PMID- 31781013
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20201001
IS  - 1664-2295 (Print)
IS  - 1664-2295 (Electronic)
IS  - 1664-2295 (Linking)
VI  - 10
DP  - 2019
TI  - Correlation Between Diabetic Cognitive Impairment and Diabetic Retinopathy in 
      Patients With T2DM by (1)H-MRS.
PG  - 1068
LID - 10.3389/fneur.2019.01068 [doi]
LID - 1068
AB  - Objective: To explore the correlation between diabetic cognitive impairment (DCI) 
      and diabetic retinopathy (DR) through examining the cognitive function and the 
      metabolism of the cerebrum in Type 2 diabetes mellitus (T2DM) by (1)H-MRS. 
      Methods: Fifty-three patients with T2DM were enrolled for this study. According 
      to the fundus examination, the patients were divided into the DR group (n = 26) 
      and the T2DM without DR group (T2DM group, n = 27). Thirty healthy adults were 
      selected as a control group (HC group, n = 30). Cognitive function was measured 
      by Montreal Cognitive Assessment (MoCA). The peak areas of N-acetylaspartate 
      (NAA), Cho-line (Cho), Creatine (Cr), and Myo-inositol (mI) as well as their 
      ratios were detected by proton magnetic resonance spectroscopy ((1)H-MRS). The 
      difference analysis between the three groups was performed by one-way ANOVA. When 
      p < 0.05, LSD-t was applied. A partial correlation analysis (with age as a 
      covariate) was used to analyze the correlation between metabolites in the DR 
      group and MoCA scores. Among all T2DM patients, Chi-square test age, gender, 
      education level, BMI, SBP, DBP, FPG, HbA1c, TC, TG, HDL-C, LDL-C, DR, and DCI 
      correlation were measured. Differences were statistically significant while P < 
      0.05. Results: 1. The scores of MoCA in the DR group or in the T2DM group were 
      significantly less than those in the HC group (F = 3.54, P < 0.05), and the 
      scores of MoCA in the DR group were significantly less than those in the other 
      groups (F = 3.61, P < 0.05). 2. There were significant differences for NAA in the 
      bilateral hippocampus in DR patients, T2DM patients, and healthy controls (P < 
      0.05). 3. The NAA/Cr was significantly positively correlated with the score of 
      MoCA in DR patients' left hippocampus (r = 0.781, P < 0.01). 4. Chi-square 
      analysis found that there was a correlation between DR and DCI (x (2) = 4.6, df = 
      1, p = 0.032, plt: 0.05). There was no correlation between other influencing 
      factors and DCI (P > 0.05). Conclusion: DCI is closely correlated with the DR in 
      patients with T2DM. Hippocampal brain metabolism may have some changes in two 
      sides of NAA in patients with DR, (1)H-MRS may provide effective imaging 
      strategies and methods for the early diagnosis of brain damage and quantitative 
      assessment cognitive function in T2DM.
CI  - Copyright (c) 2019 Lu, Gong, Wen, Hu, Peng and Zha.
FAU - Lu, Xuefang
AU  - Lu X
AD  - Department of Radiology, Renmin Hospital, Wuhan, China.
FAU - Gong, Wei
AU  - Gong W
AD  - Department of Radiology, Renmin Hospital, Wuhan, China.
FAU - Wen, Zhi
AU  - Wen Z
AD  - Department of Radiology, Renmin Hospital, Wuhan, China.
FAU - Hu, Lanhua
AU  - Hu L
AD  - Department of Radiology, Renmin Hospital, Wuhan, China.
FAU - Peng, Zhoufeng
AU  - Peng Z
AD  - Department of Radiology, Renmin Hospital, Wuhan, China.
FAU - Zha, Yunfei
AU  - Zha Y
AD  - Department of Radiology, Renmin Hospital, Wuhan, China.
LA  - eng
PT  - Journal Article
DEP - 20191112
PL  - Switzerland
TA  - Front Neurol
JT  - Frontiers in neurology
JID - 101546899
PMC - PMC6861416
OTO - NOTNLM
OT  - 1H-MRS
OT  - MoCA
OT  - T2DM
OT  - diabetic brain damage
OT  - diabetic retinopathy
OT  - hippocampus
EDAT- 2019/11/30 06:00
MHDA- 2019/11/30 06:01
PMCR- 2019/11/12
CRDT- 2019/11/30 06:00
PHST- 2019/04/14 00:00 [received]
PHST- 2019/09/23 00:00 [accepted]
PHST- 2019/11/30 06:00 [entrez]
PHST- 2019/11/30 06:00 [pubmed]
PHST- 2019/11/30 06:01 [medline]
PHST- 2019/11/12 00:00 [pmc-release]
AID - 10.3389/fneur.2019.01068 [doi]
PST - epublish
SO  - Front Neurol. 2019 Nov 12;10:1068. doi: 10.3389/fneur.2019.01068. eCollection 
      2019.