PMID- 31773995
OWN - NLM
STAT- MEDLINE
DCOM- 20201125
LR  - 20201125
IS  - 1532-4206 (Electronic)
IS  - 0743-5800 (Linking)
VI  - 45
IP  - 2
DP  - 2020 Feb-May
TI  - Association between Free Thyroxine Levels and Diabetic Retinopathy in Euthyroid 
      Patients with Type 2 Diabetes Mellitus.
PG  - 111-118
LID - 10.1080/07435800.2019.1690504 [doi]
AB  - Background: This study aimed to evaluate the association between thyroid 
      parameters and diabetic retinopathy (DR) in euthyroid patients with type 2 
      diabetes mellitus (T2DM).Materials and Methods: In this cross-sectional study, a 
      total of 911 euthyroid patients with T2DM (539 men and 372 women; mean age, 
      60.81 +/- 12.93 years) were enrolled. Clinical factors were assessed and free 
      triiodothyronine (FT3), free thyroxine (FT4) and thyroid-stimulating hormone 
      (TSH) levels were measured. DR was diagnosed using fundus fluorescein 
      angiography.Results: Compared with patients without DR (n = 718), patients with 
      DR (n = 193) exhibited lower FT3 (4.40 +/- 0.58 vs. 4.50 +/- 0.51 pmol/L; P = .019) 
      and FT4 (14.86 +/- 2.09 vs. 15.91 +/- 2.18 pmol/L; P < .001) and higher TSH (1.86 
      [1.22, 2.66] vs. 1.58 [1.14, 2.34] microIU/mL; P = .015) levels. After adjustment for 
      potential DR risk factors, patients in the highest tertile of plasma FT4 levels 
      had a 0.332-fold likelihood of developing DR compared with those in the lowest 
      tertile of plasma FT4 levels (P(trend) < 0.001). The prevalence of DR showed a 
      significantly decreasing trend across the three tertiles based on FT4 levels 
      (31.35%, 19.08% and 13.16%; P(trend) < 0.001). Similar results were obtained for 
      the presence of proliferative DR.Conclusion: These findings suggest that 
      low-normal FT4 levels are associated with the prevalence of DR in euthyroid 
      patients with T2DM.
FAU - Kong, Xiaocen
AU  - Kong X
AD  - Department of Endocrinology, Nanjing First Hospital, Nanjing Medical University, 
      Nanjing, China.
FAU - Wang, Jian
AU  - Wang J
AD  - Department of intensive care unit, Women's Hospital of Nanjing Medical 
      University, Nanjing Maternity and Child Health Care Hospital, Nanjing, China.
FAU - Gao, Gu
AU  - Gao G
AD  - Department of Endocrinology, Nanjing First Hospital, Nanjing Medical University, 
      Nanjing, China.
FAU - Tan, Mingjuan
AU  - Tan M
AD  - Department of Clinical Laboratory, Nanjing First Hospital, Nanjing Medical 
      University, Nanjing, China.
FAU - Ding, Bo
AU  - Ding B
AD  - Department of Endocrinology, Nanjing First Hospital, Nanjing Medical University, 
      Nanjing, China.
FAU - Li, Huiqin
AU  - Li H
AD  - Department of Endocrinology, Nanjing First Hospital, Nanjing Medical University, 
      Nanjing, China.
FAU - Ma, Jianhua
AU  - Ma J
AD  - Department of Endocrinology, Nanjing First Hospital, Nanjing Medical University, 
      Nanjing, China.
LA  - eng
PT  - Journal Article
DEP - 20191127
PL  - England
TA  - Endocr Res
JT  - Endocrine research
JID - 8408548
RN  - 06LU7C9H1V (Triiodothyronine)
RN  - 9002-71-5 (Thyrotropin)
RN  - Q51BO43MG4 (Thyroxine)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Cross-Sectional Studies
MH  - Diabetes Mellitus, Type 2/*blood/complications/epidemiology
MH  - Diabetic Retinopathy/*blood/epidemiology/etiology
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Prevalence
MH  - Thyroid Function Tests/statistics & numerical data
MH  - Thyrotropin/*blood
MH  - Thyroxine/*blood
MH  - Triiodothyronine/*blood
OTO - NOTNLM
OT  - Diabetic retinopathy
OT  - free thyroxine
OT  - thyroid
OT  - type 2 diabetes mellitus
EDAT- 2019/11/28 06:00
MHDA- 2020/11/26 06:00
CRDT- 2019/11/28 06:00
PHST- 2019/11/28 06:00 [pubmed]
PHST- 2020/11/26 06:00 [medline]
PHST- 2019/11/28 06:00 [entrez]
AID - 10.1080/07435800.2019.1690504 [doi]
PST - ppublish
SO  - Endocr Res. 2020 Feb-May;45(2):111-118. doi: 10.1080/07435800.2019.1690504. Epub 
      2019 Nov 27.