PMID- 31781647
OWN - NLM
STAT- MEDLINE
DCOM- 20200413
LR  - 20220411
IS  - 2314-6141 (Electronic)
IS  - 2314-6133 (Print)
VI  - 2019
DP  - 2019
TI  - Optical Coherence Tomography of Animal Models of Retinitis Pigmentosa: From 
      Animal Studies to Clinical Applications.
PG  - 8276140
LID - 10.1155/2019/8276140 [doi]
LID - 8276140
AB  - PURPOSE: The aim of this study was to understand the relationship between the 
      findings of spectral-domain optical coherence tomography (SD-OCT) of previously 
      reported animal models of retinitis pigmentosa (RP) associated with known genetic 
      mutations and their background structural and functional changes. METHODS: We 
      reviewed previous publications reporting the SD-OCT findings of animal models of 
      RP and summarized the characteristic findings of SD-OCT in nine different animal 
      models (RCS (-/-) , RHO P23H, RHO S334ter, RHO (-/-) , Rpe65 (-/-) , rp12, Pde6beta 
      (-/-) (rd1 and rd10), and Arr1 (-/-) ) of human RP. RESULTS: Despite the various 
      abnormal structural changes found in these different animal models, progressive 
      thinning of the outer nuclear layer (ONL) and hyperreflective change in the inner 
      and outer segment (IS-OS) layers of the photoreceptors were commonly observed on 
      SD-OCT. In the rapidly progressive severe photoreceptor degeneration seen in rd10 
      and Arr1 (-/-) mice, the ONL appeared hyperreflective. Electroretinography 
      revealed various degrees of disease severity in these animal models. Discussion 
      and Conclusion: SD-OCT is sensitive enough to detect even mild changes in the 
      photoreceptor OS. Conversely, SD-OCT cannot qualitatively differentiate the 
      pathologic and functional differences in the photoreceptors associated with 
      different genetic abnormalities, with the exception of the rapid progression of 
      severe forms of photoreceptor degeneration. These findings can be of value to 
      understand better the clinical findings and the heterogeneous degenerative 
      processes in patients with RP.
CI  - Copyright (c) 2019 Mitsuru Nakazawa et al.
FAU - Nakazawa, Mitsuru
AU  - Nakazawa M
AUID- ORCID: 0000-0001-6095-5712
AD  - Department of Ophthalmology, Hirosaki University Graduate School of Medicine, 
      Hirosaki, Japan.
FAU - Hara, Aiko
AU  - Hara A
AD  - Department of Ophthalmology, Hirosaki University Graduate School of Medicine, 
      Hirosaki, Japan.
FAU - Ishiguro, Sei-Ichi
AU  - Ishiguro SI
AD  - Department of Ophthalmology, Tohoku University Graduate School of Medicine, 
      Sendai, Japan.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20191030
PL  - United States
TA  - Biomed Res Int
JT  - BioMed research international
JID - 101600173
RN  - 0 (Arrestins)
RN  - 0 (arrestin 1 protein, mouse)
RN  - 9009-81-8 (Rhodopsin)
RN  - EC 3.1.1.64 (retinoid isomerohydrolase)
RN  - EC 3.1.4.35 (Cyclic Nucleotide Phosphodiesterases, Type 6)
RN  - EC 3.1.4.35 (Pde6b protein, mouse)
RN  - EC 5.2.- (cis-trans-Isomerases)
RN  - Retinitis Pigmentosa 12
SB  - IM
MH  - Animals
MH  - Arrestins/genetics
MH  - Cyclic Nucleotide Phosphodiesterases, Type 6/genetics
MH  - *Disease Models, Animal
MH  - Humans
MH  - Mice
MH  - Mice, Knockout
MH  - Rats
MH  - Rats, Transgenic
MH  - Retina/diagnostic imaging/pathology
MH  - Retinal Degeneration/diagnostic imaging/pathology
MH  - Retinitis Pigmentosa/*diagnostic imaging/genetics/*pathology
MH  - Rhodopsin/genetics
MH  - Tomography, Optical Coherence/*methods
MH  - cis-trans-Isomerases/genetics
PMC - PMC6875330
COIS- The authors declare that they have no conflicts of interest.
EDAT- 2019/11/30 06:00
MHDA- 2020/04/14 06:00
PMCR- 2019/10/30
CRDT- 2019/11/30 06:00
PHST- 2019/08/21 00:00 [received]
PHST- 2019/09/18 00:00 [accepted]
PHST- 2019/11/30 06:00 [entrez]
PHST- 2019/11/30 06:00 [pubmed]
PHST- 2020/04/14 06:00 [medline]
PHST- 2019/10/30 00:00 [pmc-release]
AID - 10.1155/2019/8276140 [doi]
PST - epublish
SO  - Biomed Res Int. 2019 Oct 30;2019:8276140. doi: 10.1155/2019/8276140. eCollection 
      2019.