PMID- 31779460
OWN - NLM
STAT- MEDLINE
DCOM- 20191206
LR  - 20200108
IS  - 1211-9059 (Print)
IS  - 1211-9059 (Linking)
VI  - 75
IP  - 3
DP  - 2019 Summer
TI  - The use of optical coherence tomography in chiasmal compression.
PG  - 120-127
LID - 10.31348/2019/3/2 [doi]
AB  - The objective of this prospective study is to explore the benefits of optical 
      coherence tomography (OCT) in cases of optic chiasm (OC) compression by measuring 
      the thickness of the Retinal Nerve Fiber Layer (RNFL) and the Ganglion Cell Layer 
      (GCL). MATERIAL AND METHODS: 16 patients (32 eyes) with chiasmal compression were 
      included in the study. They presented no other pathology of the visual pathway or 
      of the eye globe. The second inclusion criterion was a subsequent indication of 
      decompressive surgery, either by transcranial or transnasal approach. 
      Measurements of visual acuity, visual field, RNFL and GCL were performed once 
      preoperatively and three times postoperatively (one week, 3 and 6 months 
      postoperatively). The observed peripapillary and perifoveal regions were divided 
      into quadrants. The degree (grade 0-5) of chiasmal compression was determined on 
      preoperative brain MRI (magnetic resonance imaging). In need of some data 
      analysis, participants were split into a group with no or minimal (grade 0-1) and 
      with substantial pressure (grade 2-4) on OC. RESULTS: The median global 
      peripapillary RNFL was 87 μm, the perifoveal nasal GCL 41,2 microm and the 
      temporal 44,2 microm. There was a pronounced preoperative RNFL thinning in nasal 
      (63,5 μm) and temporal (65 μm) quadrant, in comparison to the 
      age-matched normative database for RNFL thickness in the OCT protocol. There is a 
      statistically important connection between bitemporal hemianopia and RNFL, resp. 
      GCL. Larger perimetric outages is related to important OC compression, seen on 
      MRI. CONCLUSION: There exists a correlation between the thickness of the 
      peripapillary RNFL, resp. perifoveal GCL, and visual field defects in chiasmal 
      compression. Thinner preoperative RNFL does not present a statistically important 
      limiting factor for better functional outcomes after surgical decompression. 
      Horizontal asymmetry of perifoveal GCL is an indicator of compressive 
      ophthalmopathy. The grade of preoperative OC compression presents another 
      important prognostic factor.
FAU - Poczos, P
AU  - Poczos P
FAU - Kremlacek, J
AU  - Kremlacek J
FAU - Cesak, T
AU  - Cesak T
FAU - Machackova, M
AU  - Machackova M
FAU - Jiraskova, N
AU  - Jiraskova N
LA  - eng
PT  - Journal Article
TT  - Využiti opticke koherenčni tomografie u pacientů s utlakem 
      optickeho chiasmatu.
PL  - Czech Republic
TA  - Cesk Slov Oftalmol
JT  - Ceska a slovenska oftalmologie : casopis Ceske oftalmologicke spolecnosti a 
      Slovenske oftalmologicke spolecnosti
JID - 9600515
SB  - IM
MH  - Humans
MH  - Nerve Fibers
MH  - *Optic Chiasm/diagnostic imaging
MH  - Prospective Studies
MH  - Retinal Ganglion Cells
MH  - *Tomography, Optical Coherence
OTO - NOTNLM
OT  - Pituitary adenoma
OT  - compression
OT  - optic chiasm
OT  - optical coherence tomography
OT  - resection
OT  - sellar mass
EDAT- 2019/11/30 06:00
MHDA- 2019/12/18 06:00
CRDT- 2019/11/30 06:00
PHST- 2019/11/30 06:00 [entrez]
PHST- 2019/11/30 06:00 [pubmed]
PHST- 2019/12/18 06:00 [medline]
AID - 117386 [pii]
AID - 10.31348/2019/3/2 [doi]
PST - ppublish
SO  - Cesk Slov Oftalmol. 2019 Summer;75(3):120-127. doi: 10.31348/2019/3/2.