PMID- 31777716
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220411
IS  - 2234-8646 (Print)
IS  - 2234-8840 (Electronic)
IS  - 2234-8840 (Linking)
VI  - 22
IP  - 6
DP  - 2019 Nov
TI  - Is the Diagnostic Trial with Proton Pump Inhibitors Reasonable for School Age 
      Children with Gastroesophageal Reflux Symptoms?
PG  - 511-517
LID - 10.5223/pghn.2019.22.6.511 [doi]
AB  - PURPOSE: On the basis of evidence, we aimed to reevaluate the necessity of the 
      empirical proton pump inhibitor (PPI) trial for children with suspected 
      gastroesophageal reflux disease (GERD). METHODS: We analyzed the frequency of 
      GERD in 85 school-age children with gastroesophageal reflux (GER) symptoms, who 
      received 24-hour esophageal pH monitoring and/or upper endoscopy. According to 
      the reflux index (RI), the children were classified into normal (RI <5%), 
      intermediate (5%</= RI <10%), or abnormal (RI >/=10%) groups. RESULTS: Fifty six were 
      female and 29 were male. Their mean age was 12.6+/-0.5 (+/-standard deviation) years 
      (range: 6.8-18.6). The RI analysis showed that the normal group included 76 
      patients (89.4%), the intermediate group included 6 patients (7.1%), and the 
      abnormal group included 3 patients (3.5%). The DeMeester score was 5.93+/-4.65, 
      14.68+/-7.86 and 40.37+/-12.96 for the normal, intermediate and abnormal group, 
      respectively (p=0.001). The longest reflux time was 5.56+/-6.00 minutes, 9.53+/-7.84 
      minutes, and 19.46+/-8.35 minutes in the normal, intermediate, and abnormal group, 
      respectively (p=0.031). Endoscopic findings showed reflux esophagitis in 7 
      patients. On the basis of the Los Angeles Classification of Esophagitis, 5 of 
      these patients were included in group A, 1 patient, in group B and 1 patient, in 
      group C. CONCLUSION: The incidence of GERD was very low in school-age children 
      with GER symptoms. Therefore, injudicious diagnostic PPI trials would be 
      postponed until the actual prevalence of GERD is verified in future prospective 
      studies.
CI  - Copyright (c) 2019 by The Korean Society of Pediatric Gastroenterology, Hepatology 
      and Nutrition.
FAU - Yang, Jaeeun
AU  - Yang J
AUID- ORCID: 0000-0002-6765-4071
AD  - Department of Pediatrics, Jeju National University School of Medicine, Jeju, 
      Korea.
FAU - Lee, Jieon
AU  - Lee J
AUID- ORCID: 0000-0002-8051-302X
AD  - Department of Pediatrics, Jeju National University School of Medicine, Jeju, 
      Korea.
FAU - Lee, Hyunju
AU  - Lee H
AUID- ORCID: 0000-0003-0457-635X
AD  - Department of Pediatrics, Jeju National University School of Medicine, Jeju, 
      Korea.
FAU - Lee, Juyeon
AU  - Lee J
AUID- ORCID: 0000-0003-4172-2766
AD  - Department of Pediatrics, Jeju National University School of Medicine, Jeju, 
      Korea.
FAU - Youn, Young Mee
AU  - Youn YM
AUID- ORCID: 0000-0003-3819-8668
AD  - Department of Pediatrics, Jeju National University School of Medicine, Jeju, 
      Korea.
FAU - Choi, Jae Hong
AU  - Choi JH
AUID- ORCID: 0000-0003-3284-9407
AD  - Department of Pediatrics, Jeju National University School of Medicine, Jeju, 
      Korea.
FAU - Kim, Yoon-Joo
AU  - Kim YJ
AUID- ORCID: 0000-0002-2832-036X
AD  - Department of Pediatrics, Jeju National University School of Medicine, Jeju, 
      Korea.
FAU - Kang, Hyun Sik
AU  - Kang HS
AUID- ORCID: 0000-0002-7495-7871
AD  - Department of Pediatrics, Jeju National University School of Medicine, Jeju, 
      Korea.
FAU - Han, Kyoung Hee
AU  - Han KH
AUID- ORCID: 0000-0002-6830-7311
AD  - Department of Pediatrics, Jeju National University School of Medicine, Jeju, 
      Korea.
FAU - Kim, Seung Hyo
AU  - Kim SH
AUID- ORCID: 0000-0001-7277-3748
AD  - Department of Pediatrics, Jeju National University School of Medicine, Jeju, 
      Korea.
FAU - Kang, Ki-Soo
AU  - Kang KS
AUID- ORCID: 0000-0001-6374-8356
AD  - Department of Pediatrics, Jeju National University School of Medicine, Jeju, 
      Korea.
LA  - eng
PT  - Journal Article
DEP - 20191107
PL  - Korea (South)
TA  - Pediatr Gastroenterol Hepatol Nutr
JT  - Pediatric gastroenterology, hepatology & nutrition
JID - 101590471
PMC - PMC6856512
OTO - NOTNLM
OT  - Child
OT  - Empirical
OT  - Gastroesophageal reflux
OT  - Proton pump inhibitor
COIS- Conflict of Interest: The authors have no financial conflicts of interest.
EDAT- 2019/11/30 06:00
MHDA- 2019/11/30 06:01
PMCR- 2019/11/01
CRDT- 2019/11/29 06:00
PHST- 2019/05/19 00:00 [received]
PHST- 2019/09/30 00:00 [accepted]
PHST- 2019/11/29 06:00 [entrez]
PHST- 2019/11/30 06:00 [pubmed]
PHST- 2019/11/30 06:01 [medline]
PHST- 2019/11/01 00:00 [pmc-release]
AID - 10.5223/pghn.2019.22.6.511 [doi]
PST - ppublish
SO  - Pediatr Gastroenterol Hepatol Nutr. 2019 Nov;22(6):511-517. doi: 
      10.5223/pghn.2019.22.6.511. Epub 2019 Nov 7.