PMID- 31770514
OWN - NLM
STAT- MEDLINE
DCOM- 20200508
LR  - 20210402
IS  - 1879-1891 (Electronic)
IS  - 0002-9394 (Print)
IS  - 0002-9394 (Linking)
VI  - 212
DP  - 2020 Apr
TI  - Relationship of Corneal Hysteresis and Anterior Lamina Cribrosa Displacement in 
      Glaucoma.
PG  - 134-143
LID - S0002-9394(19)30573-2 [pii]
LID - 10.1016/j.ajo.2019.11.017 [doi]
AB  - PURPOSE: To investigate the relationship between corneal hysteresis (CH) and 
      anterior lamina cribrosa surface (ALCS) displacement over time in a cohort of 
      patients with glaucoma. DESIGN: Prospective observational case series. METHODS: 
      In this study, 147 eyes from 96 glaucoma or glaucoma suspect patients were 
      followed for a mean of 3.5 years and 7.9 visits. Baseline CH measurements were 
      obtained using the Ocular Response Analyzer (ORA; Reichert Ophthalmic Instruments 
      Inc, Depew, New York, USA). The mean anterior lamina cribrosa surface depth 
      (ALCSD) and choroidal thickness were by automated segmentation of spectral-domain 
      optical coherence tomography (SD-OCT) scans. The rate of change of ALCSD was 
      calculated using linear mixed effects models. Relationship between baseline CH 
      and follow-up ALCSD rate of change was adjusted for confounding factors, 
      including age, intraocular pressure (IOP), and choroidal thickness. RESULTS: The 
      mean baseline CH was 9.4 mm Hg (95% confidence interval [CI] 9.1-9.7). Overall, 
      the ALCS was displaced posteriorly at a rate of 0.78 mum/y (95% CI -1.82, 0.26). 
      Seventeen eyes (11.5%) showed a significant posterior displacement of ALCS, 
      whereas 22 eyes (15.0%) showed a significant anterior displacement of ALCS. The 
      choroidal thickness thinned at a rate of -1.09 mum/y during the follow-up (P = 
      .001). Multivariable mixed modeling showed that choroidal thinning, lower IOP 
      change, and lower corneal hysteresis were significantly associated with posterior 
      ALCS displacement over time (P = .034, P = .037, and P = .048). Each 1 mm lower 
      CH was associated with 0.66 mum/y posterior displacement of the ALCS. CONCLUSIONS: 
      Lower corneal hysteresis was significantly associated with posterior displacement 
      of the anterior lamina cribrosa over time. These data provide additional support 
      for lower corneal hysteresis being a risk factor for glaucoma progression.
CI  - Copyright (c) 2019 Elsevier Inc. All rights reserved.
FAU - Wong, Brandon J
AU  - Wong BJ
AD  - Shiley Eye Institute, Hamilton Glaucoma Center, University of California San 
      Diego, La Jolla, California, USA; USC Roski Eye institute, Department of 
      Ophthalmology, Keck School of Medicine, University of Southern California, Los 
      Angeles, California, USA.
FAU - Moghimi, Sasan
AU  - Moghimi S
AD  - Shiley Eye Institute, Hamilton Glaucoma Center, University of California San 
      Diego, La Jolla, California, USA.
FAU - Zangwill, Linda M
AU  - Zangwill LM
AD  - Shiley Eye Institute, Hamilton Glaucoma Center, University of California San 
      Diego, La Jolla, California, USA.
FAU - Christopher, Mark
AU  - Christopher M
AD  - Shiley Eye Institute, Hamilton Glaucoma Center, University of California San 
      Diego, La Jolla, California, USA.
FAU - Belghith, Akram
AU  - Belghith A
AD  - Shiley Eye Institute, Hamilton Glaucoma Center, University of California San 
      Diego, La Jolla, California, USA.
FAU - Ekici, Eren
AU  - Ekici E
AD  - Shiley Eye Institute, Hamilton Glaucoma Center, University of California San 
      Diego, La Jolla, California, USA.
FAU - Bowd, Christopher
AU  - Bowd C
AD  - Shiley Eye Institute, Hamilton Glaucoma Center, University of California San 
      Diego, La Jolla, California, USA.
FAU - Fazio, Massimo A
AU  - Fazio MA
AD  - Department of Ophthalmology and Vision Science, School of Medicine, University of 
      Alabama at Birmingham, Birmingham, Alabama, USA.
FAU - Girkin, Christopher A
AU  - Girkin CA
AD  - Department of Ophthalmology and Vision Science, School of Medicine, University of 
      Alabama at Birmingham, Birmingham, Alabama, USA.
FAU - Weinreb, Robert N
AU  - Weinreb RN
AD  - Shiley Eye Institute, Hamilton Glaucoma Center, University of California San 
      Diego, La Jolla, California, USA. Electronic address: rweinreb@ucsd.edu.
LA  - eng
GR  - R01 EY011008/EY/NEI NIH HHS/United States
GR  - R01 EY029058/EY/NEI NIH HHS/United States
GR  - R01 EY027510/EY/NEI NIH HHS/United States
GR  - U10 EY014267/EY/NEI NIH HHS/United States
GR  - R01 EY026574/EY/NEI NIH HHS/United States
GR  - P30 EY022589/EY/NEI NIH HHS/United States
GR  - T32 EY026590/EY/NEI NIH HHS/United States
GR  - R21 EY027945/EY/NEI NIH HHS/United States
GR  - R01 EY019869/EY/NEI NIH HHS/United States
PT  - Journal Article
PT  - Observational Study
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20191123
PL  - United States
TA  - Am J Ophthalmol
JT  - American journal of ophthalmology
JID - 0370500
SB  - IM
MH  - Aged
MH  - Case-Control Studies
MH  - Cornea/*physiology
MH  - Elasticity/physiology
MH  - Female
MH  - Glaucoma/*physiopathology
MH  - Humans
MH  - Male
MH  - Prospective Studies
MH  - Risk Factors
MH  - Time Factors
PMC - PMC7113091
MID - NIHMS1545299
EDAT- 2019/11/27 06:00
MHDA- 2020/05/10 06:00
PMCR- 2021/04/01
CRDT- 2019/11/27 06:00
PHST- 2019/08/01 00:00 [received]
PHST- 2019/11/12 00:00 [revised]
PHST- 2019/11/14 00:00 [accepted]
PHST- 2019/11/27 06:00 [pubmed]
PHST- 2020/05/10 06:00 [medline]
PHST- 2019/11/27 06:00 [entrez]
PHST- 2021/04/01 00:00 [pmc-release]
AID - S0002-9394(19)30573-2 [pii]
AID - 10.1016/j.ajo.2019.11.017 [doi]
PST - ppublish
SO  - Am J Ophthalmol. 2020 Apr;212:134-143. doi: 10.1016/j.ajo.2019.11.017. Epub 2019 
      Nov 23.