PMID- 31765029
OWN - NLM
STAT- MEDLINE
DCOM- 20210112
LR  - 20230918
IS  - 1525-1470 (Electronic)
IS  - 0736-8046 (Linking)
VI  - 37
IP  - 1
DP  - 2020 Jan
TI  - Isotretinoin-induced sacroiliitis: Case series of four patients and a systematic 
      review of the literature.
PG  - 171-175
LID - 10.1111/pde.14035 [doi]
AB  - Isotretinoin is the mainstay treatment in severe acne; however, its 
      musculoskeletal adverse effects such as lower-back pain can be disabling. Herein, 
      we present four cases of isotretinoin-induced sacroiliitis with variable 
      severity. We also present a review of the literature of isotretinoin-induced 
      sacroiliitis. All our cases were male and human leukocyte antigen (HLA)-B27 
      negative. Sacroiliitis was detected a median of 55 (10-120) days after 
      isotretinoin initiation. Two patients were responsive to baseline sulfasalazine 
      and indomethacin treatment, while the other two patients required more intensive 
      treatments: adalimumab in one and methotrexate in the other. We also identified 
      15 articles describing 33 patients (17 of whom were female) with 
      isotretinoin-induced sacroiliitis. Most of them were responsive to low-to-medium 
      doses of systemic steroids or non-steroidal anti-inflammatory drugs (NSAIDs). Our 
      patients illustrate that severity of isotretinoin-induced sacroiliitis varies 
      from patient to patient.
CI  - (c) 2019 Wiley Periodicals, Inc.
FAU - Karadag, Serife Gul
AU  - Karadag SG
AD  - Department of Pediatric Rheumatology, Kanuni Sultan Suleyman Research and 
      Training Hospital, University of Health Science, Istanbul, Turkey.
FAU - Sonmez, Hafize Emine
AU  - Sonmez HE
AD  - Department of Pediatric Rheumatology, Kanuni Sultan Suleyman Research and 
      Training Hospital, University of Health Science, Istanbul, Turkey.
FAU - Tanatar, Ayse
AU  - Tanatar A
AD  - Department of Pediatric Rheumatology, Kanuni Sultan Suleyman Research and 
      Training Hospital, University of Health Science, Istanbul, Turkey.
FAU - Cakan, Mustafa
AU  - Cakan M
AD  - Department of Pediatric Rheumatology, Kanuni Sultan Suleyman Research and 
      Training Hospital, University of Health Science, Istanbul, Turkey.
AD  - Department of Pediatric Rheumatology, Sanliurfa Research and Training Hospital, 
      Sanliurfa, Turkey.
FAU - Aktay Ayaz, Nuray
AU  - Aktay Ayaz N
AUID- ORCID: 0000-0003-3594-7387
AD  - Department of Pediatric Rheumatology, Kanuni Sultan Suleyman Research and 
      Training Hospital, University of Health Science, Istanbul, Turkey.
LA  - eng
PT  - Case Reports
PT  - Journal Article
PT  - Review
PT  - Systematic Review
DEP - 20191125
PL  - United States
TA  - Pediatr Dermatol
JT  - Pediatric dermatology
JID - 8406799
RN  - 0 (Dermatologic Agents)
RN  - EH28UP18IF (Isotretinoin)
SB  - IM
MH  - Acne Vulgaris/*drug therapy
MH  - Adolescent
MH  - Dermatologic Agents/*adverse effects/therapeutic use
MH  - Humans
MH  - Isotretinoin/*adverse effects/therapeutic use
MH  - Magnetic Resonance Imaging
MH  - Male
MH  - Sacroiliitis/*chemically induced/diagnostic imaging/drug therapy
OTO - NOTNLM
OT  - acne vulgaris
OT  - isotretinoin
OT  - sacroiliitis
EDAT- 2019/11/26 06:00
MHDA- 2021/01/13 06:00
CRDT- 2019/11/26 06:00
PHST- 2019/11/26 06:00 [pubmed]
PHST- 2021/01/13 06:00 [medline]
PHST- 2019/11/26 06:00 [entrez]
AID - 10.1111/pde.14035 [doi]
PST - ppublish
SO  - Pediatr Dermatol. 2020 Jan;37(1):171-175. doi: 10.1111/pde.14035. Epub 2019 Nov 
      25.