PMID- 31782160
OWN - NLM
STAT- MEDLINE
DCOM- 20201008
LR  - 20201008
IS  - 1600-0560 (Electronic)
IS  - 0303-6987 (Linking)
VI  - 47
IP  - 2
DP  - 2020 Feb
TI  - Unusual subcutaneous dedifferentiated liposarcoma exhibiting coexistence of 
      meningothelial-like whorls and inflammatory myofibroblastic tumor-like 
      structures.
PG  - 171-178
LID - 10.1111/cup.13621 [doi]
AB  - To explore the clinicopathological features of a rare dedifferentiated 
      liposarcoma (DDLPS) with meningothelial-like whorls, we retrospectively analyzed 
      46 reported cases and 1 case that we encountered. Fluorescence in situ 
      hybridization (FISH) analysis of the MDM2 amplification status of our case was 
      also performed. Our case involved a 73-year-old male patient who had a mass in 
      the upper part of his left arm for 10 years and was treated by surgical ablation 
      of the tumor because of the mass' recent rapid enlargement. Microscopically, the 
      tumor tissues showed coexistence of well-differentiated and dedifferentiated 
      components, the latter of which included meningothelial-like whorls and 
      inflammatory myofibroblastic tumor-like structures. The dedifferentiated 
      components diffusely expressed vimentin, MDM2, CDK4, p16, and smooth muscle 
      actin. They were also focally positive for desmin but negative for S-100, CD117, 
      CD34, ALK, EMA, SOX-10, p53, and beta-catenin. FISH detection showed MDM2 
      amplification. In conclusion, subcutaneous DDLPS with meningothelial-like whorls 
      and inflammatory myofibroblastic tumor-like features is rare. This case broadens 
      the histopathological lineage of DDLPS, and confirms DDLPS with myogenic 
      differentiation. The use of the combination of MDM2, CDK4, p16, and FISH to 
      detect MDM2 amplification is a reliable basis for the diagnosis of DDLPS with 
      meningothelial-like whorls.
CI  - (c) 2019 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
FAU - Chen, Shuai
AU  - Chen S
AUID- ORCID: 0000-0002-3199-4162
AD  - Department of Pathology, Affiliated Hospital of Jining Medical University, 
      Jining, Shandong, China.
FAU - He, Shujin
AU  - He S
AD  - Department of Pathology, Affiliated Hospital of Jining Medical University, 
      Jining, Shandong, China.
AD  - Clinical College, Jining Medical University, Jining, Shandong, People's Republic 
      of China.
FAU - Huang, Haining
AU  - Huang H
AD  - Department of Pharmacy, Affiliated Hospital of Jining Medical University, Jining, 
      Shandong, People's Republic of China.
FAU - Li, Lei
AU  - Li L
AD  - Department of Pathology, Affiliated Hospital of Jining Medical University, 
      Jining, Shandong, China.
FAU - Wang, Wei
AU  - Wang W
AD  - Department of Pathology, Affiliated Hospital of Jining Medical University, 
      Jining, Shandong, China.
FAU - Cui, Zhihong
AU  - Cui Z
AD  - Department of Pathology, The Second People's Hospital of Jining, Jining, 
      Shandong, People's Republic of China.
FAU - Zhang, Renya
AU  - Zhang R
AD  - Department of Pathology, Affiliated Hospital of Jining Medical University, 
      Jining, Shandong, China.
LA  - eng
GR  - MP-2018-006/Miao Pu Project Foundation of Affiliated Hospital of Jining Medical 
      University/
GR  - JYFC2018FKJ015/Supporting Fund for Teachers' Research of Jining Medical 
      University/
PT  - Case Reports
DEP - 20191216
PL  - United States
TA  - J Cutan Pathol
JT  - Journal of cutaneous pathology
JID - 0425124
RN  - 0 (Neoplasm Proteins)
SB  - IM
MH  - Aged
MH  - *Gene Expression Regulation, Neoplastic
MH  - Humans
MH  - *Liposarcoma/metabolism/pathology
MH  - Male
MH  - *Myofibroblasts/metabolism/pathology
MH  - Neoplasm Proteins/*biosynthesis
MH  - *Skin Neoplasms/metabolism/pathology
MH  - Subcutaneous Tissue/metabolism/pathology
OTO - NOTNLM
OT  - CDK4
OT  - MDM2
OT  - dedifferentiated liposarcoma
OT  - fluorescence in situ hybridization
OT  - meningothelial-like whorls
EDAT- 2019/11/30 06:00
MHDA- 2020/10/09 06:00
CRDT- 2019/11/30 06:00
PHST- 2019/08/28 00:00 [received]
PHST- 2019/11/09 00:00 [revised]
PHST- 2019/11/26 00:00 [accepted]
PHST- 2019/11/30 06:00 [pubmed]
PHST- 2020/10/09 06:00 [medline]
PHST- 2019/11/30 06:00 [entrez]
AID - 10.1111/cup.13621 [doi]
PST - ppublish
SO  - J Cutan Pathol. 2020 Feb;47(2):171-178. doi: 10.1111/cup.13621. Epub 2019 Dec 16.