PMID- 31776997
OWN - NLM
STAT- MEDLINE
DCOM- 20191206
LR  - 20200108
IS  - 0065-2598 (Print)
IS  - 0065-2598 (Linking)
VI  - 1206
DP  - 2019
TI  - Chaperone-Mediated Autophagy.
PG  - 435-452
LID - 10.1007/978-981-15-0602-4_20 [doi]
AB  - Protein homeostasis is essential for maintaining cell survival. Protein synthesis 
      and degradation coordinately regulate protein homeostasis. Chaperone-mediated 
      autophagy (CMA) was the first lysosomal process to be discovered by which 
      intracellular components are selectively degraded. This process involves the 
      recognition of the substrate, the unfolding and translocation of the substrate, 
      and the degradation of the substrate. By degrading specific target proteins in a 
      timely manner, CMA is involved in a variety of cellular activities. In the past 
      few years, we have acquired a better understanding of how CMA is regulated. It 
      has been reported that peroxide accumulation, aging and/or other pathological 
      signals interfere with CMA function, which in turn induces neurodegenerative 
      diseases, cancer, and other diseases. Combining results from the current 
      research, we summarize the basic processes, regulatory mechanisms, and 
      physiological functions of CMA and discuss its critical role in the development 
      of diseases.
FAU - Yang, Qian
AU  - Yang Q
AD  - Department of Neurosurgery, Tangdu Hospital, The Fourth Military Medical 
      University, Xi'an, China. qianyang@fmmu.edu.cn.
FAU - Wang, Ronglin
AU  - Wang R
AD  - Department of Neurosurgery, Tangdu Hospital, The Fourth Military Medical 
      University, Xi'an, China.
FAU - Zhu, Lin
AU  - Zhu L
AD  - Department of Neurosurgery, Tangdu Hospital, The Fourth Military Medical 
      University, Xi'an, China.
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Adv Exp Med Biol
JT  - Advances in experimental medicine and biology
JID - 0121103
RN  - 0 (Molecular Chaperones)
SB  - IM
MH  - *Autophagy
MH  - Humans
MH  - Lysosomes/metabolism
MH  - *Molecular Chaperones/metabolism
MH  - Neoplasms/physiopathology
MH  - Neurodegenerative Diseases/physiopathology
OTO - NOTNLM
OT  - Basic process
OT  - Chaperone-mediated autophagy (CMA)
OT  - Microautophagy
OT  - Physiological function
OT  - Regulation
EDAT- 2019/11/30 06:00
MHDA- 2019/12/18 06:00
CRDT- 2019/11/29 06:00
PHST- 2019/11/29 06:00 [entrez]
PHST- 2019/11/30 06:00 [pubmed]
PHST- 2019/12/18 06:00 [medline]
AID - 10.1007/978-981-15-0602-4_20 [doi]
PST - ppublish
SO  - Adv Exp Med Biol. 2019;1206:435-452. doi: 10.1007/978-981-15-0602-4_20.