PMID- 31770663
OWN - NLM
STAT- MEDLINE
DCOM- 20200203
LR  - 20200203
IS  - 1879-1506 (Electronic)
IS  - 0003-9969 (Linking)
VI  - 110
DP  - 2020 Feb
TI  - Effect of high molecular weight hyaluronic acid in treatment of osteoarthritic 
      temporomandibular joints of rats.
PG  - 104618
LID - S0003-9969(19)31017-9 [pii]
LID - 10.1016/j.archoralbio.2019.104618 [doi]
AB  - OBJECTIVE: The aim of this study was to determine the histological and 
      biochemical effects of high molecular weight hyaluronic acid on experimentally 
      induced osteoarthritic changes in male rat temporomandibular joint (TMJ). DESIGN: 
      In this in-vivo study, 36 male albino rats were divided into 3 groups; control 
      non-injected, disease and treatment group. Osteoarthritis was induced using a 
      single intra-articular injection of Complete Freund's adjuvant (CFA) (50 mul). 
      High molecular weight hyaluronic acid (HMWHA) was injected intra-articularly once 
      a week, for a total of 3 injections. TMJ tissue samples were dissected from 
      control, disease and treatment groups for biochemical analysis using ELISA test 
      to detect the levels of matrix metalloproteinase-3 (MMP-3) on day 28. 
      Histological examination was done using Hematoxylin &eosin, Mallory's trichrome 
      and Alcian blue stains. Data was analyzed using Kruskal-Wallis test followed by 
      Dunn-Sidek method, with a 5 % significance level. RESULTS: Treatment group showed 
      regaining of the normal histological features of the TMJ and decreased levels of 
      MMP-3 when compared to disease group. CONCLUSIONS: These findings may suggest 
      that HMWHA plays a role in the management of CFA-induced osteoarthritic cartilage 
      lesions.
CI  - Copyright (c) 2019 Elsevier Ltd. All rights reserved.
FAU - Tolba, Yasmine M
AU  - Tolba YM
AD  - Department of Oral Biology, Faculty of Dentistry, Alexandria University, Egypt. 
      Electronic address: yasminetolba@hotmail.com.
FAU - Omar, Samia S
AU  - Omar SS
AD  - Department of Oral Biology, Faculty of Dentistry, Alexandria University, Egypt.
FAU - Nagui, Dina A
AU  - Nagui DA
AD  - Department of Oral Biology, Faculty of Dentistry, Alexandria University, Egypt.
FAU - Nawwar, Muhammad A
AU  - Nawwar MA
AD  - Oral & Maxillofacial surgery specialist, Ministry of Health, Egypt.
LA  - eng
PT  - Journal Article
DEP - 20191116
PL  - England
TA  - Arch Oral Biol
JT  - Archives of oral biology
JID - 0116711
RN  - 9004-61-9 (Hyaluronic Acid)
SB  - IM
MH  - Animals
MH  - *Hyaluronic Acid/therapeutic use
MH  - Male
MH  - Molecular Weight
MH  - *Osteoarthritis/drug therapy
MH  - Rats
MH  - Temporomandibular Joint
MH  - *Temporomandibular Joint Disorders/drug therapy
OTO - NOTNLM
OT  - Hyaluronic acid
OT  - Matrix metalloproteinase-3
OT  - Osteoarthritis
OT  - Temporomandibular joint
EDAT- 2019/11/27 06:00
MHDA- 2020/02/06 06:00
CRDT- 2019/11/27 06:00
PHST- 2019/10/04 00:00 [received]
PHST- 2019/11/14 00:00 [revised]
PHST- 2019/11/15 00:00 [accepted]
PHST- 2019/11/27 06:00 [pubmed]
PHST- 2020/02/06 06:00 [medline]
PHST- 2019/11/27 06:00 [entrez]
AID - S0003-9969(19)31017-9 [pii]
AID - 10.1016/j.archoralbio.2019.104618 [doi]
PST - ppublish
SO  - Arch Oral Biol. 2020 Feb;110:104618. doi: 10.1016/j.archoralbio.2019.104618. Epub 
      2019 Nov 16.