PMID- 31772530
OWN - NLM
STAT- MEDLINE
DCOM- 20200304
LR  - 20220411
IS  - 1540-8183 (Electronic)
IS  - 0896-4327 (Print)
IS  - 0896-4327 (Linking)
VI  - 2019
DP  - 2019
TI  - Life beyond 5 Years after TAVI: Patients' Perceived Health Status and Long-Term 
      Outcome after Transcatheter Aortic Valve Implantation.
PG  - 4292987
LID - 10.1155/2019/4292987 [doi]
LID - 4292987
AB  - BACKGROUND: Transcatheter aortic valve implantation (TAVI) is currently 
      recommended for patients with severe aortic stenosis at intermediate or high 
      surgical risk. The decision process during TAVI evaluation includes a thorough 
      benefit-risk assessment, and knowledge about long-term benefits and outcomes may 
      improve patients' expectation management. OBJECTIVE: To evaluate patients' 
      perceived health status and self-reported long-term outcome more than 5 years 
      after TAVI. METHODS AND RESULTS: Demographic and procedure data were obtained 
      from all patients treated with TAVI at our institution from 2006 to 2012. A 
      cross-sectional survey was conducted on the patients alive, measuring health 
      status, including the EQ-5D-5L questionnaire, and clinical outcomes. 103 patients 
      (22.8%) were alive at a median follow-up period of 7 years (5.4-9.8). 99 (96%) of 
      the 103 patients were included in the final analysis. The mean age at follow-up 
      was 86.5 years +/- 8.0 years, and 56.6% were female. Almost all patients (93.9%) 
      described an improvement of their quality of life after receiving TAVI. At late 
      follow-up, the mean utility index and EQ-VAS score were 0.80 +/- 0.20 and 
      58.49 +/- 11.49, respectively. Mobility was found to be the most frequently 
      reported limitation (85.4%), while anxiety/depression was the least frequently 
      reported limitation (19.8%). With respect to functional class, 64.7% were in New 
      York Heart Association (NYHA) class III or IV, compared to 67.0% prior to TAVI 
      (p=0.51). Self-reported long-term outcomes revealed mainly low long-term 
      complication rates. 74 total hospitalizations were reported after TAVI, and among 
      those 43% for cardiovascular reasons. Within cardiovascular rehospitalizations, 
      new pacemaker implantations were the most frequently reported (18.9%), followed 
      by cardiac decompensation and coronary heart disease (15.6%). CONCLUSION: The 
      majority of the patients described an improvement of health status after TAVI. 
      More than five years after TAVI, the patients' perceived health status was 
      satisfactory, and the incidence of clinical events and hospitalizations was very 
      low.
CI  - Copyright (c) 2019 Marie-Isabel K. Murray et al.
FAU - Murray, Marie-Isabel K
AU  - Murray MK
AUID- ORCID: 0000-0003-1872-2899
AD  - Department of Cardiology, University Hospital Frankfurt, Frankfurt am Main, 
      Germany.
FAU - Hofmann, Eileen
AU  - Hofmann E
AD  - Department of Cardiology, University Hospital Frankfurt, Frankfurt am Main, 
      Germany.
FAU - De Rosa, Roberta
AU  - De Rosa R
AD  - Department of Cardiology, University Hospital Frankfurt, Frankfurt am Main, 
      Germany.
FAU - Mas-Peiro, Silvia
AU  - Mas-Peiro S
AD  - Department of Cardiology, University Hospital Frankfurt, Frankfurt am Main, 
      Germany.
FAU - Seppelt, Philipp
AU  - Seppelt P
AUID- ORCID: 0000-0003-4743-6920
AD  - Department of Cardiology, University Hospital Frankfurt, Frankfurt am Main, 
      Germany.
FAU - Walther, Thomas
AU  - Walther T
AD  - Department of Cardiac Surgery, University Hospital Frankfurt, Frankfurt am Main, 
      Germany.
FAU - Zeiher, Andreas M
AU  - Zeiher AM
AD  - Department of Cardiology, University Hospital Frankfurt, Frankfurt am Main, 
      Germany.
FAU - Fichtlscherer, Stephan
AU  - Fichtlscherer S
AD  - Department of Cardiology, University Hospital Frankfurt, Frankfurt am Main, 
      Germany.
FAU - Vasa-Nicotera, Mariuca
AU  - Vasa-Nicotera M
AD  - Department of Cardiology, University Hospital Frankfurt, Frankfurt am Main, 
      Germany.
LA  - eng
PT  - Journal Article
DEP - 20191001
PL  - United States
TA  - J Interv Cardiol
JT  - Journal of interventional cardiology
JID - 8907826
SB  - IM
MH  - Aged, 80 and over
MH  - Aortic Valve Stenosis/surgery
MH  - Cross-Sectional Studies
MH  - Female
MH  - Follow-Up Studies
MH  - Germany/epidemiology
MH  - *Health Status
MH  - Hospitalization/statistics & numerical data
MH  - Humans
MH  - Male
MH  - Mobility Limitation
MH  - *Quality of Life
MH  - *Transcatheter Aortic Valve Replacement
PMC - PMC6794985
COIS- Mariuca Vasa-Nicotera is proctor for Abbott, Medtronic, and Boston Scientific; 
      Stephan Fichtlscherer and Thomas Walther are proctors and report consultancy 
      activities for Abbott and Edwards Lifesciences. All other authors have no 
      conflicts of interest related to the subject of the article.
EDAT- 2019/11/28 06:00
MHDA- 2020/03/05 06:00
PMCR- 2019/10/01
CRDT- 2019/11/28 06:00
PHST- 2019/06/20 00:00 [received]
PHST- 2019/08/09 00:00 [revised]
PHST- 2019/08/26 00:00 [accepted]
PHST- 2019/11/28 06:00 [entrez]
PHST- 2019/11/28 06:00 [pubmed]
PHST- 2020/03/05 06:00 [medline]
PHST- 2019/10/01 00:00 [pmc-release]
AID - 10.1155/2019/4292987 [doi]
PST - epublish
SO  - J Interv Cardiol. 2019 Oct 1;2019:4292987. doi: 10.1155/2019/4292987. eCollection 
      2019.