PMID- 31781300
OWN - NLM
STAT- MEDLINE
DCOM- 20200427
LR  - 20220411
IS  - 1875-8630 (Electronic)
IS  - 0278-0240 (Print)
IS  - 0278-0240 (Linking)
VI  - 2019
DP  - 2019
TI  - Determination of SIRT1 rs12778366, FGFR2 rs2981582, STAT3 rs744166, and RAGE 
      rs1800625 Single Gene Polymorphisms in Patients with Laryngeal Squamous Cell 
      Carcinoma.
PG  - 3907232
LID - 10.1155/2019/3907232 [doi]
LID - 3907232
AB  - PURPOSE: To determine the frequency of the genotype of signal transducer and 
      activator of transcription protein 3 (STAT3) rs744166, sirtuin (SIRT1) 
      rs12778366, fibroblast growth factor (FGFR2) rs2981582, and advanced 
      glycosylation end product-specific receptor (RAGE) rs1800625 gene polymorphisms 
      in patients with laryngeal squamous cell carcinoma (LSCC). METHODS: A total of 
      944 subjects were evaluated, which includes 144 patients with LSCC and 800 
      healthy controls. The genotyping of STAT3 rs744166, SIRT1 rs12778366, FGFR2 
      rs2981582, and RAGE rs1800625 was carried out using the RT-PCR. RESULTS: The 
      analysis of STAT3 rs744166, SIRT1 rs12778366, and FGFR2 rs2981582 gene 
      polymorphisms did not reveal any differences in genotype distribution between the 
      patients with LSCC and the control subjects. However, statistical analysis 
      revealed that genotypes (AA, AG, and GG) of rs1800625 in RAGE gene were 
      distributed statistically significantly differently between patients and controls 
      (61.1%, 30.6%, and 23.6% vs. 72.5%, 25.8%, and 1.8%, respectively; p < 0.001). 
      Additionally, statistical significance was observed in allele distribution 
      between these two groups, i.e., allele G at rs1800625 was more frequently 
      observed in the patient group than in controls (23.6% vs. 14.6%; p < 0.001). 
      CONCLUSION: RAGE rs1800625 gene polymorphism may play a significant role in 
      laryngeal squamous cell carcinoma development.
CI  - Copyright (c) 2019 Virgilijus Uloza et al.
FAU - Uloza, Virgilijus
AU  - Uloza V
AD  - Department of Otolaryngology, Academy of Medicine, Lithuanian University of 
      Health Sciences, Kaunas, Lithuania.
FAU - Tamauskaite, Toma
AU  - Tamauskaite T
AD  - Academy of Medicine, Lithuanian University of Health Sciences, Kaunas, Lithuania.
FAU - Vilkeviciute, Alvita
AU  - Vilkeviciute A
AUID- ORCID: 0000-0002-0427-5568
AD  - Neuroscience Institute, Lithuanian University of Health Sciences, Kaunas, 
      Lithuania.
FAU - Pasvenskaite, Agne
AU  - Pasvenskaite A
AD  - Department of Otolaryngology, Academy of Medicine, Lithuanian University of 
      Health Sciences, Kaunas, Lithuania.
FAU - Liutkevicius, Vykintas
AU  - Liutkevicius V
AUID- ORCID: 0000-0002-7349-4844
AD  - Department of Otolaryngology, Academy of Medicine, Lithuanian University of 
      Health Sciences, Kaunas, Lithuania.
FAU - Liutkeviciene, Rasa
AU  - Liutkeviciene R
AUID- ORCID: 0000-0001-5395-923X
AD  - Neuroscience Institute, Lithuanian University of Health Sciences, Kaunas, 
      Lithuania.
LA  - eng
PT  - Journal Article
DEP - 20191112
PL  - United States
TA  - Dis Markers
JT  - Disease markers
JID - 8604127
RN  - 0 (Antigens, Neoplasm)
RN  - 0 (Biomarkers, Tumor)
RN  - 0 (STAT3 Transcription Factor)
RN  - 0 (STAT3 protein, human)
RN  - EC 2.7.10.1 (FGFR2 protein, human)
RN  - EC 2.7.10.1 (Receptor, Fibroblast Growth Factor, Type 2)
RN  - EC 2.7.11.22 (MOK protein, human)
RN  - EC 2.7.11.24 (Mitogen-Activated Protein Kinases)
RN  - EC 3.5.1.- (SIRT1 protein, human)
RN  - EC 3.5.1.- (Sirtuin 1)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Antigens, Neoplasm/*genetics
MH  - Biomarkers, Tumor/genetics
MH  - Carcinoma, Squamous Cell/*genetics/pathology
MH  - Case-Control Studies
MH  - Female
MH  - Follow-Up Studies
MH  - Genetic Predisposition to Disease
MH  - Genotype
MH  - Humans
MH  - Laryngeal Neoplasms/*genetics/pathology
MH  - Male
MH  - Middle Aged
MH  - Mitogen-Activated Protein Kinases/*genetics
MH  - *Polymorphism, Single Nucleotide
MH  - Prognosis
MH  - Receptor, Fibroblast Growth Factor, Type 2/*genetics
MH  - STAT3 Transcription Factor/*genetics
MH  - Sirtuin 1/*genetics
MH  - Young Adult
PMC - PMC6875326
COIS- None of the authors has any proprietary interests or conflicts of interest 
      related to this submission.
EDAT- 2019/11/30 06:00
MHDA- 2020/04/28 06:00
PMCR- 2019/11/12
CRDT- 2019/11/30 06:00
PHST- 2019/04/07 00:00 [received]
PHST- 2019/09/28 00:00 [accepted]
PHST- 2019/11/30 06:00 [entrez]
PHST- 2019/11/30 06:00 [pubmed]
PHST- 2020/04/28 06:00 [medline]
PHST- 2019/11/12 00:00 [pmc-release]
AID - 10.1155/2019/3907232 [doi]
PST - epublish
SO  - Dis Markers. 2019 Nov 12;2019:3907232. doi: 10.1155/2019/3907232. eCollection 
      2019.