PMID- 31769393
OWN - NLM
STAT- MEDLINE
DCOM- 20200421
LR  - 20210110
IS  - 1476-1645 (Electronic)
IS  - 0002-9637 (Print)
IS  - 0002-9637 (Linking)
VI  - 102
IP  - 1
DP  - 2020 Jan
TI  - Frequency and Clinical Significance of Localized Adverse Events following Mass 
      Drug Administration for Lymphatic Filariasis in an Endemic Area in South India.
PG  - 96-99
LID - 10.4269/ajtmh.19-0532 [doi]
AB  - Fear of adverse events (AEs) negatively affects compliance to mass drug 
      administration (MDA) for lymphatic filariasis (LF) elimination program. Systemic 
      AEs are believed to occur because of killing of microfilariae, whereas localized 
      soft tissue reactions might be due to the death of adult worms following therapy. 
      Most AEs are mild and self-limited. However, localized AEs are sometimes more 
      significant and of concern to participants. Here, we describe localized AEs that 
      were noted during a large community study that evaluated the safety of a 
      triple-drug regimen (ivermectin, diethylcarbamazine, and albendazole) for the 
      treatment of LF in India. We have also discussed the importance of timely 
      detection and careful management of AEs for preserving community confidence in 
      MDA.
FAU - Kuttiatt, Vijesh Sreedhar
AU  - Kuttiatt VS
AD  - ICMR-Vector Control Research Centre, Puducherry, India.
FAU - Somani, Roopali K
AU  - Somani RK
AD  - ICMR-Vector Control Research Centre, Puducherry, India.
FAU - Swaminathan, Subramanian
AU  - Swaminathan S
AD  - ICMR-Vector Control Research Centre, Puducherry, India.
FAU - Krishnamoorthy, Kaliannagounder
AU  - Krishnamoorthy K
AD  - ICMR-Vector Control Research Centre, Puducherry, India.
FAU - Weil, Gary J
AU  - Weil GJ
AD  - Division of Infectious Diseases, Department of Internal Medicine, Washington 
      University School of Medicine, St. Louis, Missouri.
FAU - Purushothaman, Jambulingam
AU  - Purushothaman J
AD  - ICMR-Vector Control Research Centre, Puducherry, India.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Am J Trop Med Hyg
JT  - The American journal of tropical medicine and hygiene
JID - 0370507
RN  - 0 (Anthelmintics)
RN  - 70288-86-7 (Ivermectin)
RN  - F4216019LN (Albendazole)
RN  - V867Q8X3ZD (Diethylcarbamazine)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Albendazole/administration & dosage/*adverse effects/therapeutic use
MH  - Anthelmintics/administration & dosage/*adverse effects/therapeutic use
MH  - Diethylcarbamazine/administration & dosage/*adverse effects/therapeutic use
MH  - Drug Therapy, Combination/adverse effects
MH  - Elephantiasis, Filarial/*prevention & control
MH  - Female
MH  - Humans
MH  - India/epidemiology
MH  - Ivermectin/administration & dosage/*adverse effects/therapeutic use
MH  - Male
MH  - *Mass Drug Administration
PMC - PMC6947773
EDAT- 2019/11/27 06:00
MHDA- 2020/04/22 06:00
PMCR- 2021/01/01
CRDT- 2019/11/27 06:00
PHST- 2019/11/27 06:00 [pubmed]
PHST- 2020/04/22 06:00 [medline]
PHST- 2019/11/27 06:00 [entrez]
PHST- 2021/01/01 00:00 [pmc-release]
AID - tpmd190532 [pii]
AID - 10.4269/ajtmh.19-0532 [doi]
PST - ppublish
SO  - Am J Trop Med Hyg. 2020 Jan;102(1):96-99. doi: 10.4269/ajtmh.19-0532.