PMID- 31773393
OWN - NLM
STAT- MEDLINE
DCOM- 20210210
LR  - 20210210
IS  - 1437-160X (Electronic)
IS  - 0172-8172 (Linking)
VI  - 40
IP  - 3
DP  - 2020 Mar
TI  - Tobacco smoking is an independent factor associated with retinal damage in 
      systemic lupus erythematosus: a cross-sectional and retrospective study.
PG  - 367-374
LID - 10.1007/s00296-019-04473-8 [doi]
AB  - To analyze the influence of tobacco smoking on systemic lupus erythematosus (SLE) 
      clinical features and damage. Cross-sectional and retrospective, case-control 
      study comparing SLE patients with and without tobacco exposure. Cumulative 
      clinical data and comorbidities were collected, and severity (Katz index) and 
      damage (SLICC/ACR damage index) (SDI) indices were calculated. Pack-years (PY) 
      was used to estimate lifetime tobacco exposure. A logistic regression was carried 
      out to explore the impact of tobacco use on retinal damage. 216 patients were 
      included. The mean age was 49 years (+/- 12.7), 93% were females, and median 
      disease duration was 17 years [interquartile range (IQR):9-25]. Fifty-three 
      percent of patients were smokers at some point. The median PY was 13 (IQR: 
      6-20.5). Only 54.8% of active smokers recalled having been informed of the 
      negative effects of smoking, versus 83.3% of never smokers (< 0.001). In a 
      bivariant analysis, an association between tobacco use at any time and discoid 
      lupus [OR: 3.5(95%CI 1.5-8.9); p = 0.002] photosensitivity [OR: 2.06(95%CI 
      1.16-3.7); p = 0.01] and peripheral arteriopathy (p = 0.007) was found. 
      Considering SDI item by item, a significant association with retinal damage, 
      adjusted for age [OR: 1.03(95%CI 1-1.07); p = 0.04], was found. Using PYs, an 
      association was found with discoid lupus (p = 0.01), photosensitivity (p = 0.03) 
      and peripheral arteriopathy (p = 0.01), global SDI > 0 (p = 0.002) and retinal 
      damage (p = 0.02). In a multivariate analysis exploring factors associated with 
      retinal damage, any previous smoking history and SDI remained associated with 
      retinal damage. Tobacco smoking is associated with cutaneous manifestations and 
      damage and is an independent predictor of retinal damage in SLE patients.
FAU - Rua-Figueroa, Inigo
AU  - Rua-Figueroa I
AUID- ORCID: 0000-0002-7894-1690
AD  - Rheumatology Service, Hospital Universitario de Gran Canaria Doctor Negrin, Las 
      Palmas, GC, Spain. iruafer@gobiernodecanarias.org.
FAU - Erausquin, Celia
AU  - Erausquin C
AD  - Rheumatology Service, Hospital Universitario de Gran Canaria Doctor Negrin, Las 
      Palmas, GC, Spain.
FAU - Rua-Figueroa, Celia
AU  - Rua-Figueroa C
AD  - Medical School, University of Las Palmas de Gran Canaria, Las Palmas, GC, Spain.
FAU - Gonzalez-Martin, Jesus
AU  - Gonzalez-Martin J
AD  - Research Unit, Hospital de Gran Canaria Doctor Negrin, Las Palmas, GC, Spain.
FAU - Naranjo, Antonio
AU  - Naranjo A
AD  - Rheumatology Service, Hospital Universitario de Gran Canaria Doctor Negrin, Las 
      Palmas, GC, Spain.
FAU - Ojeda, Soledad
AU  - Ojeda S
AD  - Rheumatology Service, Hospital Universitario de Gran Canaria Doctor Negrin, Las 
      Palmas, GC, Spain.
FAU - Francisco, Felix
AU  - Francisco F
AD  - Rheumatology Service, Hospital Universitario de Gran Canaria Doctor Negrin, Las 
      Palmas, GC, Spain.
FAU - Quevedo, Juan C
AU  - Quevedo JC
AD  - Rheumatology Service, Hospital Universitario de Gran Canaria Doctor Negrin, Las 
      Palmas, GC, Spain.
FAU - Caceres, Laura
AU  - Caceres L
AD  - Rheumatology Service, Hospital Universitario de Gran Canaria Doctor Negrin, Las 
      Palmas, GC, Spain.
FAU - Lopez, Ruben
AU  - Lopez R
AD  - Rheumatology Service, Hospital Universitario de Gran Canaria Doctor Negrin, Las 
      Palmas, GC, Spain.
FAU - Greco, Martin
AU  - Greco M
AD  - Rheumatology Service, Hospital Universitario de Gran Canaria Doctor Negrin, Las 
      Palmas, GC, Spain.
FAU - Altabas-Gonzalez, Irene
AU  - Altabas-Gonzalez I
AD  - Rheumatology Service, Hospital Universitario de Gran Canaria Doctor Negrin, Las 
      Palmas, GC, Spain.
FAU - Perez, Yanira
AU  - Perez Y
AD  - Rheumatology Service, Hospital Universitario de Gran Canaria Doctor Negrin, Las 
      Palmas, GC, Spain.
FAU - Rubino, Francisco
AU  - Rubino F
AD  - Rheumatology Service, Hospital Universitario de Gran Canaria Doctor Negrin, Las 
      Palmas, GC, Spain.
FAU - Rodriguez-Lozano, Carlos
AU  - Rodriguez-Lozano C
AD  - Rheumatology Service, Hospital Universitario de Gran Canaria Doctor Negrin, Las 
      Palmas, GC, Spain.
LA  - eng
PT  - Journal Article
DEP - 20191127
PL  - Germany
TA  - Rheumatol Int
JT  - Rheumatology international
JID - 8206885
SB  - IM
MH  - Adult
MH  - Case-Control Studies
MH  - Cross-Sectional Studies
MH  - Female
MH  - Humans
MH  - Lupus Erythematosus, Systemic/*complications/pathology
MH  - Male
MH  - Middle Aged
MH  - Retina/*pathology
MH  - Retinal Diseases/*etiology/pathology
MH  - Retrospective Studies
MH  - Risk Factors
MH  - Tobacco Smoking/*adverse effects
OTO - NOTNLM
OT  - Lupus
OT  - Retinal
OT  - Tobacco
EDAT- 2019/11/28 06:00
MHDA- 2021/02/11 06:00
CRDT- 2019/11/28 06:00
PHST- 2019/06/17 00:00 [received]
PHST- 2019/11/01 00:00 [accepted]
PHST- 2019/11/28 06:00 [pubmed]
PHST- 2021/02/11 06:00 [medline]
PHST- 2019/11/28 06:00 [entrez]
AID - 10.1007/s00296-019-04473-8 [pii]
AID - 10.1007/s00296-019-04473-8 [doi]
PST - ppublish
SO  - Rheumatol Int. 2020 Mar;40(3):367-374. doi: 10.1007/s00296-019-04473-8. Epub 2019 
      Nov 27.