PMID- 31772534
OWN - NLM
STAT- MEDLINE
DCOM- 20200228
LR  - 20220411
IS  - 1540-8183 (Electronic)
IS  - 0896-4327 (Print)
IS  - 0896-4327 (Linking)
VI  - 2019
DP  - 2019
TI  - Impact of Late Ventricular Arrhythmias on Cardiac Mortality in Patients with 
      Acute Myocardial Infarction.
PG  - 5345178
LID - 10.1155/2019/5345178 [doi]
LID - 5345178
AB  - OBJECTIVES: This study investigated the relationship between the timing of 
      ventricular tachycardia or ventricular fibrillation (VT or VF) and prognosis in 
      patients undergoing primary percutaneous coronary intervention (PCI) for acute 
      myocardial infarction (AMI). BACKGROUND: It is unknown whether the timing of 
      VT/VF occurrence affects the prognosis of patients with AMI. METHODS: From 
      January 2004 to December 2014, 1004 patients with AMI underwent primary PCI. Of 
      these patients, 888 did not have VT/VF (non-VT/VF group) and 116 had sustained 
      VT/VF during prehospitalization or hospitalization. Patients with VT/VF were 
      divided into two groups: early VT/VF (VT/VF occurrence before and within 2 days 
      of admission, 92 patients) and late VT/VF (VT/VF occurrence >2 days after 
      admission; 24 patients) groups. RESULTS: The frequency of VT/VF occurrence was 
      high between the day of admission and the 2nd day and between days 6 and 10 of 
      hospitalization. The late VT/VF group had a significantly longer onset-to-balloon 
      time, lower ejection fraction, poorer renal function, and higher creatine 
      phosphokinase (CK)-MB level on admission (p< 0.001). They also had a lower 30-day 
      cardiac survival rate than the early VT/VF and non-VT/VF groups (42% vs. 76% vs. 
      96%, p < 0.001). Moreover, independent predictors of in-hospital cardiac 
      mortality among patients with AMI who had sustained VT/VF were higher peak CK-MB 
      [Odds ratio (OR: 1.001, 95%confidence interval (CI): 1.000-1.002, p= 0.03)], 
      higher Killip class (OR: 1.484, 95%CI 1.017-2.165, p= 0.04), and late VT/VF (OR: 
      3.436, 95%CI 1.115-10.59, p= 0.03). CONCLUSIONS: The timing of VT/VF occurrences 
      had a bimodal peak. Although late VT/VF occurrence after primary PCI was less 
      frequent than early VT/VF occurrence, patients with late VT/VF had a very poor 
      prognosis.
CI  - Copyright (c) 2019 Takuma Takada et al.
FAU - Takada, Takuma
AU  - Takada T
AUID- ORCID: 0000-0002-9172-0163
AD  - Department of Cardiology and Catheterization Laboratories, Shonan Kamakura 
      General Hospital, Okamoto 1370-1, Kamakura City 247-8533, Japan.
FAU - Shishido, Koki
AU  - Shishido K
AUID- ORCID: 0000-0002-3100-6216
AD  - Department of Cardiology and Catheterization Laboratories, Shonan Kamakura 
      General Hospital, Okamoto 1370-1, Kamakura City 247-8533, Japan.
FAU - Hayashi, Takahiro
AU  - Hayashi T
AD  - Department of Cardiology and Catheterization Laboratories, Shonan Kamakura 
      General Hospital, Okamoto 1370-1, Kamakura City 247-8533, Japan.
FAU - Yokota, Shohei
AU  - Yokota S
AD  - Department of Cardiology and Catheterization Laboratories, Shonan Kamakura 
      General Hospital, Okamoto 1370-1, Kamakura City 247-8533, Japan.
FAU - Miyashita, Hirokazu
AU  - Miyashita H
AD  - Department of Cardiology and Catheterization Laboratories, Shonan Kamakura 
      General Hospital, Okamoto 1370-1, Kamakura City 247-8533, Japan.
FAU - Yokoyama, Hiroaki
AU  - Yokoyama H
AD  - Department of Cardiology and Catheterization Laboratories, Shonan Kamakura 
      General Hospital, Okamoto 1370-1, Kamakura City 247-8533, Japan.
FAU - Nishimoto, Takashi
AU  - Nishimoto T
AD  - Department of Cardiology and Catheterization Laboratories, Shonan Kamakura 
      General Hospital, Okamoto 1370-1, Kamakura City 247-8533, Japan.
FAU - Ochiai, Tomoki
AU  - Ochiai T
AD  - Department of Cardiology and Catheterization Laboratories, Shonan Kamakura 
      General Hospital, Okamoto 1370-1, Kamakura City 247-8533, Japan.
FAU - Moriyama, Noriaki
AU  - Moriyama N
AD  - Department of Cardiology and Catheterization Laboratories, Shonan Kamakura 
      General Hospital, Okamoto 1370-1, Kamakura City 247-8533, Japan.
FAU - Tobita, Kazuki
AU  - Tobita K
AD  - Department of Cardiology and Catheterization Laboratories, Shonan Kamakura 
      General Hospital, Okamoto 1370-1, Kamakura City 247-8533, Japan.
FAU - Mizuno, Shingo
AU  - Mizuno S
AD  - Department of Cardiology and Catheterization Laboratories, Shonan Kamakura 
      General Hospital, Okamoto 1370-1, Kamakura City 247-8533, Japan.
FAU - Yamanaka, Futoshi
AU  - Yamanaka F
AD  - Department of Cardiology and Catheterization Laboratories, Shonan Kamakura 
      General Hospital, Okamoto 1370-1, Kamakura City 247-8533, Japan.
FAU - Murakami, Masato
AU  - Murakami M
AD  - Department of Cardiology and Catheterization Laboratories, Shonan Kamakura 
      General Hospital, Okamoto 1370-1, Kamakura City 247-8533, Japan.
FAU - Tanaka, Yutaka
AU  - Tanaka Y
AD  - Department of Cardiology and Catheterization Laboratories, Shonan Kamakura 
      General Hospital, Okamoto 1370-1, Kamakura City 247-8533, Japan.
FAU - Takahashi, Saeko
AU  - Takahashi S
AD  - Department of Cardiology and Catheterization Laboratories, Shonan Kamakura 
      General Hospital, Okamoto 1370-1, Kamakura City 247-8533, Japan.
FAU - Saito, Shigeru
AU  - Saito S
AD  - Department of Cardiology and Catheterization Laboratories, Shonan Kamakura 
      General Hospital, Okamoto 1370-1, Kamakura City 247-8533, Japan.
LA  - eng
PT  - Journal Article
DEP - 20190708
PL  - United States
TA  - J Interv Cardiol
JT  - Journal of interventional cardiology
JID - 8907826
SB  - IM
MH  - Aged
MH  - Female
MH  - Humans
MH  - Incidence
MH  - Japan
MH  - Male
MH  - Middle Aged
MH  - *Myocardial Infarction/mortality/surgery
MH  - Outcome and Process Assessment, Health Care
MH  - *Percutaneous Coronary Intervention/adverse effects/methods
MH  - *Postoperative Complications/diagnosis/mortality
MH  - Prognosis
MH  - Risk Factors
MH  - *Tachycardia, Ventricular/diagnosis/etiology/mortality
MH  - Time Factors
MH  - *Ventricular Fibrillation/diagnosis/etiology/mortality
PMC - PMC6739782
COIS- The authors declare that there are no conflicts of interest.
EDAT- 2019/11/28 06:00
MHDA- 2020/02/29 06:00
PMCR- 2019/07/08
CRDT- 2019/11/28 06:00
PHST- 2019/03/27 00:00 [received]
PHST- 2019/06/08 00:00 [revised]
PHST- 2019/06/12 00:00 [accepted]
PHST- 2019/11/28 06:00 [entrez]
PHST- 2019/11/28 06:00 [pubmed]
PHST- 2020/02/29 06:00 [medline]
PHST- 2019/07/08 00:00 [pmc-release]
AID - 10.1155/2019/5345178 [doi]
PST - epublish
SO  - J Interv Cardiol. 2019 Jul 8;2019:5345178. doi: 10.1155/2019/5345178. eCollection 
      2019.