PMID- 31768902
OWN - NLM
STAT- MEDLINE
DCOM- 20211122
LR  - 20240130
IS  - 1532-6551 (Electronic)
IS  - 1071-3581 (Linking)
VI  - 27
IP  - 5
DP  - 2020 Oct
TI  - Effect of proton pump inhibitors on Rubidium-82 gastric uptake using positron 
      emission tomography myocardial perfusion imaging.
PG  - 1443-1451
LID - 10.1007/s12350-019-01954-y [doi]
AB  - BACKGROUND: Rb-82 positron emission tomography (PET) myocardial perfusion imaging 
      (MPI) is a robust tool for the evaluation of coronary artery disease (CAD). 
      However, gastric uptake and spillover can be seen in 10% of Rb-82 PET MPI 
      studies, commonly affecting the inferior wall, and can preclude the accurate 
      identification of myocardial ischemia. We sought to understand the relationship 
      between Rb-82 gastric uptake and the use of proton pump inhibitors (PPI). 
      METHODS: 600 consecutive patients who presented for a clinically indicated Rb-82 
      PET MPI study were prospectively enrolled. In addition to the clinical history, 
      PPI use was ascertained (medication, dose, frequency and duration of use, and 
      time of last dose). Patients were categorized as PPI and non-PPI users. Rb-82 
      uptake in the gastrium, myocardium, and liver were measured at rest. Absolute 
      uptake values and gastric:hepatic ratios were compared in PPI and non-PPI users. 
      RESULT: Of 600 enrolled patients, 181 (30.2%) patients were using PPI. The 
      gastric Rb-82 uptake in PPI users was 23% higher than non-PPI users (146 +/- 52 
      kBq/cc vs 119 +/- 40 kBq/cc, respectively; P < 0.001). The resting gastric:hepatic 
      Rb-82 uptake ratio was also 23% higher in PPI vs non-PPI users (2.7 +/- 1.0 vs 
      2.2 +/- 0.8, respectively; P < 0.001). CONCLUSION: The gastric uptake of Rb-82 
      appears to be greater in patients actively using PPI and may identify a group who 
      might be at greater risk of non-diagnostic Rb-82 PET MPI.
FAU - Alzahrani, Atif H
AU  - Alzahrani AH
AD  - Department of Medicine (Cardiology), University of Ottawa Heart Institute, 40 
      Ruskin Street, Ottawa, ON, K1Y 4W7, Canada.
AD  - King Saud bin Abdulaziz University for Health Sciences, Jeddah, Saudi Arabia.
FAU - Arasaratnam, Punitha
AU  - Arasaratnam P
AD  - Department of Medicine (Cardiology), University of Ottawa Heart Institute, 40 
      Ruskin Street, Ottawa, ON, K1Y 4W7, Canada.
FAU - Massalha, Samia
AU  - Massalha S
AD  - Department of Medicine (Cardiology), University of Ottawa Heart Institute, 40 
      Ruskin Street, Ottawa, ON, K1Y 4W7, Canada.
FAU - Alenazy, Ali
AU  - Alenazy A
AD  - Department of Medicine (Cardiology), University of Ottawa Heart Institute, 40 
      Ruskin Street, Ottawa, ON, K1Y 4W7, Canada.
FAU - Lee, Alex
AU  - Lee A
AD  - Department of Medicine (Cardiology), University of Ottawa Heart Institute, 40 
      Ruskin Street, Ottawa, ON, K1Y 4W7, Canada.
FAU - Clarkin, Owen
AU  - Clarkin O
AD  - Department of Medicine (Cardiology), University of Ottawa Heart Institute, 40 
      Ruskin Street, Ottawa, ON, K1Y 4W7, Canada.
FAU - deKemp, Robert A
AU  - deKemp RA
AD  - Department of Medicine (Cardiology), University of Ottawa Heart Institute, 40 
      Ruskin Street, Ottawa, ON, K1Y 4W7, Canada.
FAU - Hossain, Alomgir
AU  - Hossain A
AD  - Department of Epidemiology, University of Ottawa, Ottawa, Canada.
FAU - Beanlands, Rob S
AU  - Beanlands RS
AD  - Department of Medicine (Cardiology), University of Ottawa Heart Institute, 40 
      Ruskin Street, Ottawa, ON, K1Y 4W7, Canada.
AD  - Department of Radiology, University of Ottawa, Ottawa, Canada.
FAU - Ruddy, Terrence D
AU  - Ruddy TD
AD  - Department of Medicine (Cardiology), University of Ottawa Heart Institute, 40 
      Ruskin Street, Ottawa, ON, K1Y 4W7, Canada.
AD  - Department of Radiology, University of Ottawa, Ottawa, Canada.
FAU - Chow, Benjamin J W
AU  - Chow BJW
AD  - Department of Medicine (Cardiology), University of Ottawa Heart Institute, 40 
      Ruskin Street, Ottawa, ON, K1Y 4W7, Canada. bchow@ottawaheart.ca.
AD  - Department of Radiology, University of Ottawa, Ottawa, Canada. 
      bchow@ottawaheart.ca.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20191125
PL  - United States
TA  - J Nucl Cardiol
JT  - Journal of nuclear cardiology : official publication of the American Society of 
      Nuclear Cardiology
JID - 9423534
RN  - 0 (Proton Pump Inhibitors)
RN  - 0 (Rubidium Radioisotopes)
RN  - 9K730EL8KU (Rubidium-82)
SB  - IM
CIN - J Nucl Cardiol. 2020 Oct;27(5):1452-1455. PMID: 32095936
MH  - Aged
MH  - Coronary Artery Disease/complications/*diagnostic imaging/metabolism
MH  - Female
MH  - Gastric Mucosa/diagnostic imaging/*metabolism
MH  - Humans
MH  - Liver/diagnostic imaging/*metabolism
MH  - Male
MH  - Middle Aged
MH  - Myocardial Perfusion Imaging
MH  - Myocardium/*metabolism
MH  - Positron-Emission Tomography
MH  - Prospective Studies
MH  - Proton Pump Inhibitors/*administration & dosage
MH  - Rubidium Radioisotopes/*pharmacokinetics
OTO - NOTNLM
OT  - Gastric spillover
OT  - Image quality
OT  - Myocardial perfusion imaging
OT  - Positron emission tomography
OT  - Proton pump inhibitor
EDAT- 2019/11/27 06:00
MHDA- 2021/11/23 06:00
CRDT- 2019/11/27 06:00
PHST- 2019/02/20 00:00 [received]
PHST- 2019/08/17 00:00 [accepted]
PHST- 2019/07/24 00:00 [revised]
PHST- 2019/11/27 06:00 [pubmed]
PHST- 2021/11/23 06:00 [medline]
PHST- 2019/11/27 06:00 [entrez]
AID - S1071-3581(23)02036-6 [pii]
AID - 10.1007/s12350-019-01954-y [doi]
PST - ppublish
SO  - J Nucl Cardiol. 2020 Oct;27(5):1443-1451. doi: 10.1007/s12350-019-01954-y. Epub 
      2019 Nov 25.