PMID- 31772629
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20201001
IS  - 1792-0981 (Print)
IS  - 1792-1015 (Electronic)
IS  - 1792-0981 (Linking)
VI  - 18
IP  - 6
DP  - 2019 Dec
TI  - Bioinformatics analysis of hepatic gene expression profiles in type 2 diabetes 
      mellitus.
PG  - 4303-4312
LID - 10.3892/etm.2019.8092 [doi]
AB  - Type 2 diabetes mellitus (T2DM) is characterized by hyperglycemia. The liver has 
      a critical role in regulating glucose homeostasis. The present study aimed to 
      analyze hepatic gene expression profiles and to identify the key genes and 
      pathways involved in T2DM. Gene expression profiles of 10 patients with T2DM and 
      7 subjects with normal glucose tolerance were downloaded from the Gene Expression 
      Omnibus database. Subsequently, differentially expressed genes (DEGs) were 
      identified and functional enrichment analysis was performed. In addition, a 
      protein-protein interaction network was built and hub genes were identified. In 
      total, 1,320 DEGs were identified, including 698 up- and 622 downregulated genes, 
      and these were mainly enriched in positive regulation of transcription from RNA 
      polymerase II promoter, cell adhesion, inflammatory response, positive regulation 
      of apoptotic process, signal transduction and the Tolllike receptor signaling 
      pathway. A total of 8 hub genes (G-protein subunit gamma transducin 2, 
      ubiquitinconjugating enzyme E2 D1, glutamate metabotropic receptor 1, G-protein 
      signaling modulator 1, C-X-C motif chemokine ligand 9, neurotensin, purinergic 
      receptor P2Y1 and ring finger protein 41) were screened from the network. The 
      present study may contribute to the elucidation of the hepatic pathology of T2DM.
CI  - Copyright: (c) Chen et al.
FAU - Chen, Zhe
AU  - Chen Z
AD  - Institute of Clinical Pharmacology, Guangzhou University of Chinese Medicine, 
      Guangzhou, Guangdong 510405, P.R. China.
FAU - Yuan, Weiqu
AU  - Yuan W
AD  - The Fourth Clinical Medical School, Guangzhou University of Chinese Medicine, 
      Shenzhen, Guangdong 518033, P.R. China.
FAU - Liu, Tao
AU  - Liu T
AD  - School of Traditional Chinese Medicine, Guangdong Pharmaceutical University, 
      Guangzhou, Guangdong 510006, P.R. China.
FAU - Huang, Danping
AU  - Huang D
AD  - The Fourth Clinical Medical School, Guangzhou University of Chinese Medicine, 
      Shenzhen, Guangdong 518033, P.R. China.
FAU - Xiang, Lei
AU  - Xiang L
AD  - Department of Integrative Chinese and Western Medicine, The First Affiliated 
      Hospital of Guangdong Pharmaceutical University, Guangzhou, Guangdong 510080, 
      P.R. China.
LA  - eng
PT  - Journal Article
DEP - 20191010
PL  - Greece
TA  - Exp Ther Med
JT  - Experimental and therapeutic medicine
JID - 101531947
PMC - PMC6861877
OTO - NOTNLM
OT  - bioinformatics analysis
OT  - differentially expressed genes
OT  - hepatic gene expression profiles
OT  - protein-protein interaction network
OT  - type 2 diabetes mellitus
EDAT- 2019/11/28 06:00
MHDA- 2019/11/28 06:01
PMCR- 2019/10/10
CRDT- 2019/11/28 06:00
PHST- 2019/03/25 00:00 [received]
PHST- 2019/09/19 00:00 [accepted]
PHST- 2019/11/28 06:00 [entrez]
PHST- 2019/11/28 06:00 [pubmed]
PHST- 2019/11/28 06:01 [medline]
PHST- 2019/10/10 00:00 [pmc-release]
AID - ETM-0-0-8092 [pii]
AID - 10.3892/etm.2019.8092 [doi]
PST - ppublish
SO  - Exp Ther Med. 2019 Dec;18(6):4303-4312. doi: 10.3892/etm.2019.8092. Epub 2019 Oct 
      10.