PMID- 31766000
OWN - NLM
STAT- MEDLINE
DCOM- 20210119
LR  - 20210119
IS  - 2211-0356 (Electronic)
IS  - 2211-0348 (Linking)
VI  - 38
DP  - 2020 Feb
TI  - Olfactory identification associates with cognitive function and the third 
      ventricle width in patients with relapsing-remitting multiple sclerosis.
PG  - 101507
LID - S2211-0348(19)30496-1 [pii]
LID - 10.1016/j.msard.2019.101507 [doi]
AB  - BACKGROUND: Olfactory dysfunction is a known clinical feature of multiple 
      sclerosis (MS). Some studies have shown that odor identification impairment is an 
      essential feature associated with cognitive function in MS. This study 
      investigates the relationship between olfactory identification and the disease 
      state, including cognitive function and central brain volume, to evaluate the 
      utility of olfactory identification in the clinical assessment of 
      relapsing-remitting (RR) MS. METHODS: Forty patients with RRMS and 40 healthy 
      controls (HCs) were included. Their olfactory identification was measured using 
      the Odor Stick Identification Test for the Japanese (OSIT-J). Cognitive function 
      was evaluated by the Japanese version of the Wechsler Adult Intelligence Scale, 
      3rd edition (WAIS-III), and depressive mood was evaluated by the Center for 
      Epidemiologic Studies Depression Scale. Magnetic resonance imaging was used to 
      measure the third ventricle width (3rd VW) as a marker of central brain atrophy. 
      RESULTS: RRMS patients had a significantly lower OSIT-J score than HCs. The 
      OSIT-J score was significantly lower in RRMS patients with low processing speed 
      (PS) and working memory (WM) scores than RRMS patients with normal PS or WM 
      scores. The OSIT-J score was significantly related to the PS, WM, and the 3rd VW. 
      The OSIT-J score also showed a mild correlation with the expanded disability 
      status scale and disease duration, but not with the number of clinical attacks or 
      patient's age. CONCLUSIONS: Our results suggest that olfactory identification 
      impairment occurs in association with cognitive dysfunction and central brain 
      atrophy. Thus, olfactory identification is a possible disease marker of RRMS as 
      with cognitive impairment, especially PS, reflecting the diffuse 
      neurodegeneration in RRMS.
CI  - Copyright (c) 2019 Elsevier B.V. All rights reserved.
FAU - Okada, Kazumasa
AU  - Okada K
AD  - Department of Neurology, School of Medicine, University of Occupational and 
      Environmental Health, 1-1 Iseigaoka, Yahatanishi-ku, Kitakyushu 807-8555, Japan. 
      Electronic address: gion@med.uoeh-u.ac.jp.
FAU - Kakeda, Shingo
AU  - Kakeda S
AD  - Department of Diagnostic Radiology, Hirosaki University Graduate School of 
      Medicine, 5 Zaifu-cho, Hirosaki, Aomori 036-8562, Japan.
FAU - Tahara, Masayuki
AU  - Tahara M
AD  - Department of Neurology, Clinical Research Center, National Hospital Organization 
      Utano National Hospital, 8 Ondoyama, Narutaki, Ukyo-ku, Kyoto 616-8255, Japan.
LA  - eng
PT  - Journal Article
DEP - 20191106
PL  - Netherlands
TA  - Mult Scler Relat Disord
JT  - Multiple sclerosis and related disorders
JID - 101580247
RN  - 0 (Biomarkers)
SB  - IM
MH  - Adult
MH  - Atrophy/pathology
MH  - Biomarkers
MH  - Cognitive Dysfunction/etiology/*physiopathology
MH  - Disease Progression
MH  - Female
MH  - Humans
MH  - Magnetic Resonance Imaging
MH  - Male
MH  - Memory, Short-Term/physiology
MH  - Middle Aged
MH  - Multiple Sclerosis, Relapsing-Remitting/complications/diagnostic 
      imaging/*pathology/*physiopathology
MH  - Olfaction Disorders/etiology/*physiopathology
MH  - Reaction Time/physiology
MH  - Third Ventricle/diagnostic imaging/*pathology
MH  - Young Adult
OTO - NOTNLM
OT  - Central brain atrophy
OT  - Cognitive function
OT  - Information processing speed
OT  - Multiple sclerosis
OT  - Olfactory identification
OT  - Third ventricle width
EDAT- 2019/11/26 06:00
MHDA- 2021/01/20 06:00
CRDT- 2019/11/26 06:00
PHST- 2019/09/23 00:00 [received]
PHST- 2019/10/29 00:00 [revised]
PHST- 2019/11/04 00:00 [accepted]
PHST- 2019/11/26 06:00 [pubmed]
PHST- 2021/01/20 06:00 [medline]
PHST- 2019/11/26 06:00 [entrez]
AID - S2211-0348(19)30496-1 [pii]
AID - 10.1016/j.msard.2019.101507 [doi]
PST - ppublish
SO  - Mult Scler Relat Disord. 2020 Feb;38:101507. doi: 10.1016/j.msard.2019.101507. 
      Epub 2019 Nov 6.