PMID- 31771095
OWN - NLM
STAT- MEDLINE
DCOM- 20200421
LR  - 20200421
IS  - 1420-3049 (Electronic)
IS  - 1420-3049 (Linking)
VI  - 24
IP  - 23
DP  - 2019 Nov 22
TI  - Antiviral, Antimicrobial and Antibiofilm Activity of Selenoesters and 
      Selenoanhydrides.
LID - 10.3390/molecules24234264 [doi]
LID - 4264
AB  - Selenoesters and the selenium isostere of phthalic anhydride are bioactive 
      selenium compounds with a reported promising activity in cancer, both due to 
      their cytotoxicity and capacity to reverse multidrug resistance. Herein we 
      evaluate the antiviral, the biofilm inhibitory, the antibacterial and the 
      antifungal activities of these compounds. The selenoanhydride and 7 out of the 10 
      selenoesters were especially potent antiviral agents in Vero cells infected with 
      herpes simplex virus-2 (HSV-2). In addition, the tested selenium derivatives 
      showed interesting antibiofilm activity against Staphylococcus aureus and 
      Salmonella enterica serovar Typhimurium, as well as a moderate antifungal 
      activity in resistant strains of Candida spp. They were inactive against 
      anaerobes, which may indicate that the mechanism of action of these derivatives 
      depends on the presence of oxygen. The capacity to inhibit the bacterial biofilm 
      can be of particular interest in the treatment of nosocomial infections and in 
      the coating of surfaces of prostheses. Finally, the potent antiviral activity 
      observed converts these selenium derivatives into promising antiviral agents with 
      potential medical applications.
FAU - Spengler, Gabriella
AU  - Spengler G
AD  - Department of Medical Microbiology and Immunobiology, Faculty of Medicine, 
      University of Szeged, Dom ter 10, 6720 Szeged, Hungary.
FAU - Kincses, Annamaria
AU  - Kincses A
AD  - Department of Medical Microbiology and Immunobiology, Faculty of Medicine, 
      University of Szeged, Dom ter 10, 6720 Szeged, Hungary.
FAU - Mosolygo, Timea
AU  - Mosolygo T
AD  - Department of Medical Microbiology and Immunobiology, Faculty of Medicine, 
      University of Szeged, Dom ter 10, 6720 Szeged, Hungary.
FAU - Marc, Malgorzata Anna
AU  - Marc MA
AD  - Department of Medical Microbiology and Immunobiology, Faculty of Medicine, 
      University of Szeged, Dom ter 10, 6720 Szeged, Hungary.
FAU - Nove, Marta
AU  - Nove M
AD  - Department of Medical Microbiology and Immunobiology, Faculty of Medicine, 
      University of Szeged, Dom ter 10, 6720 Szeged, Hungary.
FAU - Gajdacs, Mario
AU  - Gajdacs M
AD  - Department of Pharmacodynamics and Biopharmacy, Faculty of Pharmacy, University 
      of Szeged, Eotvos utca 6, 6720 Szeged, Hungary.
FAU - Sanmartin, Carmen
AU  - Sanmartin C
AD  - Department of Pharmaceutical Technology and Chemistry, School of Pharmacy and 
      Nutrition, University of Navarra, Irunlarrea 1, 31008 Pamplona, Spain.
AD  - Instituto de Investigacion Sanitaria de Navarra (IdiSNA), Irunlarrea 3, 31008 
      Pamplona, Spain.
FAU - McNeil, Helen E
AU  - McNeil HE
AD  - Institute of Microbiology and Infection, College of Medical and Dental Sciences, 
      University of Birmingham, Birmingham B15 2TT, UK.
FAU - Blair, Jessica M A
AU  - Blair JMA
AD  - Institute of Microbiology and Infection, College of Medical and Dental Sciences, 
      University of Birmingham, Birmingham B15 2TT, UK.
FAU - Dominguez-Alvarez, Enrique
AU  - Dominguez-Alvarez E
AD  - Instituto de Quimica Organica General (IQOG-CSIC), Consejo Superior de 
      Investigaciones Cientificas, Juan de la Cierva 3, 28006 Madrid, Spain.
LA  - eng
GR  - 201780I027/Consejo Superior de Investigaciones Cientificas/
GR  - Janos Bolyai Research Scholarship/Magyar Tudomanyos Akademia/
GR  - TAMOP 4.2.4. A/2-11-1-2012-000/State of Hungary/
GR  - New National Excellence Program (UNKP-18-3)/Ministry of Human Capacities of 
      Hungary/
PT  - Journal Article
DEP - 20191122
PL  - Switzerland
TA  - Molecules
JT  - Molecules (Basel, Switzerland)
JID - 100964009
RN  - 0 (Anti-Bacterial Agents)
RN  - 0 (Antifungal Agents)
RN  - 0 (Antiviral Agents)
RN  - 0 (Phthalic Anhydrides)
RN  - 0 (Selenium Compounds)
SB  - IM
MH  - Animals
MH  - Anti-Bacterial Agents/*chemical synthesis/chemistry/pharmacology
MH  - Antifungal Agents/*chemical synthesis/chemistry/pharmacology
MH  - Antiviral Agents/*chemical synthesis/chemistry/pharmacology
MH  - Biofilms/drug effects
MH  - Candida/drug effects
MH  - Chlorocebus aethiops
MH  - Herpesvirus 2, Human/drug effects
MH  - Molecular Structure
MH  - Phthalic Anhydrides/*chemistry
MH  - Salmonella typhimurium/drug effects/physiology
MH  - Selenium Compounds/*chemical synthesis/chemistry/pharmacology
MH  - Staphylococcus aureus/drug effects/physiology
MH  - Vero Cells
PMC - PMC6930503
OTO - NOTNLM
OT  - Candida spp
OT  - HSV-2
OT  - Salmonella Typhimurium
OT  - Staphylococcus aureus
OT  - antibacterials
OT  - antifungals
OT  - antivirals
OT  - biofilm inhibitors
OT  - selenoanhydrides
OT  - selenoesters
COIS- The authors declare no conflicts of interest, and the funders had no role in the 
      design of the study; in the collection, analyses, or interpretation of data; in 
      the writing of the manuscript, or in the decision to publish the results.
EDAT- 2019/11/28 06:00
MHDA- 2020/04/22 06:00
PMCR- 2019/11/22
CRDT- 2019/11/28 06:00
PHST- 2019/10/28 00:00 [received]
PHST- 2019/11/15 00:00 [revised]
PHST- 2019/11/18 00:00 [accepted]
PHST- 2019/11/28 06:00 [entrez]
PHST- 2019/11/28 06:00 [pubmed]
PHST- 2020/04/22 06:00 [medline]
PHST- 2019/11/22 00:00 [pmc-release]
AID - molecules24234264 [pii]
AID - molecules-24-04264 [pii]
AID - 10.3390/molecules24234264 [doi]
PST - epublish
SO  - Molecules. 2019 Nov 22;24(23):4264. doi: 10.3390/molecules24234264.