PMID- 31776697
OWN - NLM
STAT- MEDLINE
DCOM- 20200930
LR  - 20200930
IS  - 1439-6327 (Electronic)
IS  - 1439-6319 (Linking)
VI  - 120
IP  - 1
DP  - 2020 Jan
TI  - Impact of a 10 km running trial on eryptosis, red blood cell rheology, and 
      electrophysiology in endurance trained athletes: a pilot study.
PG  - 255-266
LID - 10.1007/s00421-019-04271-x [doi]
AB  - PURPOSE: Blood rheology is a key determinant of blood flow and tissue perfusion. 
      There are still large discrepancies regarding the effects of an acute running 
      exercise on blood rheological properties and red blood cell (RBC) physiology. We 
      investigated the effect of a 10 km running trial on markers of blood rheology and 
      RBC physiology in endurance trained athletes. METHODS: Blood was sampled before 
      and after the exercise to measure lactate and glucose, hematological and 
      hemorheological parameters (blood viscosity, RBC deformability, and aggregation), 
      eryptosis markers (phosphatidylserine and CD47 exposure, RBC reactive oxygen 
      species), RBC-derived microparticles (RBC-MPs), and RBC electrophysiological 
      activity. Weight was measured before and after exercise. Peripheral oxygen 
      saturation and heart rate were monitored before and during the trial. RESULTS: 
      Blood lactate and glucose levels increased after exercise and subjects 
      significantly lost weight. All athletes experienced a significant fall in oxygen 
      saturation. Mean corpuscular volume (MCV) was increased from 95.1 +/- 3.2 to 
      96.0 +/- 3.3 and mean corpuscular hemoglobin concentration (MCHC) decreased after 
      exercise suggesting a slight RBC rehydration. Exercise increased RBC 
      deformability from 0.344 +/- 0.04 to 0.378 +/- 0.07, decreased RBC aggregates 
      strength and blood viscosity, while hematocrit (Hct) remained unaffected. While 
      RBC electrophysiological recording suggested a modulation in RBC calcium content 
      and/or chloride conductance, eryptosis markers and RBC-MPs were not modified by 
      the exercise. CONCLUSION: A 10 km acute running exercise had no effect on RBC 
      senescence and membrane blebbing. In contrast, this exercise increased RBC 
      deformability, probably through rehydration process which resulted in a decrease 
      in blood viscosity.
FAU - Nader, Elie
AU  - Nader E
AD  - Laboratoire Interuniversitaire de Biologie de la Motricite (LIBM) EA7424, Team 
      "Vascular Biology and Red Blood Cell", Universite Claude Bernard Lyon 1, 
      Universite de Lyon, Lyon, France.
AD  - Laboratoire d'Excellence du Globule Rouge (Labex GR-Ex), PRES Sorbonne, Paris, 
      France.
FAU - Monedero, David
AU  - Monedero D
AD  - Laboratoire d'Excellence du Globule Rouge (Labex GR-Ex), PRES Sorbonne, Paris, 
      France.
AD  - UMR 8227 CNRS-Sorbonne Universite, Station Biologique, Place Georges Teissier, BP 
      74, 29682, Roscoff Cedex, France.
FAU - Robert, Melanie
AU  - Robert M
AD  - Laboratoire Interuniversitaire de Biologie de la Motricite (LIBM) EA7424, Team 
      "Vascular Biology and Red Blood Cell", Universite Claude Bernard Lyon 1, 
      Universite de Lyon, Lyon, France.
AD  - Laboratoire d'Excellence du Globule Rouge (Labex GR-Ex), PRES Sorbonne, Paris, 
      France.
AD  - Erytech Pharma, Lyon, France.
FAU - Skinner, Sarah
AU  - Skinner S
AD  - Laboratoire Interuniversitaire de Biologie de la Motricite (LIBM) EA7424, Team 
      "Vascular Biology and Red Blood Cell", Universite Claude Bernard Lyon 1, 
      Universite de Lyon, Lyon, France.
AD  - Laboratoire d'Excellence du Globule Rouge (Labex GR-Ex), PRES Sorbonne, Paris, 
      France.
FAU - Stauffer, Emeric
AU  - Stauffer E
AD  - Laboratoire Interuniversitaire de Biologie de la Motricite (LIBM) EA7424, Team 
      "Vascular Biology and Red Blood Cell", Universite Claude Bernard Lyon 1, 
      Universite de Lyon, Lyon, France.
AD  - Laboratoire d'Excellence du Globule Rouge (Labex GR-Ex), PRES Sorbonne, Paris, 
      France.
AD  - Centre de Medecine du Sommeil et des Maladies Respiratoires, Hopital Croix 
      Rousse, Hospices Civils de Lyon, Lyon, France.
FAU - Cibiel, Agnes
AU  - Cibiel A
AD  - Erytech Pharma, Lyon, France.
FAU - Germain, Michele
AU  - Germain M
AD  - Laboratoire Interuniversitaire de Biologie de la Motricite (LIBM) EA7424, Team 
      "Vascular Biology and Red Blood Cell", Universite Claude Bernard Lyon 1, 
      Universite de Lyon, Lyon, France.
AD  - Laboratoire d'Excellence du Globule Rouge (Labex GR-Ex), PRES Sorbonne, Paris, 
      France.
AD  - Service d'Exploration Fonctionnelle Respiratoire, Hospices Civils de Lyon, 
      Hopital Croix Rousse, Lyon, France.
FAU - Hugonnet, Jules
AU  - Hugonnet J
AD  - Service d'Exploration Fonctionnelle Respiratoire, Hospices Civils de Lyon, 
      Hopital Croix Rousse, Lyon, France.
FAU - Scheer, Alexander
AU  - Scheer A
AD  - Erytech Pharma, Lyon, France.
FAU - Joly, Philippe
AU  - Joly P
AD  - Laboratoire Interuniversitaire de Biologie de la Motricite (LIBM) EA7424, Team 
      "Vascular Biology and Red Blood Cell", Universite Claude Bernard Lyon 1, 
      Universite de Lyon, Lyon, France.
AD  - Laboratoire d'Excellence du Globule Rouge (Labex GR-Ex), PRES Sorbonne, Paris, 
      France.
AD  - Laboratoire de Biochimie et de Biologie Moleculaire, UF de Biochimie des 
      Pathologies Erythrocytaires, Centre de Biologie et de Pathologie Est, Hospices 
      Civils de Lyon, Lyon, France.
FAU - Renoux, Celine
AU  - Renoux C
AD  - Laboratoire Interuniversitaire de Biologie de la Motricite (LIBM) EA7424, Team 
      "Vascular Biology and Red Blood Cell", Universite Claude Bernard Lyon 1, 
      Universite de Lyon, Lyon, France.
AD  - Laboratoire d'Excellence du Globule Rouge (Labex GR-Ex), PRES Sorbonne, Paris, 
      France.
AD  - Laboratoire de Biochimie et de Biologie Moleculaire, UF de Biochimie des 
      Pathologies Erythrocytaires, Centre de Biologie et de Pathologie Est, Hospices 
      Civils de Lyon, Lyon, France.
FAU - Connes, Philippe
AU  - Connes P
AD  - Laboratoire Interuniversitaire de Biologie de la Motricite (LIBM) EA7424, Team 
      "Vascular Biology and Red Blood Cell", Universite Claude Bernard Lyon 1, 
      Universite de Lyon, Lyon, France. pconnes@yahoo.fr.
AD  - Laboratoire d'Excellence du Globule Rouge (Labex GR-Ex), PRES Sorbonne, Paris, 
      France. pconnes@yahoo.fr.
AD  - Institut Universitaire de France, Paris, France. pconnes@yahoo.fr.
FAU - Egee, Stephane
AU  - Egee S
AD  - Laboratoire d'Excellence du Globule Rouge (Labex GR-Ex), PRES Sorbonne, Paris, 
      France.
AD  - UMR 8227 CNRS-Sorbonne Universite, Station Biologique, Place Georges Teissier, BP 
      74, 29682, Roscoff Cedex, France.
LA  - eng
PT  - Journal Article
DEP - 20191127
PL  - Germany
TA  - Eur J Appl Physiol
JT  - European journal of applied physiology
JID - 100954790
RN  - 0 (Blood Glucose)
RN  - 33X04XA5AT (Lactic Acid)
SB  - IM
MH  - Adult
MH  - Athletes
MH  - Blood Glucose/metabolism
MH  - Cell-Derived Microparticles/metabolism
MH  - *Eryptosis
MH  - Erythrocytes/metabolism
MH  - Female
MH  - *Heart Rate
MH  - *Hemorheology
MH  - Humans
MH  - Lactic Acid/blood
MH  - Male
MH  - Oxygen Consumption
MH  - Physical Conditioning, Human/adverse effects/*methods
MH  - Running/*physiology
OTO - NOTNLM
OT  - Eryptosis
OT  - Microparticles
OT  - Red blood cell
OT  - Rheology
OT  - Running exercise
EDAT- 2019/11/30 06:00
MHDA- 2020/10/02 06:00
CRDT- 2019/11/29 06:00
PHST- 2019/08/02 00:00 [received]
PHST- 2019/11/22 00:00 [accepted]
PHST- 2019/11/30 06:00 [pubmed]
PHST- 2020/10/02 06:00 [medline]
PHST- 2019/11/29 06:00 [entrez]
AID - 10.1007/s00421-019-04271-x [pii]
AID - 10.1007/s00421-019-04271-x [doi]
PST - ppublish
SO  - Eur J Appl Physiol. 2020 Jan;120(1):255-266. doi: 10.1007/s00421-019-04271-x. 
      Epub 2019 Nov 27.