PMID- 31773882
OWN - NLM
STAT- MEDLINE
DCOM- 20201102
LR  - 20210703
IS  - 1742-481X (Electronic)
IS  - 1742-4801 (Print)
IS  - 1742-4801 (Linking)
VI  - 17
IP  - 1
DP  - 2020 Feb
TI  - Efficacy of a povidone-iodine foam dressing (Betafoam) on diabetic foot ulcer.
PG  - 91-99
LID - 10.1111/iwj.13236 [doi]
AB  - This study aimed to assess the efficacy of a new povidone-iodine (PVP-I) foam 
      dressing (Betafoam) vs foam dressing (Medifoam) for the management of diabetic 
      foot ulcers. This study was conducted between March 2016 and September 2017 at 10 
      sites in Korea. A total of 71 patients (aged >/=19 years) with type 1/2 diabetes 
      and early-phase diabetic foot ulcers (Wagener classification grade 1/2) were 
      randomised to treatment with PVP-I foam dressing or foam dressing for 8 weeks. 
      Wound healing, wound infection, patient satisfaction, and adverse events (AEs) 
      were assessed. The PVP-I foam and foam dressing groups were comparable in the 
      proportion of patients with complete wound healing within 8 weeks (44.4% vs 
      42.3%, P = .9191), mean (+/-SD) number of days to complete healing (31.00 +/- 15.07 
      vs 33.27 +/- 12.60 days; P = .6541), and infection rates (11.1% vs 11.4%; P 
      = 1.0000). Median satisfaction score (scored from 0 to 10) at the final visit was 
      also comparable between groups (10 vs 9, P = .2889). There was no significant 
      difference in AE incidence (27.8% vs 17.1%, P = .2836), and none of the reported 
      AEs had a causal relationship with the dressings. The results of this study 
      suggest that PVP-I foam dressing has wound-healing efficacy comparable with foam 
      dressing, with no notable safety concerns. This study was funded by Mundipharma 
      Korea Ltd and registered at ClinicalTrials.gov (identifier NCT02732886).
CI  - (c) 2019 Medicalhelplines.com Inc and John Wiley & Sons Ltd.
FAU - Gwak, Heui C
AU  - Gwak HC
AUID- ORCID: 0000-0003-1062-0580
AD  - Department of Orthopedic Surgery, Busan Paik Hospital, Inje University College of 
      Medicine, Busan, South Korea.
FAU - Han, Seung H
AU  - Han SH
AD  - Department of Orthopaedic Surgery, Gangnam Severance Hospital, Yonsei University 
      College of Medicine, Seoul, South Korea.
FAU - Lee, Jinwoo
AU  - Lee J
AD  - Department of Orthopaedic Surgery, Severance Hospital, Yonsei University College 
      of Medicine, Seoul, South Korea.
FAU - Park, Sejin
AU  - Park S
AD  - Department of Orthopedic Surgery, KangBuk Samsung Hospital, SungKyunKwan 
      University School of Medicine, Seoul, South Korea.
FAU - Sung, Ki-Sun
AU  - Sung KS
AD  - Department of Orthopedic Surgery, Samsung Medical Center, Sungkyunkwan University 
      School of Medicine, Seoul, South Korea.
FAU - Kim, Hak-Jun
AU  - Kim HJ
AD  - Department of Orthopedic Surgery, Korea University Guro Hospital, Seoul, South 
      Korea.
FAU - Chun, Dongil
AU  - Chun D
AD  - Department of Orthopaedic Surgery, College of Medicine, Soonchunhyang University 
      Seoul Hospital, Seoul, South Korea.
FAU - Lee, Kyungmin
AU  - Lee K
AD  - Department of Orthopaedic Surgery, Seoul National University Bundang Hospital, 
      Kyungki, South Korea.
FAU - Ahn, Jae-Hoon
AU  - Ahn JH
AD  - Department of Orthopaedic Surgery, Seoul St. Mary's Hospital, College of 
      Medicine, the Catholic University of Korea, Seoul, South Korea.
FAU - Kwak, Kyunghee
AU  - Kwak K
AD  - Department of Medical Affairs, Mundipharma Korea Ltd, Seoul, South Korea.
FAU - Chung, Hyung-Jin
AU  - Chung HJ
AD  - Department of Orthopaedics, Inje University Sanggye Paik Hospital, Seoul, South 
      Korea.
LA  - eng
SI  - ClinicalTrials.gov/NCT02732886
GR  - -/Mundipharma Korea Ltd/
PT  - Comparative Study
PT  - Journal Article
DEP - 20191126
PL  - England
TA  - Int Wound J
JT  - International wound journal
JID - 101230907
RN  - 85H0HZU99M (Povidone-Iodine)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - *Bandages, Hydrocolloid
MH  - Diabetes Complications/*drug therapy
MH  - Diabetic Foot/*drug therapy
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Povidone-Iodine/*therapeutic use
MH  - Republic of Korea
MH  - Wound Healing/*drug effects/*physiology
MH  - Wound Infection/*drug therapy
MH  - Young Adult
PMC - PMC7949421
OTO - NOTNLM
OT  - Betafoam
OT  - Medifoam
OT  - diabetic foot ulcer
OT  - povidone-iodine
OT  - wound healing
COIS- K.K. is an employee of Mundipharma Korea Ltd. All other authors have no relevant 
      relationships to disclose.
EDAT- 2019/11/28 06:00
MHDA- 2020/11/03 06:00
PMCR- 2019/11/26
CRDT- 2019/11/28 06:00
PHST- 2019/06/24 00:00 [received]
PHST- 2019/09/11 00:00 [revised]
PHST- 2019/09/13 00:00 [accepted]
PHST- 2019/11/28 06:00 [pubmed]
PHST- 2020/11/03 06:00 [medline]
PHST- 2019/11/28 06:00 [entrez]
PHST- 2019/11/26 00:00 [pmc-release]
AID - IWJ13236 [pii]
AID - 10.1111/iwj.13236 [doi]
PST - ppublish
SO  - Int Wound J. 2020 Feb;17(1):91-99. doi: 10.1111/iwj.13236. Epub 2019 Nov 26.