PMID- 31771052
OWN - NLM
STAT- MEDLINE
DCOM- 20210419
LR  - 20210419
IS  - 1875-8908 (Electronic)
IS  - 1387-2877 (Linking)
VI  - 73
IP  - 1
DP  - 2020
TI  - Impact of APOE and BDNF Val66Met Gene Polymorphisms on Cognitive Functions in 
      Patients with Amnestic Mild Cognitive Impairment.
PG  - 247-257
LID - 10.3233/JAD-190464 [doi]
AB  - Apolipoprotein (APOE) varepsilon4 is a well-known risk factor for late-onset Alzheimer's 
      disease (AD), but other AD-related gene polymorphisms might also be important, 
      such as the polymorphism within the brain-derived neurotrophic factor (BDNF) 
      gene. Carriage of BDNF Val66Met has been associated with faster cognitive decline 
      and greater hippocampal atrophy in cognitively normal elderly. Thus, we examined 
      the effects of the concurrent presence of APOE and BDNF polymorphisms on 
      cognitive functions and brain morphometry in amnestic mild cognitive impairment 
      (aMCI) patients. 107 aMCI patients (mean age = 72.2) were recruited from the 
      Czech Brain Aging Study and, based on APOE and BDNF genes polymorphisms, were 
      divided into four groups: varepsilon4-BDNFVal/Val (n = 37), varepsilon4-BDNFMet (n = 19), 
      varepsilon4+BDNFVal/Val (n = 35), and varepsilon4+BDNFMet (n = 16). All patients underwent clinical 
      examination, magnetic resonance imaging, and complex neuropsychological battery. 
      The combination of APOEvarepsilon4+ and BDNF Met was associated with significantly worse 
      memory performance in immediate and delayed recall compared to other polymorphism 
      groups. We did not observe increased atrophy in areas related to memory function 
      in the varepsilon4+BDNFMet group. Our findings suggest that carriage of varepsilon4+BDNFMet is 
      associated with more pronounced memory dysfunction, a typical feature of early 
      AD, but not with structural brain changes in aMCI patients. These findings 
      suggest that in APOEvarepsilon4/BDNF Met carriers, synaptic dysfunction affecting memory 
      may precede pronounced structural changes.
FAU - Cechova, Katerina
AU  - Cechova K
AD  - Department of Neurology, Memory Clinic, 2nd Faculty of Medicine, Charles 
      University and Motol University Hospital, Prague, Czech Republic.
AD  - International Clinical Research Center, St. Anne's University Hospital Brno, 
      Brno, Czech Republic.
FAU - Andel, Ross
AU  - Andel R
AD  - Department of Neurology, Memory Clinic, 2nd Faculty of Medicine, Charles 
      University and Motol University Hospital, Prague, Czech Republic.
AD  - International Clinical Research Center, St. Anne's University Hospital Brno, 
      Brno, Czech Republic.
AD  - School of Aging Studies, University of South Florida, Tampa, FL, USA.
FAU - Angelucci, Francesco
AU  - Angelucci F
AD  - Department of Neurology, Memory Clinic, 2nd Faculty of Medicine, Charles 
      University and Motol University Hospital, Prague, Czech Republic.
FAU - Chmatalova, Zuzana
AU  - Chmatalova Z
AD  - International Clinical Research Center, St. Anne's University Hospital Brno, 
      Brno, Czech Republic.
AD  - Department of Medical Chemistry and Clinical Biochemistry, 2nd Faculty of 
      Medicine, Charles University, Prague, Czech Republic.
FAU - Markova, Hana
AU  - Markova H
AD  - Department of Neurology, Memory Clinic, 2nd Faculty of Medicine, Charles 
      University and Motol University Hospital, Prague, Czech Republic.
AD  - International Clinical Research Center, St. Anne's University Hospital Brno, 
      Brno, Czech Republic.
FAU - Laczo, Jan
AU  - Laczo J
AD  - Department of Neurology, Memory Clinic, 2nd Faculty of Medicine, Charles 
      University and Motol University Hospital, Prague, Czech Republic.
AD  - International Clinical Research Center, St. Anne's University Hospital Brno, 
      Brno, Czech Republic.
FAU - Vyhnalek, Martin
AU  - Vyhnalek M
AD  - Department of Neurology, Memory Clinic, 2nd Faculty of Medicine, Charles 
      University and Motol University Hospital, Prague, Czech Republic.
AD  - International Clinical Research Center, St. Anne's University Hospital Brno, 
      Brno, Czech Republic.
FAU - Matoska, Vaclav
AU  - Matoska V
AD  - Department of Clinical Biochemistry, Hematology and Immunology, Homolka Hospital, 
      Prague, Czech Republic.
FAU - Kaplan, Vojtech
AU  - Kaplan V
AD  - Department of Clinical Biochemistry, Hematology and Immunology, Homolka Hospital, 
      Prague, Czech Republic.
FAU - Nedelska, Zuzana
AU  - Nedelska Z
AD  - Department of Neurology, Memory Clinic, 2nd Faculty of Medicine, Charles 
      University and Motol University Hospital, Prague, Czech Republic.
AD  - International Clinical Research Center, St. Anne's University Hospital Brno, 
      Brno, Czech Republic.
FAU - Ward, David D
AU  - Ward DD
AD  - Department of Medicine, Division of Geriatric Medicine, Dalhousie University, 
      Halifax, Nova Scotia, Canada.
AD  - Centre for Health Care of the Elderly, QEII Health Sciences Centre, Nova Scotia 
      Health Authority, Halifax, Nova Scotia, Canada.
FAU - Hort, Jakub
AU  - Hort J
AD  - Department of Neurology, Memory Clinic, 2nd Faculty of Medicine, Charles 
      University and Motol University Hospital, Prague, Czech Republic.
AD  - International Clinical Research Center, St. Anne's University Hospital Brno, 
      Brno, Czech Republic.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Netherlands
TA  - J Alzheimers Dis
JT  - Journal of Alzheimer's disease : JAD
JID - 9814863
RN  - 0 (Apolipoprotein E4)
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 7171WSG8A2 (BDNF protein, human)
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Amnesia/psychology
MH  - Apolipoprotein E4/*genetics
MH  - Atrophy
MH  - Brain/diagnostic imaging
MH  - Brain-Derived Neurotrophic Factor/*genetics
MH  - *Cognition
MH  - Cognitive Dysfunction/*genetics/psychology
MH  - Female
MH  - Heterozygote
MH  - Hippocampus/diagnostic imaging
MH  - Humans
MH  - Magnetic Resonance Imaging
MH  - Male
MH  - Memory
MH  - Mental Recall
MH  - Middle Aged
MH  - Neuropsychological Tests
MH  - Polymorphism, Genetic/genetics
OTO - NOTNLM
OT  - Alzheimer's disease
OT  - Apolipoprotein E
OT  - amnestic mild cognitive impairment
OT  - brain-derived neurotrophic factor
OT  - cognition
OT  - gene polymorphism
EDAT- 2019/11/28 06:00
MHDA- 2021/04/20 06:00
CRDT- 2019/11/28 06:00
PHST- 2019/11/28 06:00 [pubmed]
PHST- 2021/04/20 06:00 [medline]
PHST- 2019/11/28 06:00 [entrez]
AID - JAD190464 [pii]
AID - 10.3233/JAD-190464 [doi]
PST - ppublish
SO  - J Alzheimers Dis. 2020;73(1):247-257. doi: 10.3233/JAD-190464.