PMID- 31770688
OWN - NLM
STAT- MEDLINE
DCOM- 20210617
LR  - 20210617
IS  - 1879-2472 (Electronic)
IS  - 0049-3848 (Linking)
VI  - 185
DP  - 2020 Jan
TI  - Sex-specific alteration to alpha2-antiplasmin incorporation in patients with type 2 
      diabetes.
PG  - 55-62
LID - S0049-3848(19)30443-8 [pii]
LID - 10.1016/j.thromres.2019.09.032 [doi]
AB  - BACKGROUND: Type 2 diabetes mellitus (T2DM) is associated with hypofibrinolysis 
      and increased factor XIII-mediated alpha2-antiplasmin incorporation into the fibrin 
      clot. It is unclear whether there are sex-related differences in alpha2-antiplasmin 
      incorporation in relation to impaired clot lysis in T2DM. AIM: We investigated 
      alpha2-antiplasmin incorporation into fibrin clots as a determinant of clot 
      lysability in patients of both sexes with T2DM. METHODS: In a group of 113 T2DM 
      patients, 54 (47.8%) of which were women, we investigated alpha2-antiplasmin 
      incorporation using an in-house sandwich enzyme-linked immunoassay and plasma 
      clot lysis by turbidimetry, along with fibrinogen and thrombin generation using 
      calibrated automated thrombogram and factor XIII activity. RESULTS: Female 
      patients had 15.2% greater alpha2-antiplasmin incorporation into the fibrin clot 
      (p = 0.008) and slightly higher plasma alpha2-antiplasmin concentration (p = 0.005) 
      along with 8.4% longer time to 50% lysis (Lys50(MA), p = 0.012) compared with 
      men. Female patients had enhanced thrombin generation represented by shorter lag 
      phase (p = 0.042), shorter time to peak (p = 0.033), and higher endogenous 
      thrombin potential (p = 0.003) compared with men, while factor XIII activity was 
      comparable between sexes (p = 0.085). On multivariate regression, patient sex and 
      glycated hemoglobin (HbA1c) level were the predictors of alpha2-antiplasmin 
      incorporation in the entire patient group, while alpha2-antiplasmin incorporation was 
      associated with Lys50(MA), as were fibrinogen, male sex and body-mass index. 
      CONCLUSIONS: This study suggests that a more compromised fibrinolysis in diabetic 
      women when compared with men could be in part mediated by increased 
      alpha2-antiplasmin incorporation into the fibrin.
CI  - Copyright (c) 2019 The Authors. Published by Elsevier Ltd.. All rights reserved.
FAU - Bryk, Agata Hanna
AU  - Bryk AH
AD  - Institute of Cardiology, Jagiellonian University Medical College, Krakow, Poland; 
      John Paul II Hospital, Krakow, Poland.
FAU - Siudut, Jakub
AU  - Siudut J
AD  - Institute of Cardiology, Jagiellonian University Medical College, Krakow, Poland; 
      John Paul II Hospital, Krakow, Poland.
FAU - Broniatowska, Elzbieta
AU  - Broniatowska E
AD  - Faculty of Medicine and Health Sciences, Andrzej Frycz Modrzewski Krakow 
      University, Poland.
FAU - Bagoly, Zsuzsa
AU  - Bagoly Z
AD  - Division of Clinical Laboratory Sciences, Department of Laboratory Medicine, 
      Faculty of Medicine, University of Debrecen, Debrecen, Hungary; MTA-DE 
      Cerebrovascular and Neurodegenerative Research Group, Debrecen, Hungary.
FAU - Barath, Barbara
AU  - Barath B
AD  - Division of Clinical Laboratory Sciences, Department of Laboratory Medicine, 
      Faculty of Medicine, University of Debrecen, Debrecen, Hungary.
FAU - Katona, Eva
AU  - Katona E
AD  - Division of Clinical Laboratory Sciences, Department of Laboratory Medicine, 
      Faculty of Medicine, University of Debrecen, Debrecen, Hungary.
FAU - Undas, Anetta
AU  - Undas A
AD  - Institute of Cardiology, Jagiellonian University Medical College, Krakow, Poland; 
      John Paul II Hospital, Krakow, Poland. Electronic address: mmundas@cyf-kr.edu.pl.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20191021
PL  - United States
TA  - Thromb Res
JT  - Thrombosis research
JID - 0326377
RN  - 0 (Antifibrinolytic Agents)
RN  - 0 (alpha-2-Antiplasmin)
RN  - 9001-31-4 (Fibrin)
SB  - IM
MH  - *Antifibrinolytic Agents
MH  - *Diabetes Mellitus, Type 2
MH  - Female
MH  - Fibrin
MH  - Fibrin Clot Lysis Time
MH  - Fibrinolysis
MH  - Humans
MH  - Male
MH  - alpha-2-Antiplasmin
OTO - NOTNLM
OT  - Female gender
OT  - Hypofibrinolysis
OT  - Turbidimetry
OT  - Type 2 diabetes
OT  - alpha2-antiplasmin incorporation
EDAT- 2019/11/27 06:00
MHDA- 2021/06/22 06:00
CRDT- 2019/11/27 06:00
PHST- 2019/06/05 00:00 [received]
PHST- 2019/08/12 00:00 [revised]
PHST- 2019/09/24 00:00 [accepted]
PHST- 2019/11/27 06:00 [pubmed]
PHST- 2021/06/22 06:00 [medline]
PHST- 2019/11/27 06:00 [entrez]
AID - S0049-3848(19)30443-8 [pii]
AID - 10.1016/j.thromres.2019.09.032 [doi]
PST - ppublish
SO  - Thromb Res. 2020 Jan;185:55-62. doi: 10.1016/j.thromres.2019.09.032. Epub 2019 
      Oct 21.