PMID- 31782017 OWN - NLM STAT- MEDLINE DCOM- 20200604 LR - 20200604 IS - 1573-2649 (Electronic) IS - 0962-9343 (Linking) VI - 29 IP - 3 DP - 2020 Mar TI - Responsiveness and minimal clinically important difference of TNO-AZL Preschool Children Quality of Life in children with cerebral palsy. PG - 825-831 LID - 10.1007/s11136-019-02370-y [doi] AB - PURPOSE: To examine the responsiveness and minimal clinically important difference (MCID) of the TNO-AZL (Netherlands Organization for Applied Scientific Research Academic Medical Centre) Preschool Children Quality of Life (TAPQOL) in children with cerebral palsy (CP). METHODS: Ninety-seven children with CP (60 males, 37 females; aged 1-6 years) and their caregivers were recruited from the rehabilitation programs of Chang Gung Memorial Hospital in Taiwan for this 6-month longitudinal follow-up study. The Functional Independence Measure for Children (WeeFIM) and TAPQOL outcomes were measured at baseline and at a 6-month follow-up. Responsiveness was examined using the standardized response mean (SRM). The distribution-based and anchor-based MCID were determined. The TAPQOL outcomes include physical functioning (PF), social functioning (SF), cognitive functioning (CF), and emotional functioning (EF) domains. RESULTS: The responsiveness of the TAPQOL for all of TAPQOL domains was marked (SRM = 1.12-1.54). The anchor-based MCIDs of TAPQOL for PF, SF, CF, EF, and total domains were 1.25, 3.28, 2.93, 2.25, and 1.73, respectively, which were similar to the distribution-based MCID values of TAPQOL, except in the PF domain. The distribution-based MCIDs of TAPQOL in various domains were 2.85-3.73 when effect size (ES) was 0.2, 7.13-9.32 when ES was 0.5, and 11.40-14.91 when ES was 0.8. CONCLUSIONS: TAPQOL is markedly responsive to detect change in children with CP. The caregivers perceived the minimally important change in HRQOL of their children at a relatively low treatment efficacy. Researchers and clinicians can utilize TAPQOL data to determine whether changes in TAPQOL scores indicate clinically meaningful effects post-treatment and at the follow-up. FAU - Chen, Chia-Ling AU - Chen CL AUID- ORCID: 0000-0003-0566-1716 AD - Department of Physical Medicine and Rehabilitation, Chang Gung Memorial Hospital, Linkou, 5 Fu-Hsing St. Kwei-Shan, Tao-Yuan, 333, Taiwan. clingchen@gmail.com. AD - Graduate Institute of Early Intervention, College of Medicine, Chang Gung University, 259 Wen-Hwa 1st Rd, Kwei-Shan, Tao-Yuan, 333, Taiwan. clingchen@gmail.com. FAU - Shen, I-Hsuan AU - Shen IH AD - Department of Physical Medicine and Rehabilitation, Chang Gung Memorial Hospital, Linkou, 5 Fu-Hsing St. Kwei-Shan, Tao-Yuan, 333, Taiwan. AD - Department of Occupational Therapy, College of Medicine, Chang Gung University, 259 Wen-Hwa 1st Rd, Kwei-Shan, Tao-Yuan, 333, Taiwan. FAU - Huang, Hsiang-Han AU - Huang HH AD - Department of Physical Medicine and Rehabilitation, Chang Gung Memorial Hospital, Linkou, 5 Fu-Hsing St. Kwei-Shan, Tao-Yuan, 333, Taiwan. AD - Department of Occupational Therapy, College of Medicine, Chang Gung University, 259 Wen-Hwa 1st Rd, Kwei-Shan, Tao-Yuan, 333, Taiwan. FAU - Chen, Chung-Yao AU - Chen CY AD - Department of Physical Medicine and Rehabilitation, Chang Gung Memorial Hospital, Keelung, 222 Maijin Rd, Keelung, 204, Taiwan. AD - School of Medicine, College of Medicine, Chang Gung University, 259 Wen-Hwa 1st Rd, Kwei-Shan, Tao-Yuan, 333, Taiwan. FAU - Hsiao, Yi-Ting AU - Hsiao YT AD - Graduate Institute of Early Intervention, College of Medicine, Chang Gung University, 259 Wen-Hwa 1st Rd, Kwei-Shan, Tao-Yuan, 333, Taiwan. FAU - Wu, Ching-Yi AU - Wu CY AD - Department of Physical Medicine and Rehabilitation, Chang Gung Memorial Hospital, Linkou, 5 Fu-Hsing St. Kwei-Shan, Tao-Yuan, 333, Taiwan. AD - Department of Occupational Therapy, College of Medicine, Chang Gung University, 259 Wen-Hwa 1st Rd, Kwei-Shan, Tao-Yuan, 333, Taiwan. FAU - Chen, Hsieh-Ching AU - Chen HC AD - Department of Industrial Engineering and Management, National Taipei University of Technology, Taipei, Taiwan. LA - eng GR - NSC 98-2314-B-182-006-MY3/Ministry of Science and Technology, Taiwan (TW)/ GR - NSC 101-2314-B-182-004-MY3/Ministry of Science and Technology, Taiwan (TW)/ GR - CMRPG 3D1271-3/Chang Gung Memorial Hospital (TW)/ PT - Journal Article DEP - 20191128 PL - Netherlands TA - Qual Life Res JT - Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation JID - 9210257 SB - IM MH - Caregivers MH - Cerebral Palsy/*psychology MH - Child MH - Child, Preschool MH - Cognition/*physiology MH - Female MH - Follow-Up Studies MH - Humans MH - Infant MH - Male MH - *Minimal Clinically Important Difference MH - Netherlands MH - *Physical Functional Performance MH - Quality of Life/*psychology MH - Taiwan MH - Treatment Outcome OTO - NOTNLM OT - Cerebral palsy OT - Minimal clinically important differences OT - Quality of life OT - Responsiveness EDAT- 2019/11/30 06:00 MHDA- 2020/06/05 06:00 CRDT- 2019/11/30 06:00 PHST- 2019/11/19 00:00 [accepted] PHST- 2019/11/30 06:00 [pubmed] PHST- 2020/06/05 06:00 [medline] PHST- 2019/11/30 06:00 [entrez] AID - 10.1007/s11136-019-02370-y [pii] AID - 10.1007/s11136-019-02370-y [doi] PST - ppublish SO - Qual Life Res. 2020 Mar;29(3):825-831. doi: 10.1007/s11136-019-02370-y. Epub 2019 Nov 28.