PMID- 31783804
OWN - NLM
STAT- MEDLINE
DCOM- 20200508
LR  - 20200508
IS  - 1471-2342 (Electronic)
IS  - 1471-2342 (Linking)
VI  - 19
IP  - 1
DP  - 2019 Nov 29
TI  - Ultrasound assessment of tensile stress in carotid arteries of healthy human 
      subjects with varying age.
PG  - 93
LID - 10.1186/s12880-019-0394-5 [doi]
LID - 93
AB  - BACKGROUND: Arterial remodeling is thought to reflect the adaptation of the 
      vessel wall to mechanical and hemodynamic stimuli and contributes to the 
      progression of cardiovascular and cerebrovascular diseases. Tensile stress (TS) 
      is one of the mechanical properties of the artery wall. The purpose of this study 
      was to investigate the tensile stress change (TS) of carotid artery with varying 
      viscoelasticity in healthy subjects within two groups of different ages. METHODS: 
      Forty-five subjects were recruited and randomly assigned into the group at the 
      age above 50 years and below 50 years. The carotid arteries were examined by 
      ultrasonography, using the techniques of shear wave elastography (SWE), shear 
      wave dispersion (SWD) and radiofrequency (RF) -based ultrasound. The following 
      values, including elastic modulus (SWER) and viscous index (SWDR), as well as the 
      peak and mean TS of the left and right carotid arteries (L-PTS, R-PTS, L-MTS and 
      R-MTS) were measured. The correlations between SWER, SWDR and tensile stress were 
      evaluated. RESULTS: The SWE(R) and SWD(R) of carotid arteries are lower in the 
      subjects >/=50 years old than the subjects younger than 50 years (SWE(R), 
      10.29 +/- 9.57 kPa VS 17.24 +/- 14.07 kPa; SWD(R,) 11.99 +/- 3.51 (m/s)/kHz VS 
      13.97 +/- 3.71 (m/s)/kHz, P < 0.05). The R-PTS was lower in the group with younger 
      age (P < 0.05). Pearson correlation analysis showed that SWE(R) of carotid artery 
      was positively correlated with the parameters of tensile stress, R-PTS, R-MTS, 
      L-PTS and L-MTS(r = 0.218, r = 0.359, r = 0.209 and r = 0.369, respectively, 
      P < 0.05). However, SWD(R) of carotid arteries was not significantly associated 
      with TS. CONCLUSION: Ultrasonic shear wave imaging could be used to 
      quantitatively assess carotid viscoelasticity. The carotid TS was related to its 
      elasticity while little related to its viscosity, suggesting that mechanical 
      properties of the arterial wall might be better revealed. TRIAL REGISTRATION: 
      Date of our trial registration: 2018-06-11. Registered with the official website 
      of China Clinical Trial Registration Center (ChiCTR1800016590).
FAU - Luo, Xianghong
AU  - Luo X
AD  - Department of Echocardiography, Shanghai General Hospital, Shanghai Jiao Tong 
      University School of Medicine, Shanghai, 200080, China.
FAU - Du, Lianfang
AU  - Du L
AD  - Department of Ultrasound, Shanghai General Hospital, Shanghai Jiao Tong 
      University School of Medicine, 100 Haining Road, Hongkou District, Shanghai, 
      200080, China.
FAU - Li, Zhaojun
AU  - Li Z
AD  - Department of Ultrasound, Shanghai General Hospital, Shanghai Jiao Tong 
      University School of Medicine, 100 Haining Road, Hongkou District, Shanghai, 
      200080, China. lzj_197506@126.com.
LA  - eng
SI  - ChiCTR/ChiCTR1800016590
PT  - Clinical Trial
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20191129
PL  - England
TA  - BMC Med Imaging
JT  - BMC medical imaging
JID - 100968553
SB  - IM
MH  - Adult
MH  - Age Factors
MH  - Aged
MH  - Carotid Arteries/*diagnostic imaging/*physiology
MH  - Elasticity Imaging Techniques
MH  - Female
MH  - Healthy Volunteers
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Random Allocation
MH  - *Tensile Strength
MH  - Ultrasonography
MH  - Viscosity
PMC - PMC6884773
OTO - NOTNLM
OT  - Carotid artery
OT  - Shear wave dispersion
OT  - Shear wave elastography
OT  - Tensile stress
OT  - Ultrasonography
OT  - Viscoelasticity
COIS- The authors declare that they have no competing interests.
EDAT- 2019/12/01 06:00
MHDA- 2020/05/10 06:00
PMCR- 2019/11/29
CRDT- 2019/12/01 06:00
PHST- 2019/08/23 00:00 [received]
PHST- 2019/11/08 00:00 [accepted]
PHST- 2019/12/01 06:00 [entrez]
PHST- 2019/12/01 06:00 [pubmed]
PHST- 2020/05/10 06:00 [medline]
PHST- 2019/11/29 00:00 [pmc-release]
AID - 10.1186/s12880-019-0394-5 [pii]
AID - 394 [pii]
AID - 10.1186/s12880-019-0394-5 [doi]
PST - epublish
SO  - BMC Med Imaging. 2019 Nov 29;19(1):93. doi: 10.1186/s12880-019-0394-5.