PMID- 31769238 OWN - NLM STAT- MEDLINE DCOM- 20210604 LR - 20210604 IS - 2233-6087 (Electronic) IS - 2233-6079 (Print) IS - 2233-6079 (Linking) VI - 44 IP - 3 DP - 2020 Jun TI - Association between Higher Blood Pressure and Risk of Diabetes Mellitus in Middle-Aged and Elderly Chinese Adults. PG - 436-445 LID - 10.4093/dmj.2019.0081 [doi] AB - BACKGROUND: To examine the prospective association between higher blood pressure (BP) and risk of type 2 diabetes mellitus (T2DM) in middle-aged and elderly Chinese adults. METHODS: A total of 9,642 middle-aged and elderly Chinese adults (>/=45 years old; 47.30% men) without diabetes from the China Health and Retirement Longitudinal Study were included for analyses. Participants were categorized into three groups: normal BP, prehypertension, and hypertension, according to the 2010 Chinese Guidelines for the Management of Hypertension. The incidence of T2DM was determined by self-reported physician diagnosis during two follow-up surveys conducted in 2013 to 2014 and 2015 to 2016. RESULTS: During the 4-year follow-up, 429 participants (4.45%) developed T2DM, including 3.51% of the men and 5.29% of the women. The incidence rates of T2DM were 2.57%, 3.75%, and 6.71% in the normal BP, prehypertension, and hypertension groups, respectively. After adjustment for age, sex, education level, residence, smoking status, alcohol consumption, body mass index, waist circumference, and dyslipidemia, both prehypertension (odds ratio [OR], 1.32; 95% confidence interval [CI], 0.98 to 1.77) and hypertension (OR, 2.02; 95% CI, 1.54 to 2.64) were associated with increased risk of T2DM, compared to those with a normal BP. The ORs associated with T2DM were 1.08 (95% CI, 1.03 to 1.13) for an increase of 10 mm Hg in systolic BP and 1.06 (95% CI, 1.01 to 1.10) for an increase of 5 mm Hg in diastolic BP. CONCLUSION: Higher BP is a risk factor for T2DM in middle-aged and elderly Chines. It may be a potential target for diabetes prevention. CI - Copyright (c) 2020 Korean Diabetes Association. FAU - Yang, Xue AU - Yang X AUID- ORCID: 0000-0002-9775-5009 AD - Department of Epidemiology and Biostatistics, West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu, China. FAU - Chen, Jian AU - Chen J AD - Department of Epidemiology and Biostatistics, School of Public Health, Chengdu Medical College, Chengdu, China. FAU - Pan, An AU - Pan A AD - Department of Epidemiology and Biostatistics, Ministry of Education Key Laboratory of Environment and Health and State Key Laboratory of Environmental Health (Incubation), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. FAU - Wu, Jason H Y AU - Wu JHY AD - The George Institute for Global Health, University of New South Wales, Sydney, Australia. FAU - Zhao, Fei AU - Zhao F AD - Department of Epidemiology and Biostatistics, West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu, China. FAU - Xie, Yue AU - Xie Y AD - Department of Epidemiology and Biostatistics, West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu, China. FAU - Wang, Yi AU - Wang Y AD - Department of Epidemiology and Biostatistics, Ministry of Education Key Laboratory of Environment and Health and State Key Laboratory of Environmental Health (Incubation), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. FAU - Ye, Yi AU - Ye Y AD - Department of Epidemiology and Biostatistics, Ministry of Education Key Laboratory of Environment and Health and State Key Laboratory of Environmental Health (Incubation), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. FAU - Pan, Xiong Fei AU - Pan XF AUID- ORCID: 0000-0002-9350-9230 AD - Department of Epidemiology and Biostatistics, Ministry of Education Key Laboratory of Environment and Health and State Key Laboratory of Environmental Health (Incubation), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. AD - The George Institute for Global Health, University of New South Wales, Sydney, Australia. pxiongfei@gmail.com. FAU - Yang, Chun Xia AU - Yang CX AUID- ORCID: 0000-0002-8548-2381 AD - Department of Epidemiology and Biostatistics, West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu, China. chunxia815@163.com. LA - eng GR - 2017YFC0907504/National Key Research and Development Program of China/International GR - 20180062/International Postdoctoral Exchange Fellowship Program of the China Postdoctoral Council/International PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20191114 PL - Korea (South) TA - Diabetes Metab J JT - Diabetes & metabolism journal JID - 101556588 SB - IM MH - Aged MH - Blood Pressure MH - Body Mass Index MH - China/epidemiology MH - Comorbidity MH - Diabetes Mellitus, Type 2/*epidemiology/*etiology MH - Female MH - Follow-Up Studies MH - Humans MH - Hypertension/*complications MH - Incidence MH - Longitudinal Studies MH - Male MH - Middle Aged MH - Prehypertension/*complications MH - Prospective Studies MH - Risk Factors MH - Self Report MH - Waist Circumference PMC - PMC7332331 OTO - NOTNLM OT - Blood pressure OT - China OT - Diabetes mellitus OT - Hypertension COIS- No potential conflict of interest relevant to this article was reported. EDAT- 2019/11/27 06:00 MHDA- 2021/06/05 06:00 PMCR- 2020/06/01 CRDT- 2019/11/27 06:00 PHST- 2019/05/01 00:00 [received] PHST- 2019/06/18 00:00 [accepted] PHST- 2019/11/27 06:00 [pubmed] PHST- 2021/06/05 06:00 [medline] PHST- 2019/11/27 06:00 [entrez] PHST- 2020/06/01 00:00 [pmc-release] AID - 43.e64 [pii] AID - 10.4093/dmj.2019.0081 [doi] PST - ppublish SO - Diabetes Metab J. 2020 Jun;44(3):436-445. doi: 10.4093/dmj.2019.0081. Epub 2019 Nov 14.