PMID- 31772329
OWN - NLM
STAT- MEDLINE
DCOM- 20201124
LR  - 20220418
IS  - 1476-5594 (Electronic)
IS  - 0950-9232 (Linking)
VI  - 39
IP  - 9
DP  - 2020 Feb
TI  - Bone marrow dendritic cells support the survival of chronic lymphocytic leukemia 
      cells in a CD84 dependent manner.
PG  - 1997-2008
LID - 10.1038/s41388-019-1121-y [doi]
AB  - Chronic lymphocytic leukemia (CLL) is a malignancy of mature B lymphocytes. The 
      microenvironment of the CLL cells is a vital element in the regulation of the 
      survival of these malignant cells. CLL cell longevity is dependent on external 
      signals, originating from cells in their microenvironment including secreted and 
      surface-bound factors. Dendritic cells (DCs) play an important part in tumor 
      microenvironment, but their role in the CLL bone marrow (BM) niche has not been 
      studied. We show here that CLL cells induce accumulation of bone marrow dendritic 
      cells (BMDCs). Depletion of this population attenuates disease expansion. Our 
      results show that the support of the microenvironment is partly dependent on 
      CD84, a cell surface molecule belonging to the Signaling Lymphocyte Activating 
      Molecule (SLAM) family of immunoreceptors. Our results suggest a novel 
      therapeutic strategy whereby eliminating BMDCs or blocking the CD84 expressed on 
      these cells may reduce the tumor load.
FAU - Barak, Avital F
AU  - Barak AF
AD  - Department of Immunology, Weizmann Institute of Science, Rehovot, 76100, Israel.
FAU - Lewinsky, Hadas
AU  - Lewinsky H
AD  - Department of Immunology, Weizmann Institute of Science, Rehovot, 76100, Israel.
FAU - Perpinial, Michal
AU  - Perpinial M
AD  - Department of Immunology, Weizmann Institute of Science, Rehovot, 76100, Israel.
FAU - Huber, Victoria
AU  - Huber V
AD  - Department of Immunology, Weizmann Institute of Science, Rehovot, 76100, Israel.
FAU - Radomir, Lihi
AU  - Radomir L
AD  - Department of Immunology, Weizmann Institute of Science, Rehovot, 76100, Israel.
FAU - Kramer, Mattias P
AU  - Kramer MP
AD  - Department of Immunology, Weizmann Institute of Science, Rehovot, 76100, Israel.
FAU - Sever, Lital
AU  - Sever L
AD  - Department of Immunology, Weizmann Institute of Science, Rehovot, 76100, Israel.
FAU - Wolf, Yochai
AU  - Wolf Y
AD  - Department of Immunology, Weizmann Institute of Science, Rehovot, 76100, Israel.
FAU - Shapiro, Mika
AU  - Shapiro M
AD  - Department of Hematology, Tel-Aviv Sourasky Medical Center, Sackler Faculty of 
      Medicine, Tel-Aviv University, Tel-Aviv, Israel.
FAU - Herishanu, Yair
AU  - Herishanu Y
AD  - Department of Hematology, Tel-Aviv Sourasky Medical Center, Sackler Faculty of 
      Medicine, Tel-Aviv University, Tel-Aviv, Israel.
FAU - Jung, Steffen
AU  - Jung S
AD  - Department of Immunology, Weizmann Institute of Science, Rehovot, 76100, Israel.
FAU - Becker-Herman, Shirly
AU  - Becker-Herman S
AD  - Department of Immunology, Weizmann Institute of Science, Rehovot, 76100, Israel.
FAU - Shachar, Idit
AU  - Shachar I
AD  - Department of Immunology, Weizmann Institute of Science, Rehovot, 76100, Israel. 
      idit.shachar@weizmann.ac.il.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20191126
PL  - England
TA  - Oncogene
JT  - Oncogene
JID - 8711562
RN  - 0 (CD84 protein, human)
RN  - 0 (Signaling Lymphocytic Activation Molecule Family)
SB  - IM
MH  - Animals
MH  - Apoptosis
MH  - Bone Marrow/immunology/metabolism/*pathology
MH  - Cell Proliferation
MH  - Dendritic Cells/immunology/metabolism/*pathology
MH  - Female
MH  - Humans
MH  - Leukemia, Lymphocytic, Chronic, B-Cell/immunology/metabolism/*pathology
MH  - Mice
MH  - Mice, Transgenic
MH  - Prognosis
MH  - Signaling Lymphocytic Activation Molecule Family/*metabolism
MH  - Tumor Cells, Cultured
MH  - Tumor Microenvironment/*immunology
EDAT- 2019/11/28 06:00
MHDA- 2020/11/25 06:00
CRDT- 2019/11/28 06:00
PHST- 2019/04/18 00:00 [received]
PHST- 2019/11/13 00:00 [accepted]
PHST- 2019/11/11 00:00 [revised]
PHST- 2019/11/28 06:00 [pubmed]
PHST- 2020/11/25 06:00 [medline]
PHST- 2019/11/28 06:00 [entrez]
AID - 10.1038/s41388-019-1121-y [pii]
AID - 10.1038/s41388-019-1121-y [doi]
PST - ppublish
SO  - Oncogene. 2020 Feb;39(9):1997-2008. doi: 10.1038/s41388-019-1121-y. Epub 2019 Nov 
      26.