PMID- 31767267
OWN - NLM
STAT- MEDLINE
DCOM- 20201019
LR  - 20201019
IS  - 1879-3061 (Electronic)
IS  - 1043-2760 (Linking)
VI  - 31
IP  - 1
DP  - 2020 Jan
TI  - A Novel Mechanism for Th17 Inflammation in Human Type 2 Diabetes Mellitus.
PG  - 1-2
LID - S1043-2760(19)30224-3 [pii]
LID - 10.1016/j.tem.2019.11.002 [doi]
AB  - In their recent study, Nicholas et al. challenge the current dogma that T cell 
      inflammation must be fueled by glycolysis and demonstrate a novel metabolic 
      mechanism for Th17 inflammation in human type 2 diabetes mellitus (T2DM): a 
      combination of increased environmental long-chain fatty acid metabolites coupled 
      with decreased fatty acid oxidation.
CI  - Copyright (c) 2019 Elsevier Ltd. All rights reserved.
FAU - Kiernan, Kaitlin
AU  - Kiernan K
AD  - Department of Immunology, Duke University School of Medicine, Durham, NC, USA.
FAU - MacIver, Nancie J
AU  - MacIver NJ
AD  - Department of Immunology, Duke University School of Medicine, Durham, NC, USA; 
      Department of Pediatrics, Duke University School of Medicine, Durham, NC, USA; 
      Department of Pharmacology and Cancer Biology, Duke University School of 
      Medicine, Durham, NC, USA. Electronic address: nancie.maciver@duke.edu.
LA  - eng
GR  - T32 AI052077/AI/NIAID NIH HHS/United States
PT  - Comment
PT  - Journal Article
DEP - 20191122
PL  - United States
TA  - Trends Endocrinol Metab
JT  - Trends in endocrinology and metabolism: TEM
JID - 9001516
RN  - 0 (Fatty Acids)
RN  - 0 (Interleukin-17)
SB  - IM
CON - Biomed Pharmacother. 2018 May;101:287-292. PMID: 29499402
MH  - *Diabetes Mellitus, Type 2
MH  - Fatty Acids
MH  - Humans
MH  - Inflammation
MH  - *Interleukin-17
MH  - Th17 Cells
OTO - NOTNLM
OT  - Th17
OT  - fatty acid oxidation
OT  - metabolism
OT  - obesity
OT  - type 2 diabetes
EDAT- 2019/11/27 06:00
MHDA- 2020/10/21 06:00
CRDT- 2019/11/27 06:00
PHST- 2019/10/17 00:00 [received]
PHST- 2019/11/06 00:00 [accepted]
PHST- 2019/11/27 06:00 [pubmed]
PHST- 2020/10/21 06:00 [medline]
PHST- 2019/11/27 06:00 [entrez]
AID - S1043-2760(19)30224-3 [pii]
AID - 10.1016/j.tem.2019.11.002 [doi]
PST - ppublish
SO  - Trends Endocrinol Metab. 2020 Jan;31(1):1-2. doi: 10.1016/j.tem.2019.11.002. Epub 
      2019 Nov 22.