PMID- 31781432
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20201001
IS  - 2090-6625 (Print)
IS  - 2090-6633 (Electronic)
VI  - 2019
DP  - 2019
TI  - Infectious Trigger for Autoimmune Encephalitis: A Case Report and Literature 
      Review.
PG  - 5731969
LID - 10.1155/2019/5731969 [doi]
LID - 5731969
AB  - Herpes simplex virus 1 infection is a common cause of encephalitis (HSVE) in the 
      United States. Post-HSVE development of N-methyl-D-aspartate receptor (NMDAR) 
      antibodies resulting in autoimmune encephalitis is a rare complication, primarily 
      affecting children and young adults. Anti-NMDAR develops 1-4 weeks after HSVE, 
      manifesting as choreoathetosis and/or orofacial dyskinesia in children and 
      psychiatric symptoms in young adults. We describe a case of a 61-year-old male 
      who presented with agitation, behavioral changes, and confusion eight months 
      after being treated for HSVE. Extensive investigation was unrevealing except for 
      cerebrospinal fluid lymphocytic pleocytosis, a positive anti-NMDAR Ab titer 
      1 : 64, and imaging changes consistent with postviral encephalitis suggestive of 
      HSV-induced anti-NMDAR encephalitis. Aggressive therapy resulted in limited 
      success and persistent neurologic deficits. The unique features of this case are 
      the old age of the patient and preceding HSVE which triggered this autoimmune 
      process. Physicians should consider anti-NMDAR encephalitis in the differentials 
      for relapsing patients after HSVE.
CI  - Copyright (c) 2019 Najmus Sahar et al.
FAU - Sahar, Najmus
AU  - Sahar N
AUID- ORCID: 0000-0001-5554-7650
AD  - Wright State University Boonshoft School of Medicine, Miami Valley Hospital, 
      Dayton, Ohio, USA.
FAU - Nurre, Alexander Michael
AU  - Nurre AM
AD  - Boonshaft School of Medicine, Class 2019, Dayton, Ohio, USA.
FAU - Simon, Ryan Q
AU  - Simon RQ
AD  - Wright State University Boonshoft School of Medicine, Miami Valley Hospital, 
      Dayton, Ohio, USA.
LA  - eng
PT  - Case Reports
DEP - 20191106
PL  - Egypt
TA  - Case Rep Infect Dis
JT  - Case reports in infectious diseases
JID - 101573243
PMC - PMC6875379
COIS- All of the authors declare that there are no conflicts of interest regarding the 
      publication of this paper.
EDAT- 2019/11/30 06:00
MHDA- 2019/11/30 06:01
PMCR- 2019/11/06
CRDT- 2019/11/30 06:00
PHST- 2019/06/19 00:00 [received]
PHST- 2019/09/05 00:00 [accepted]
PHST- 2019/11/30 06:00 [entrez]
PHST- 2019/11/30 06:00 [pubmed]
PHST- 2019/11/30 06:01 [medline]
PHST- 2019/11/06 00:00 [pmc-release]
AID - 10.1155/2019/5731969 [doi]
PST - epublish
SO  - Case Rep Infect Dis. 2019 Nov 6;2019:5731969. doi: 10.1155/2019/5731969. 
      eCollection 2019.