PMID- 31767236 OWN - NLM STAT- MEDLINE DCOM- 20200310 LR - 20200310 IS - 1873-6424 (Electronic) IS - 0269-7491 (Linking) VI - 257 DP - 2020 Feb TI - Associations of a mixture of urinary phthalate metabolites with blood lipid traits: A repeated-measures pilot study. PG - 113509 LID - S0269-7491(19)33806-0 [pii] LID - 10.1016/j.envpol.2019.113509 [doi] AB - Evidence is available about the associations of phthalates or their metabolites with blood lipids, however, the mixture effects of multiple phthalate metabolites on blood lipid traits remain largely unknown. In this pilot study, 106 individuals at three age groups of <18, 18- and >/=60 years were recruited from the residents (n = 1240) who were randomly selected from two communities in Wuhan city, China. The participants completed the questionnaire survey and physical examination as well as provided urine samples in the winter of 2014 and the summer of 2015. We measured urinary levels of nine phthalate metabolites using a high-performance liquid chromatography-tandem mass spectrometry. We estimated the associations of individual phthalate metabolite with blood lipid traits by linear mixed effect (LME) models, and assessed the overall association of the mixture of nine phthalate metabolites with blood lipid traits using Bayesian kernel machine regression (BKMR) models. LME models revealed the negative association of urinary mono-2-ethylhexyl phthalate (MEHP) with total cholesterol (TC) as well as of urinary mono-benzyl phthalate or urinary MEHP with low density lipoprotein cholesterol (LDL-C). BKMR models revealed the negative overall association of the mixture of nine phthalate metabolites with TC or LDL-C, and DEHP metabolites (especially MEHP) had a greater contribution to TC or LDL-C levels than non-DEHP metabolites. The findings indicated the negative overall association of the mixture of nine phthalate metabolites with TC or LDL-C. Among nine phthalate metabolites, MEHP was the most important component for the changes of TC or LDL-C levels, implying that phthalates exposure may disrupt lipid metabolism in the body. CI - Copyright (c) 2019 Elsevier Ltd. All rights reserved. FAU - Zhu, Qingqing AU - Zhu Q AD - Department of Occupational and Environmental Health, PR China; Key Laboratory of Environment and Health, Ministry of Education & Ministry of Environmental Protection, State Key Laboratory of Environmental Health (Incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Hangkong Road 13, Wuhan 430030, Hubei, PR China. FAU - Hou, Jian AU - Hou J AD - Department of Occupational and Environmental Health, PR China; Key Laboratory of Environment and Health, Ministry of Education & Ministry of Environmental Protection, State Key Laboratory of Environmental Health (Incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Hangkong Road 13, Wuhan 430030, Hubei, PR China. FAU - Yin, Wenjun AU - Yin W AD - Department of Occupational and Environmental Health, PR China; Key Laboratory of Environment and Health, Ministry of Education & Ministry of Environmental Protection, State Key Laboratory of Environmental Health (Incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Hangkong Road 13, Wuhan 430030, Hubei, PR China. FAU - Ye, Fang AU - Ye F AD - Department of Occupational and Environmental Health, PR China; Key Laboratory of Environment and Health, Ministry of Education & Ministry of Environmental Protection, State Key Laboratory of Environmental Health (Incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Hangkong Road 13, Wuhan 430030, Hubei, PR China. FAU - Xu, Tian AU - Xu T AD - Department of Occupational and Environmental Health, PR China; Key Laboratory of Environment and Health, Ministry of Education & Ministry of Environmental Protection, State Key Laboratory of Environmental Health (Incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Hangkong Road 13, Wuhan 430030, Hubei, PR China. FAU - Cheng, Juan AU - Cheng J AD - Department of Occupational and Environmental Health, PR China; Key Laboratory of Environment and Health, Ministry of Education & Ministry of Environmental Protection, State Key Laboratory of Environmental Health (Incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Hangkong Road 13, Wuhan 430030, Hubei, PR China. FAU - Yu, Zhiqiang AU - Yu Z AD - State Key Laboratory of Organic Geochemistry, Guangdong Key Laboratory of Environment and Resources, Guangzhou Institute of Geochemistry, Chinese Academy of Sciences, Guangzhou, 510640, PR China. FAU - Wang, Lin AU - Wang L AD - Key Laboratory of Environment and Health, Ministry of Education & Ministry of Environmental Protection, State Key Laboratory of Environmental Health (Incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Hangkong Road 13, Wuhan 430030, Hubei, PR China. Electronic address: lwangtj@163.com. FAU - Yuan, Jing AU - Yuan J AD - Department of Occupational and Environmental Health, PR China; Key Laboratory of Environment and Health, Ministry of Education & Ministry of Environmental Protection, State Key Laboratory of Environmental Health (Incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Hangkong Road 13, Wuhan 430030, Hubei, PR China. Electronic address: jyuan@tjh.tjmu.edu.cn. LA - eng PT - Journal Article DEP - 20191116 PL - England TA - Environ Pollut JT - Environmental pollution (Barking, Essex : 1987) JID - 8804476 RN - 0 (Hydrocarbons, Aromatic) RN - 0 (Lipids) RN - 0 (Phthalic Acids) RN - 27NM8BNV1K (mono-benzyl phthalate) RN - 6O7F7IX66E (phthalic acid) RN - C42K0PH13C (Diethylhexyl Phthalate) RN - FU2EWB60RT (mono-(2-ethylhexyl)phthalate) SB - IM MH - Bayes Theorem MH - China MH - Chromatography, High Pressure Liquid MH - Diethylhexyl Phthalate/analogs & derivatives MH - Environmental Exposure/*analysis MH - Female MH - Humans MH - Hydrocarbons, Aromatic MH - Linear Models MH - Lipids MH - Male MH - Middle Aged MH - Phthalic Acids/*urine MH - Pilot Projects OTO - NOTNLM OT - Bayesian kernel machine regression model OT - Lipid traits OT - Phthalates EDAT- 2019/11/27 06:00 MHDA- 2020/03/11 06:00 CRDT- 2019/11/27 06:00 PHST- 2019/07/13 00:00 [received] PHST- 2019/10/05 00:00 [revised] PHST- 2019/10/27 00:00 [accepted] PHST- 2019/11/27 06:00 [pubmed] PHST- 2020/03/11 06:00 [medline] PHST- 2019/11/27 06:00 [entrez] AID - S0269-7491(19)33806-0 [pii] AID - 10.1016/j.envpol.2019.113509 [doi] PST - ppublish SO - Environ Pollut. 2020 Feb;257:113509. doi: 10.1016/j.envpol.2019.113509. Epub 2019 Nov 16.