PMID- 31773429
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20210201
IS  - 0920-9069 (Print)
IS  - 1573-0778 (Electronic)
IS  - 0920-9069 (Linking)
VI  - 72
IP  - 1
DP  - 2020 Feb
TI  - In vitro anti-inflammatory effects of curcumin on mast cell-mediated allergic 
      responses via inhibiting FcepsilonRI protein expression and protein kinase C delta 
      translocation.
PG  - 81-95
LID - 10.1007/s10616-019-00359-6 [doi]
AB  - Allergy is a hypersensitivity reaction when exposed to certain environmental 
      substances. It shows high relation between immunoglobulin E (IgE) binding to a 
      specific receptor (FcepsilonRI), pro-inflammatory cytokines, and mediators with 
      allergic inflammation responses. Curcumin is a yellow pigment isolated from the 
      turmeric. Curcumin possesses antioxidant and anti-inflammatory properties as well 
      as exhibits significant chemopreventive activity. This study was aimed to 
      investigate the in vitro assessment of the regulation of curcumin on allergic 
      inflammatory responses on rat basophil leukemia (RBL)-2H3 and human pre-basophils 
      (KU812) cell lines. Curcumin showed the activity against histamine and 
      beta-hexosaminidase releases from both IgE-mediated and A23187-induced cells 
      degranulation. The morphological observation also confirmed that curcumin 
      inhibits cells degranulation. IgE-mediated allergic responses and significantly 
      induced mast cells intracellular reactive oxygen species (ROS) production. 
      Curcumin reduced ROS production from IgE-mediated or A23187-induced cells 
      degranulation. Curcumin also successfully reduced FcepsilonRI expressions and some 
      pro-inflammatory cytokines, such as interleukin (IL)-4 and IL-13. Furthermore, 
      curcumin inhibited protein kinase C (PKC)-delta translocation from cytosolic to 
      particulate. These results suggested that curcumin can alleviate both the 
      IgE-mediated and calcium ionosphere A23187-stimulated allergic responses through 
      reducing the release of the allergic mediators.
FAU - Kong, Zwe-Ling
AU  - Kong ZL
AUID- ORCID: 0000-0002-4877-6524
AD  - Department of Food Science, National Taiwan Ocean University, Keelung City, 202, 
      Taiwan. kongzl@mail.ntou.edu.tw.
FAU - Sudirman, Sabri
AU  - Sudirman S
AD  - Department of Food Science, National Taiwan Ocean University, Keelung City, 202, 
      Taiwan.
FAU - Lin, Huey-Jun
AU  - Lin HJ
AD  - Department of Food Science, National Taiwan Ocean University, Keelung City, 202, 
      Taiwan.
FAU - Chen, Wei-Ning
AU  - Chen WN
AD  - Department of Food Science, National Taiwan Ocean University, Keelung City, 202, 
      Taiwan.
LA  - eng
PT  - Journal Article
DEP - 20191126
PL  - United States
TA  - Cytotechnology
JT  - Cytotechnology
JID - 8807027
PMC - PMC7002632
OTO - NOTNLM
OT  - Allergic responses
OT  - Curcumin
OT  - Degranulation
OT  - Immunoglobulin E
OT  - Protein kinase C
COIS- The authors declare that they have no conflict of interest.
EDAT- 2019/11/28 06:00
MHDA- 2019/11/28 06:01
PMCR- 2021/02/01
CRDT- 2019/11/28 06:00
PHST- 2019/04/22 00:00 [received]
PHST- 2019/11/23 00:00 [accepted]
PHST- 2019/11/28 06:00 [pubmed]
PHST- 2019/11/28 06:01 [medline]
PHST- 2019/11/28 06:00 [entrez]
PHST- 2021/02/01 00:00 [pmc-release]
AID - 10.1007/s10616-019-00359-6 [pii]
AID - 359 [pii]
AID - 10.1007/s10616-019-00359-6 [doi]
PST - ppublish
SO  - Cytotechnology. 2020 Feb;72(1):81-95. doi: 10.1007/s10616-019-00359-6. Epub 2019 
      Nov 26.