PMID- 31767085
OWN - NLM
STAT- MEDLINE
DCOM- 20200211
LR  - 20200211
IS  - 1873-2542 (Electronic)
IS  - 0378-1135 (Linking)
VI  - 239
DP  - 2019 Dec
TI  - Efficacy of concurrent vaccination with modified-live PRRSV-1 and PRRSV-2 
      vaccines against heterologous dual PRRSV-1 and PRRSV-2 challenge in late term 
      pregnancy gilts.
PG  - 108497
LID - S0378-1135(19)30760-6 [pii]
LID - 10.1016/j.vetmic.2019.108497 [doi]
AB  - The objective of this study was to evaluate the effect of concurrent vaccination 
      with a porcine reproductive and respiratory syndrome virus (PRRSV)-1 
      modified-live virus (MLV) vaccine and a PRRSV-2 MLV vaccine against a dual 
      heterologous PRRSV-1 and PRRSV-2 challenge in late term pregnancy gilts. Gilts 
      were concurrently administered PRRSV-1 and PRRSV-2 MLV vaccines at 21 days prior 
      to breeding at separate anatomical sites and were inoculated intranasally with 
      both PRRSV types at 93 days of gestation. Vaccinated gilts had a higher number of 
      live-born and weaned pigs, and a decrease in stillbirths compared to the 
      unvaccinated control group following a dual challenge. Concurrent vaccination 
      resulted also in the reduction of both PRRSV-1 and PRRSV-2 viremia which 
      correlated with an increase in the number of PRRSV-1 and PRRSV-2 specific 
      interferon-gamma secreting cells (IFN-gamma-SC). We believe the T cell responses 
      contributed to the reduction of both PRRSV-1 and PRRSV-2 viremia. The results 
      presented here demonstrate that concurrent vaccination with PRRSV-1 and PRRSV-2 
      MLV vaccines improves reproductive performance, reduces viremia of PRRSV-1 and 
      PRRSV-2, and induces protective T cell reactions against dual PRRSV-1 and PRRSV-2 
      challenge in late term pregnancy gilts without local and systemic adverse 
      reactions related to concurrent vaccination.
CI  - Copyright (c) 2019 Elsevier B.V. All rights reserved.
FAU - Yang, Siyeon
AU  - Yang S
AD  - Department of Veterinary Pathology, College of Veterinary Medicine, Seoul 
      National University, 1 Gwanak-ro, Gwanak-gu, Seoul, 08826, Republic of Korea.
FAU - Oh, Taehwan
AU  - Oh T
AD  - Department of Veterinary Pathology, College of Veterinary Medicine, Seoul 
      National University, 1 Gwanak-ro, Gwanak-gu, Seoul, 08826, Republic of Korea.
FAU - Kang, Ikjae
AU  - Kang I
AD  - Department of Veterinary Pathology, College of Veterinary Medicine, Seoul 
      National University, 1 Gwanak-ro, Gwanak-gu, Seoul, 08826, Republic of Korea.
FAU - Park, Su-Jin
AU  - Park SJ
AD  - Department of Veterinary Pathology, College of Veterinary Medicine, Seoul 
      National University, 1 Gwanak-ro, Gwanak-gu, Seoul, 08826, Republic of Korea.
FAU - Chae, Chanhee
AU  - Chae C
AD  - Department of Veterinary Pathology, College of Veterinary Medicine, Seoul 
      National University, 1 Gwanak-ro, Gwanak-gu, Seoul, 08826, Republic of Korea. 
      Electronic address: swine@snu.ac.kr.
LA  - eng
PT  - Journal Article
DEP - 20191106
PL  - Netherlands
TA  - Vet Microbiol
JT  - Veterinary microbiology
JID - 7705469
RN  - 0 (Antibodies, Viral)
RN  - 0 (Vaccines, Attenuated)
RN  - 0 (Viral Vaccines)
SB  - IM
MH  - Animals
MH  - Antibodies, Viral/blood
MH  - Female
MH  - Porcine Reproductive and Respiratory Syndrome/*prevention & control
MH  - Porcine respiratory and reproductive syndrome virus/*immunology
MH  - Pregnancy
MH  - Pregnancy Outcome/veterinary
MH  - Swine
MH  - Vaccination/standards/*veterinary
MH  - Vaccines, Attenuated/*immunology
MH  - Viral Vaccines/*immunology
MH  - Viremia/prevention & control/veterinary
OTO - NOTNLM
OT  - Modified-Live virus vaccine
OT  - Porcine reproductive and respiratory syndrome virus
OT  - Reproductive failure
OT  - Sow
OT  - Vaccine
EDAT- 2019/11/27 06:00
MHDA- 2020/02/12 06:00
CRDT- 2019/11/27 06:00
PHST- 2019/06/28 00:00 [received]
PHST- 2019/10/29 00:00 [revised]
PHST- 2019/11/01 00:00 [accepted]
PHST- 2019/11/27 06:00 [entrez]
PHST- 2019/11/27 06:00 [pubmed]
PHST- 2020/02/12 06:00 [medline]
AID - S0378-1135(19)30760-6 [pii]
AID - 10.1016/j.vetmic.2019.108497 [doi]
PST - ppublish
SO  - Vet Microbiol. 2019 Dec;239:108497. doi: 10.1016/j.vetmic.2019.108497. Epub 2019 
      Nov 6.