PMID- 31775782 OWN - NLM STAT- MEDLINE DCOM- 20200601 LR - 20200601 IS - 1546-0096 (Electronic) IS - 1546-0096 (Linking) VI - 17 IP - 1 DP - 2019 Nov 27 TI - Predictive value of serum procalcitonin for both initial and repeated immunoglobulin resistance in Kawasaki disease: a prospective cohort study. PG - 78 LID - 10.1186/s12969-019-0379-5 [doi] LID - 78 AB - BACKGROUND: Intravenous immunoglobulin (IVIG) resistance prediction is one pivotal topic of interests in Kawasaki disease (KD) since those patients with KD resistant to IVIG might improve of an early-intensified therapy. Data regarding predictive value of procalcitonin (PCT) for IVIG resistance, particularly for repeated IVIG resistance in KD was limited. This study aimed to testify the predictive validity of PCT for both initial and repeated IVIG resistance in KD. METHODS: A total of 530 KD patients were prospectively recruited between January 2015 and March 2019. The clinical and laboratory data were compared between IVIG-responsive and IVIG-resistant groups. Multivariate logistic regression analysis was applied to determine the association between PCT and IVIG resistance. Receiver operating characteristic (ROC) curves analysis was further performed to assess the validity of PCT in predicting both initial and repeated IVIG resistance. RESULTS: The serum PCT level was significantly higher in initial IVIG-resistance group compared with IVIG-response group (p = 0.009), as well as between repeated IVIG responders and nonresponders (p = 0.017). The best PCT cutoff value for initial and repeated IVIG resistance prediction was 1.48 ng/ml and 2.88 ng/ml, respectively. The corresponding sensitivity was 53.9 and 51.4%, while the specificity were 71.8 and 73.2%, respectively. Multivariate logistic regression analysis failed to identify serum PCT level as an independent predictive factor for both initial and repeated IVIG resistance in KD. CONCLUSIONS: Serum PCT levels were significantly higher in IVIG nonresponders, but PCT may not be suitable as a single marker to accurately predict both initial and repeated IVIG resistance in KD. FAU - Shao, Shuran AU - Shao S AD - Department of Pediatric Cardiology, West China Second University Hospital, Sichuan University, No. 20, Section 3, South Renmin Road, Chengdu, 610041, Sichuan, China. AD - West China Medical School of Sichuan University, Chengdu, Sichuan, China. FAU - Luo, Chunyan AU - Luo C AD - Department of Radiology, West China Hospital, Sichuan University, Chengdu, Sichuan, China. FAU - Zhou, Kaiyu AU - Zhou K AD - Department of Pediatric Cardiology, West China Second University Hospital, Sichuan University, No. 20, Section 3, South Renmin Road, Chengdu, 610041, Sichuan, China. AD - The Cardiac development and early intervention unit, West China Institute of Women and Children's Health, West China Second University Hospital, Sichuan University, Chengdu, Sichuan, China. AD - Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education Chengdu, Chengdu, Sichuan, China. AD - Key Laboratory of Development and Diseases of Women and Children of Sichuan Province, West China Second University Hospital, Sichuan University, Chengdu, Sichuan, China. FAU - Hua, Yimin AU - Hua Y AUID- ORCID: 0000-0001-9331-7653 AD - Department of Pediatric Cardiology, West China Second University Hospital, Sichuan University, No. 20, Section 3, South Renmin Road, Chengdu, 610041, Sichuan, China. nathan_hua@163.com. AD - The Cardiac development and early intervention unit, West China Institute of Women and Children's Health, West China Second University Hospital, Sichuan University, Chengdu, Sichuan, China. nathan_hua@163.com. AD - Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education Chengdu, Chengdu, Sichuan, China. nathan_hua@163.com. AD - Key Laboratory of Development and Diseases of Women and Children of Sichuan Province, West China Second University Hospital, Sichuan University, Chengdu, Sichuan, China. nathan_hua@163.com. FAU - Wu, Mei AU - Wu M AD - Department of Pediatric Cardiology, West China Second University Hospital, Sichuan University, No. 20, Section 3, South Renmin Road, Chengdu, 610041, Sichuan, China. AD - West China Medical School of Sichuan University, Chengdu, Sichuan, China. FAU - Liu, Lei AU - Liu L AD - Department of Pediatric Cardiology, West China Second University Hospital, Sichuan University, No. 20, Section 3, South Renmin Road, Chengdu, 610041, Sichuan, China. AD - West China Medical School of Sichuan University, Chengdu, Sichuan, China. FAU - Liu, Xiaoliang AU - Liu X AD - Department of Pediatric Cardiology, West China Second University Hospital, Sichuan University, No. 20, Section 3, South Renmin Road, Chengdu, 610041, Sichuan, China. AD - Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education Chengdu, Chengdu, Sichuan, China. AD - Key Laboratory of Development and Diseases of Women and Children of Sichuan Province, West China Second University Hospital, Sichuan University, Chengdu, Sichuan, China. FAU - Wang, Chuan AU - Wang C AD - Department of Pediatric Cardiology, West China Second University Hospital, Sichuan University, No. 20, Section 3, South Renmin Road, Chengdu, 610041, Sichuan, China. 805101396@qq.com. AD - The Cardiac development and early intervention unit, West China Institute of Women and Children's Health, West China Second University Hospital, Sichuan University, Chengdu, Sichuan, China. 805101396@qq.com. AD - Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education Chengdu, Chengdu, Sichuan, China. 805101396@qq.com. AD - Key Laboratory of Development and Diseases of Women and Children of Sichuan Province, West China Second University Hospital, Sichuan University, Chengdu, Sichuan, China. 805101396@qq.com. LA - eng GR - 81800288/National Natural Science Foundation of China/ GR - 81571515/National Natural Science Foundation of China/ GR - 2017SZ0117/Department of Science and Technology of Sichuan Province/ PT - Journal Article DEP - 20191127 PL - England TA - Pediatr Rheumatol Online J JT - Pediatric rheumatology online journal JID - 101248897 RN - 0 (Immunoglobulins, Intravenous) RN - 0 (Procalcitonin) SB - IM MH - Child, Preschool MH - Female MH - Humans MH - Immunoglobulins, Intravenous/administration & dosage/*therapeutic use MH - Male MH - Mucocutaneous Lymph Node Syndrome/blood/*therapy MH - Predictive Value of Tests MH - Procalcitonin/*blood MH - Prospective Studies MH - Treatment Failure PMC - PMC6882026 OTO - NOTNLM OT - Immunoglobulin resistance OT - Kawasaki disease OT - Prediction OT - Procalcitonin COIS- The authors declare that they have no competing interests. EDAT- 2019/11/30 06:00 MHDA- 2020/06/02 06:00 PMCR- 2019/11/27 CRDT- 2019/11/29 06:00 PHST- 2019/07/23 00:00 [received] PHST- 2019/11/06 00:00 [accepted] PHST- 2019/11/29 06:00 [entrez] PHST- 2019/11/30 06:00 [pubmed] PHST- 2020/06/02 06:00 [medline] PHST- 2019/11/27 00:00 [pmc-release] AID - 10.1186/s12969-019-0379-5 [pii] AID - 379 [pii] AID - 10.1186/s12969-019-0379-5 [doi] PST - epublish SO - Pediatr Rheumatol Online J. 2019 Nov 27;17(1):78. doi: 10.1186/s12969-019-0379-5.