PMID- 31771683
OWN - NLM
STAT- MEDLINE
DCOM- 20201021
LR  - 20201021
IS  - 1475-2662 (Electronic)
IS  - 0007-1145 (Linking)
VI  - 123
IP  - 5
DP  - 2020 Mar 14
TI  - The effects of myo-inositol and probiotic supplementation in a high-fat-fed 
      preclinical model of glucose intolerance in pregnancy.
PG  - 516-528
LID - 10.1017/S0007114519003039 [doi]
AB  - Glucose intolerance during pregnancy - a major driver of gestational diabetes 
      mellitus (GDM) - has significant short- and long-term health consequences for 
      both the mother and child. As GDM prevalence continues to escalate, there is 
      growing need for preventative strategies. There is limited but suggestive 
      evidence that myo-inositol (MI) and probiotics (PB) could improve glucose 
      tolerance during pregnancy. The present study tested the hypothesis that MI 
      and/or PB supplementation would reduce the risk of glucose intolerance during 
      pregnancy. Female C57BL/6 mice were randomised to receive either no treatment, 
      MI, PB (Lactobacillus rhamnosus and Bifidobacterium lactis) or both (MIPB) for 5 
      weeks. They were then provided with a high-fat diet for 1 week before mating 
      commenced and throughout mating/gestation, while remaining on their respective 
      treatments. An oral glucose tolerance test occurred at gestational day (GD) 16.5 
      and tissue collection at GD 18.5. Neither MI nor PB, separately or combined, 
      improved glucose tolerance. However, MI and PB both independently increased 
      adipose tissue expression of Ir, Irs1, Akt2 and Pck1, and PB also increased 
      Ppargamma. MI was associated with reduced gestational weight gain, whilst PB was 
      associated with increased maternal fasting glucose, total cholesterol and 
      pancreas weight. These results suggest that MI and PB may improve insulin 
      intracellular signalling in adipose tissue but this did not translate to 
      meaningful differences in glucose tolerance. The absence of fasting 
      hyperglycaemia or insulin resistance suggests this is a very mild model of GDM, 
      which may have affected our ability to assess the impact of these nutrients.
FAU - Plows, J F
AU  - Plows JF
AUID- ORCID: 0000-0002-1421-3387
AD  - Liggins Institute, University of Auckland, Grafton, Auckland1021, New Zealand.
AD  - Children's Hospital Los Angeles, The Saban Research Institute, Los Angeles, 
      CA90027, USA.
FAU - Ramos Nieves, J M
AU  - Ramos Nieves JM
AD  - Nestle Research, Vers-chez-les-Blanc, Lausanne 261000, Switzerland.
FAU - Budin, F
AU  - Budin F
AD  - Nestle Research, Vers-chez-les-Blanc, Lausanne 261000, Switzerland.
FAU - Mace, K
AU  - Mace K
AD  - Nestle Research, Vers-chez-les-Blanc, Lausanne 261000, Switzerland.
FAU - Reynolds, C M
AU  - Reynolds CM
AD  - Liggins Institute, University of Auckland, Grafton, Auckland1021, New Zealand.
FAU - Vickers, M H
AU  - Vickers MH
AD  - Liggins Institute, University of Auckland, Grafton, Auckland1021, New Zealand.
FAU - Silva-Zolezzi, I
AU  - Silva-Zolezzi I
AD  - Nestle Research, Singapore 138567, Singapore.
FAU - Baker, P N
AU  - Baker PN
AD  - Liggins Institute, University of Auckland, Grafton, Auckland1021, New Zealand.
AD  - University of Leicester, LeicesterLE1 7RH, UK.
FAU - Stanley, J L
AU  - Stanley JL
AD  - Liggins Institute, University of Auckland, Grafton, Auckland1021, New Zealand.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20191127
PL  - England
TA  - Br J Nutr
JT  - The British journal of nutrition
JID - 0372547
RN  - 0 (Blood Glucose)
RN  - 0 (Insulin)
RN  - 4L6452S749 (Inositol)
SB  - IM
MH  - Adipose Tissue/metabolism
MH  - Animals
MH  - Blood Glucose/metabolism
MH  - Diabetes, Gestational/etiology/prevention & control
MH  - Diet, High-Fat
MH  - *Dietary Supplements
MH  - Disease Models, Animal
MH  - Female
MH  - Glucose Intolerance/blood/*therapy
MH  - Glucose Tolerance Test
MH  - Inositol/*administration & dosage
MH  - Insulin/blood
MH  - Insulin Resistance
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Pregnancy
MH  - Pregnancy Complications/blood/*therapy
MH  - Probiotics/*therapeutic use
OTO - NOTNLM
OT  - Diabetes
OT  - Gestational diabetes
OT  - Glucose intolerance
OT  - High-fat diet
OT  - Inositol
OT  - Myo-inositol
OT  - Probiotics
EDAT- 2019/11/28 06:00
MHDA- 2020/10/22 06:00
CRDT- 2019/11/28 06:00
PHST- 2019/11/28 06:00 [pubmed]
PHST- 2020/10/22 06:00 [medline]
PHST- 2019/11/28 06:00 [entrez]
AID - S0007114519003039 [pii]
AID - 10.1017/S0007114519003039 [doi]
PST - ppublish
SO  - Br J Nutr. 2020 Mar 14;123(5):516-528. doi: 10.1017/S0007114519003039. Epub 2019 
      Nov 27.