PMID- 31767009
OWN - NLM
STAT- MEDLINE
DCOM- 20200414
LR  - 20200414
IS  - 1472-6823 (Electronic)
IS  - 1472-6823 (Linking)
VI  - 19
IP  - 1
DP  - 2019 Nov 25
TI  - Associations of serum low-density lipoprotein and systolic blood pressure levels 
      with type 2 diabetic patients with and without peripheral neuropathy: systemic 
      review, meta-analysis and meta-regression analysis of observational studies.
PG  - 125
LID - 10.1186/s12902-019-0453-5 [doi]
LID - 125
AB  - BACKGROUND: Compositional abnormalities in lipoproteins and cardiovascular risk 
      factors play an important role in the progression of diabetic peripheral 
      neuropathy (DPN). This systematic review aimed to estimate the predicting value 
      of low-density lipoprotein (LDL) and systolic blood pressure (SBP) level in 
      type-2 diabetes mellitus (T2DM) patients with and without peripheral neuropathy. 
      We also tried to determine whether LDL and SBP are associated with an increased 
      collision risk of DPN. METHODS: A systematic search was conducted for eligible 
      publications which explored the LDL and SBP level in T2DM patients with and 
      without peripheral neuropathy. The quality of the included studies was assessed 
      by the QUADAS-2 tool. The standardized mean difference (SMD) with 95% CI of LDL 
      and SBP level were pooled to assess the correlation between LDL and SBP level 
      with DPN. We performed random effects meta-regression analyses to investigate 
      factors associated with an increased collision risk of DPN. RESULTS: There was a 
      significant association between LDL and SBP with poor prognosis of DPN in those 
      included studies (I(2) = 88.1% and I(2) = 84.9%, respectively, Both P < 0.001). 
      European T2DM patients have higher serum level of LDL in compare with the 
      European DPN patients (SMD = 0.16, 95% CI: - 0.06 - 0.38; P < 0.001). SBP level 
      was associated with a 2.6-fold decrease in non-DPN patients of T2DM 
      (SMD = - 2.63, 95% CI: - 4.00 - -1.27, P < 0.001). Old age European T2DM patients 
      have significantly high risk for diabetes drivers. Furthermore, the results of 
      the case-control study design model are more precise to show the accuracy of SBP 
      in Asian T2DM patients. CONCLUSION: Our finding supports the LDL and SBP status 
      could be associated with increased risk of peripheral neuropathy in T2DM 
      patients.
FAU - Naqvi, Syed Shah Zaman Haider
AU  - Naqvi SSZH
AD  - Department of Diabetes and Endocrinology, Affiliated Hospital of Southwest 
      Medical University, Luzhou, Sichuan Province, People's Republic of China.
FAU - Imani, Saber
AU  - Imani S
AD  - Department of Oncology, Affiliated Hospital of Southwest Medical University, 
      Luzhou, Sichuan Province, People's Republic of China.
FAU - Hosseinifard, Hossein
AU  - Hosseinifard H
AD  - Research Center for Evidence Based Medicine (RCEBM), Tabriz University of Medical 
      Sciences, Tabriz, Iran.
FAU - Wen, Qing-Lian
AU  - Wen QL
AD  - Department of Oncology, Affiliated Hospital of Southwest Medical University, 
      Luzhou, Sichuan Province, People's Republic of China.
FAU - Shahzad, M Naveed
AU  - Shahzad MN
AD  - Stem Cell Laboratory, Department of Hematology, Affiliated Hospital of Southwest 
      Medical University, Luzhou, Sichuan Province, People's Republic of China.
FAU - Ijaz, Iqra
AU  - Ijaz I
AD  - Sichuan Provincial Center for Gynecological and Breast Diseases, Southwest 
      Medical University, Luzhou, Sichuan Province, People's Republic of China.
FAU - Deng, Youcai
AU  - Deng Y
AD  - Institute of Materia Medical, College of Pharmacy, Army Medical University (Third 
      Military Medical University), Chongqing, People's Republic of China.
FAU - Guo, Man
AU  - Guo M
AD  - Luzhou Key Laboratory of Cardiovascular and Metabolic Diseases, Affiliated 
      Hospital of Southwest Medical University, Luzhou, Sichuan Province, People's 
      Republic of China.
FAU - Xu, Yong
AU  - Xu Y
AD  - Department of Diabetes and Endocrinology, Affiliated Hospital of Southwest 
      Medical University, Luzhou, Sichuan Province, People's Republic of China. 
      xywyll@aliyun.com.
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
PT  - Systematic Review
DEP - 20191125
PL  - England
TA  - BMC Endocr Disord
JT  - BMC endocrine disorders
JID - 101088676
RN  - 0 (Lipoproteins, LDL)
SB  - IM
MH  - *Blood Pressure
MH  - Case-Control Studies
MH  - Diabetes Mellitus, Type 2/*complications
MH  - Diabetic Neuropathies/blood/etiology/*physiopathology
MH  - Humans
MH  - Lipoproteins, LDL/*blood
MH  - Observational Studies as Topic
MH  - Prognosis
MH  - *Systole
PMC - PMC6878654
OTO - NOTNLM
OT  - Diabetic peripheral neuropathy
OT  - Low-density lipoprotein
OT  - Meta-analysis
OT  - Meta-regression
OT  - Systolic blood pressure
OT  - Type 2 diabetes
COIS- The authors declare that they have no competing interests.
EDAT- 2019/11/27 06:00
MHDA- 2020/04/15 06:00
PMCR- 2019/11/25
CRDT- 2019/11/27 06:00
PHST- 2019/07/10 00:00 [received]
PHST- 2019/10/31 00:00 [accepted]
PHST- 2019/11/27 06:00 [entrez]
PHST- 2019/11/27 06:00 [pubmed]
PHST- 2020/04/15 06:00 [medline]
PHST- 2019/11/25 00:00 [pmc-release]
AID - 10.1186/s12902-019-0453-5 [pii]
AID - 453 [pii]
AID - 10.1186/s12902-019-0453-5 [doi]
PST - epublish
SO  - BMC Endocr Disord. 2019 Nov 25;19(1):125. doi: 10.1186/s12902-019-0453-5.