PMID- 31780136 OWN - NLM STAT- MEDLINE DCOM- 20210215 LR - 20210215 IS - 1573-2517 (Electronic) IS - 0165-0327 (Linking) VI - 264 DP - 2020 Mar 1 TI - Disrupted intrinsic functional connectivity of the cognitive control network underlies disease severity and executive dysfunction in first-episode, treatment-naive adolescent depression. PG - 455-463 LID - S0165-0327(19)31839-7 [pii] LID - 10.1016/j.jad.2019.11.076 [doi] AB - BACKGROUND: Previous neuroimaging studies have showed that imbalanced functional integration of distributed large-scale brain networks is associated with pathophysiological characteristics of major depressive disorder (MDD). However, the association between network integrative disturbances and clinical features and cognitive functions remains largely unclear in adolescent MDD. This study investigated the neural correlates of abnormal functional connectivity networks with clinical and cognitive characteristics in adolescent MDD. METHODS: Twenty-eight first-episode, treatment-naive adolescents with MDD and 24 well-matched healthy controls (HCs) underwent functional magnetic resonance imaging (fMRI) and a battery of cognitive tests. A seed-based functional connectivity (FC) approach was used to depict connectivity patterns of the cognitive control network (CCN), affective network (AN) and default mode network (DMN), whose between-group differences were correlated with clinical variables and cognitive functions in the patients. RESULTS: Compared with the HCs, the MDD patients exhibited impaired executive functions. The FC analysis revealed lower CCN FC with the temporal, parietal and frontal regions and the limbic system, higher AN FC with the temporal and occipital regions and the cerebellum, and lower DMN FC with the cerebellum and insula. Interestingly, the decreased CCN FC was related to disease severity (with the inferior frontal gyrus) and executive dysfunctions (with the middle cingulate gyrus and supramarginal gyrus) in the patients. LIMITATIONS: The main limitations were the relatively small sample size and suboptimal imaging parameters. CONCLUSION: Functional alteration of CCN during the developmentally sensitive period may be important in the neurobiology of adolescent MDD. CI - Copyright (c) 2019. Published by Elsevier B.V. FAU - Pan, Fen AU - Pan F AD - Department of Psychiatry, First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China; The Key Laboratory of Mental Disorder's Management of Zhejiang Province, Hangzhou, China. FAU - Xu, Yi AU - Xu Y AD - Department of Psychiatry, First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China; The Key Laboratory of Mental Disorder's Management of Zhejiang Province, Hangzhou, China. FAU - Zhou, Weihua AU - Zhou W AD - Department of Psychiatry, First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China; The Key Laboratory of Mental Disorder's Management of Zhejiang Province, Hangzhou, China. FAU - Chen, Jinkai AU - Chen J AD - Department of Psychiatry, First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China; The Key Laboratory of Mental Disorder's Management of Zhejiang Province, Hangzhou, China. FAU - Wei, Ning AU - Wei N AD - Department of Psychiatry, First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China; The Key Laboratory of Mental Disorder's Management of Zhejiang Province, Hangzhou, China. FAU - Lu, Shaojia AU - Lu S AD - Department of Psychiatry, First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China; The Key Laboratory of Mental Disorder's Management of Zhejiang Province, Hangzhou, China. FAU - Shang, Desheng AU - Shang D AD - Department of Radiology, First Affiliated Hospital, College of Medicine, Zhejiang University, The Key Laboratory of Mental Disorder's Management of Zhejiang Province, Hangzhou, China. FAU - Wang, Jinhui AU - Wang J AD - Institute for Brain Research and Rehabilitation, Guangdong Key Laboratory of Mental Health and Cognitive Science, Center for Studies of Psychological Application, South China Normal University, Guangzhou, China. Electronic address: jinhui.wang.1982@m.scnu.edu.cn. FAU - Huang, Manli AU - Huang M AD - Department of Psychiatry, First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China; The Key Laboratory of Mental Disorder's Management of Zhejiang Province, Hangzhou, China. Electronic address: huangmanli@zju.edu.cn. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20191113 PL - Netherlands TA - J Affect Disord JT - Journal of affective disorders JID - 7906073 SB - IM MH - Adolescent MH - Brain/diagnostic imaging MH - Brain Mapping MH - Cognition MH - Depression MH - *Depressive Disorder, Major/diagnostic imaging MH - Humans MH - Magnetic Resonance Imaging MH - Neural Pathways/diagnostic imaging MH - Severity of Illness Index OTO - NOTNLM OT - Adolescent depression OT - Cognitive control network OT - Cognitive function OT - Functional connectivity OT - Resting-state fMRI COIS- Declaration of Competing Interest All authors declare no conflicts of interest. EDAT- 2019/11/30 06:00 MHDA- 2021/02/16 06:00 CRDT- 2019/11/30 06:00 PHST- 2019/07/14 00:00 [received] PHST- 2019/10/01 00:00 [revised] PHST- 2019/11/12 00:00 [accepted] PHST- 2019/11/30 06:00 [pubmed] PHST- 2021/02/16 06:00 [medline] PHST- 2019/11/30 06:00 [entrez] AID - S0165-0327(19)31839-7 [pii] AID - 10.1016/j.jad.2019.11.076 [doi] PST - ppublish SO - J Affect Disord. 2020 Mar 1;264:455-463. doi: 10.1016/j.jad.2019.11.076. Epub 2019 Nov 13.