PMID- 31780926 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20201001 IS - 1663-9812 (Print) IS - 1663-9812 (Electronic) IS - 1663-9812 (Linking) VI - 10 DP - 2019 TI - Adverse Events Associated With Treatment of Tripterygium wilfordii Hook F: A Quantitative Evidence Synthesis. PG - 1250 LID - 10.3389/fphar.2019.01250 [doi] LID - 1250 AB - Background: Tripterygium wilfordii Hook F can cause adverse effects (AEs) in clinical application and may be harmful to human health. This study aim to summarize the AEs caused by T. wilfordii tgpolyglycoside (TWP), the most common preparation of T. wilfordii Hook F for clinical use. Methods: The Cochrane Library, EMBASE, PubMed, and Web of Science were searched to identify potential articles on this topic. All single-arm trials, controlled clinical trials, and randomized controlled trials were selected and summarized. Meta-regression was used to determine the sources of heterogeneity, and subgroups were used to identify factors leading to AEs. Results: Forty-six studies, comprising 25 randomized controlled trials, 13 controlled clinical trials, and 8 single-arm trials, were included in this meta-analysis, representing 2437 enrolled TWP-treated participants. Combined intervention, drug dosage, medication treatment, pharmaceutical manufacturers, and specific organ toxicity were identified as potential factors leading to TWP-induced AEs in this meta-analysis. In patients treated with TWP, the global incidence of AEs was 30.75% (95% confidence interval [21.18-40.33], I (2) = 97%), and that of severe grade AEs was 4.68% (95% confidence interval [0.00-12.72], I (2) = 53%). Organ-specific analyses indicated that TWP treatment elicited intestinal toxicity, reproductive toxicity, hepatotoxicity, nephrotoxicity, hematotoxicity, cutaneous toxicity, and other damages. The AEs analyzed in the subgroups of combined intervention, drug dosage, medication treatment, and pharmaceutical manufacturers were considered as primary outcomes, and organic-specific AEs were considered as secondary outcomes. Conclusions: The occurrence of TWP-induced AEs was systemic, organ-specific, and related to medication course, combined intervention, and drug dosage. CI - Copyright (c) 2019 Ru, Luo, Zhou, Kuai, Sun, Xing, Liu, Lu, Hong, Chen, Song, Luo, Fei, Li and Li. FAU - Ru, Yi AU - Ru Y AD - Department of Dermatology, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China. AD - Institute of Dermatology, Shanghai Academy of Traditional Chinese Medicine, Shanghai, China. FAU - Luo, Ying AU - Luo Y AD - Department of Dermatology, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China. AD - Institute of Dermatology, Shanghai Academy of Traditional Chinese Medicine, Shanghai, China. FAU - Zhou, Yaqiong AU - Zhou Y AD - Department of Dermatology, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China. AD - Institute of Dermatology, Shanghai Academy of Traditional Chinese Medicine, Shanghai, China. FAU - Kuai, Le AU - Kuai L AD - Department of Dermatology, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China. AD - Institute of Dermatology, Shanghai Academy of Traditional Chinese Medicine, Shanghai, China. FAU - Sun, Xiaoying AU - Sun X AD - Department of Dermatology, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China. AD - Institute of Dermatology, Shanghai Academy of Traditional Chinese Medicine, Shanghai, China. FAU - Xing, Meng AU - Xing M AD - Department of Dermatology, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China. AD - Institute of Dermatology, Shanghai Academy of Traditional Chinese Medicine, Shanghai, China. FAU - Liu, Liu AU - Liu L AD - Department of Dermatology, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China. AD - Institute of Dermatology, Shanghai Academy of Traditional Chinese Medicine, Shanghai, China. FAU - Lu, Yi AU - Lu Y AD - Department of Dermatology, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China. AD - Institute of Dermatology, Shanghai Academy of Traditional Chinese Medicine, Shanghai, China. FAU - Hong, Seokgyeong AU - Hong S AD - Department of Dermatology, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China. AD - Institute of Dermatology, Shanghai Academy of Traditional Chinese Medicine, Shanghai, China. FAU - Chen, Xi AU - Chen X AD - Department of Dermatology, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China. AD - Institute of Dermatology, Shanghai Academy of Traditional Chinese Medicine, Shanghai, China. FAU - Song, Jiankun AU - Song J AD - Department of Dermatology, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China. AD - Institute of Dermatology, Shanghai Academy of Traditional Chinese Medicine, Shanghai, China. FAU - Luo, Yue AU - Luo Y AD - Department of Dermatology, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China. AD - Institute of Dermatology, Shanghai Academy of Traditional Chinese Medicine, Shanghai, China. FAU - Fei, Xiaoya AU - Fei X AD - Department of Dermatology, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China. AD - Institute of Dermatology, Shanghai Academy of Traditional Chinese Medicine, Shanghai, China. FAU - Li, Bin AU - Li B AD - Department of Dermatology, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China. AD - Institute of Dermatology, Shanghai Academy of Traditional Chinese Medicine, Shanghai, China. FAU - Li, Xin AU - Li X AD - Department of Dermatology, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China. AD - Institute of Dermatology, Shanghai Academy of Traditional Chinese Medicine, Shanghai, China. LA - eng PT - Systematic Review DEP - 20191106 PL - Switzerland TA - Front Pharmacol JT - Frontiers in pharmacology JID - 101548923 PMC - PMC6851843 OTO - NOTNLM OT - Tripterygium wilfordii Hook F OT - Tripterygium wilfordii tgpolyglycoside OT - adverse events OT - meta-analysis OT - systematic review EDAT- 2019/11/30 06:00 MHDA- 2019/11/30 06:01 PMCR- 2019/11/06 CRDT- 2019/11/30 06:00 PHST- 2019/05/25 00:00 [received] PHST- 2019/09/27 00:00 [accepted] PHST- 2019/11/30 06:00 [entrez] PHST- 2019/11/30 06:00 [pubmed] PHST- 2019/11/30 06:01 [medline] PHST- 2019/11/06 00:00 [pmc-release] AID - 10.3389/fphar.2019.01250 [doi] PST - epublish SO - Front Pharmacol. 2019 Nov 6;10:1250. doi: 10.3389/fphar.2019.01250. eCollection 2019.