PMID- 31767034
OWN - NLM
STAT- MEDLINE
DCOM- 20200916
LR  - 20200916
IS  - 1479-5876 (Electronic)
IS  - 1479-5876 (Linking)
VI  - 17
IP  - 1
DP  - 2019 Nov 25
TI  - The pathogenesis of renal injury and treatment in light chain deposition disease.
PG  - 387
LID - 10.1186/s12967-019-02147-4 [doi]
LID - 387
AB  - Light chain deposition disease (LCDD) is a rare clinical disorder. The deposition 
      of light chain immunoglobulins mainly affects the kidneys, which have different 
      characteristics than other tissues. To date, the therapeutic approach for the 
      treatment of LCDD has no evidence-based consensus, and clinical experience of 
      reported cases guides current disease management strategies. The present 
      systematic review investigates and summarizes the pathological mechanisms of 
      renal injury and the subsequent treatments for LCDD.
FAU - Wang, Qi
AU  - Wang Q
AD  - Department of Nephrology, The Second Affiliated Hospital of Nanchang University, 
      No. 1, Minde Road, Donghu District, Nanchang, Zip Code: 330006, People's Republic 
      of China.
AD  - Medical Center of the Graduate School, Nanchang University, Nanchang, China.
FAU - Jiang, Fang
AU  - Jiang F
AD  - Department of Nephrology, People's Hospital of Xinyu City, No. 369, Xinxin North 
      Avenue, High-tech District, Xinyu, People's Republic of China.
FAU - Xu, Gaosi
AU  - Xu G
AD  - Department of Nephrology, The Second Affiliated Hospital of Nanchang University, 
      No. 1, Minde Road, Donghu District, Nanchang, Zip Code: 330006, People's Republic 
      of China. gaosixu@163.com.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20191125
PL  - England
TA  - J Transl Med
JT  - Journal of translational medicine
JID - 101190741
RN  - 0 (Immunoglobulin Light Chains)
SB  - IM
MH  - Animals
MH  - Humans
MH  - Immunoglobulin Light Chains/*metabolism
MH  - Kidney/*injuries/pathology/ultrastructure
MH  - Models, Biological
PMC - PMC6878616
OTO - NOTNLM
OT  - Biopsy
OT  - Chemotherapy
OT  - Light chain deposition disease
OT  - Renal injury
OT  - Treatment
COIS- The authors declare that they have no competing interests.
EDAT- 2019/11/27 06:00
MHDA- 2020/09/17 06:00
PMCR- 2019/11/25
CRDT- 2019/11/27 06:00
PHST- 2019/05/19 00:00 [received]
PHST- 2019/11/19 00:00 [accepted]
PHST- 2019/11/27 06:00 [entrez]
PHST- 2019/11/27 06:00 [pubmed]
PHST- 2020/09/17 06:00 [medline]
PHST- 2019/11/25 00:00 [pmc-release]
AID - 10.1186/s12967-019-02147-4 [pii]
AID - 2147 [pii]
AID - 10.1186/s12967-019-02147-4 [doi]
PST - epublish
SO  - J Transl Med. 2019 Nov 25;17(1):387. doi: 10.1186/s12967-019-02147-4.