK.0000000000001481 [doi]
PST - ppublish
SO  - Shock. 2020 Jul;54(1):62-69. doi: 10.1097/SHK.0000000000001481.