PMID- 31766207
OWN - NLM
STAT- MEDLINE
DCOM- 20200707
LR  - 20200707
IS  - 2073-4409 (Electronic)
IS  - 2073-4409 (Linking)
VI  - 8
IP  - 11
DP  - 2019 Nov 13
TI  - Mast Cells in Liver Fibrogenesis.
LID - 10.3390/cells8111429 [doi]
LID - 1429
AB  - Mast cells (MCs) are immune cells of the myeloid lineage that are present in the 
      connective tissue throughout the body and in mucosa tissue. They originate from 
      hematopoietic stem cells in the bone marrow and circulate as MC progenitors in 
      the blood. After migration to various tissues, they differentiate into their 
      mature form, which is characterized by a phenotype containing large granules 
      enriched in a variety of bioactive compounds, including histamine and heparin. 
      These cells can be activated in a receptor-dependent and -independent manner. 
      Particularly, the activation of the high-affinity immunoglobulin E (IgE) 
      receptor, also known as FcepsilonRI, that is expressed on the surface of MCs provoke 
      specific signaling cascades that leads to intracellular calcium influx, 
      activation of different transcription factors, degranulation, and cytokine 
      production. Therefore, MCs modulate many aspects in physiological and 
      pathological conditions, including wound healing, defense against pathogens, 
      immune tolerance, allergy, anaphylaxis, autoimmune defects, inflammation, and 
      infectious and other disorders. In the liver, MCs are mainly associated with 
      connective tissue located in the surrounding of the hepatic arteries, veins, and 
      bile ducts. Recent work has demonstrated a significant increase in MC number 
      during hepatic injury, suggesting an important role of these cells in liver 
      disease and progression. In the present review, we summarize aspects of MC 
      function and mediators in experimental liver injury, their interaction with other 
      hepatic cell types, and their contribution to the pathogenesis of fibrosis.
FAU - Weiskirchen, Ralf
AU  - Weiskirchen R
AUID- ORCID: 0000-0003-3888-0931
AD  - Institute of Molecular Pathobiochemistry, Experimental Gene Therapy and Clinical 
      Chemistry (IFMPEGKC), University Hospital, RWTH Aachen University, D-52074 
      Aachen, Germany.
FAU - Meurer, Steffen K
AU  - Meurer SK
AUID- ORCID: 0000-0003-0821-441X
AD  - Institute of Molecular Pathobiochemistry, Experimental Gene Therapy and Clinical 
      Chemistry (IFMPEGKC), University Hospital, RWTH Aachen University, D-52074 
      Aachen, Germany.
FAU - Liedtke, Christian
AU  - Liedtke C
AUID- ORCID: 0000-0003-4681-7887
AD  - Department of Internal Medicine III, University Hospital, RWTH Aachen University, 
      D-52074 Aachen, Germany.
FAU - Huber, Michael
AU  - Huber M
AD  - Institute of Biochemistry and Molecular Immunology, Medical Faculty, RWTH Aachen 
      University, D-52074 Aachen, Germany.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20191113
PL  - Switzerland
TA  - Cells
JT  - Cells
JID - 101600052
RN  - 0 (Biomarkers)
RN  - 0 (Inflammation Mediators)
SB  - IM
MH  - Animals
MH  - Biomarkers
MH  - Cell Communication
MH  - Disease Management
MH  - Disease Models, Animal
MH  - *Disease Susceptibility
MH  - Drug Discovery
MH  - Humans
MH  - Inflammation/etiology/metabolism/pathology
MH  - Inflammation Mediators
MH  - Liver/immunology/*metabolism/pathology
MH  - Liver Cirrhosis/*etiology/*metabolism/pathology/therapy
MH  - Liver Diseases/etiology/metabolism/pathology
MH  - Mast Cells/drug effects/*immunology/*metabolism
MH  - Signal Transduction
PMC - PMC6912398
OTO - NOTNLM
OT  - TGF-beta
OT  - animal models
OT  - chymase
OT  - degranulation
OT  - fibrosis
OT  - inflammation
OT  - liver
OT  - mast cell
OT  - translational medicine
OT  - tryptase
COIS- The authors declare no conflict of interest.
EDAT- 2019/11/27 06:00
MHDA- 2020/07/08 06:00
PMCR- 2019/11/01
CRDT- 2019/11/27 06:00
PHST- 2019/10/14 00:00 [received]
PHST- 2019/11/05 00:00 [revised]
PHST- 2019/11/10 00:00 [accepted]
PHST- 2019/11/27 06:00 [entrez]
PHST- 2019/11/27 06:00 [pubmed]
PHST- 2020/07/08 06:00 [medline]
PHST- 2019/11/01 00:00 [pmc-release]
AID - cells8111429 [pii]
AID - cells-08-01429 [pii]
AID - 10.3390/cells8111429 [doi]
PST - epublish
SO  - Cells. 2019 Nov 13;8(11):1429. doi: 10.3390/cells8111429.