PMID- 31783924
OWN - NLM
STAT- MEDLINE
DCOM- 20200625
LR  - 20200625
IS  - 2072-1315 (Electronic)
IS  - 1606-0997 (Print)
IS  - 1606-0997 (Linking)
VI  - 38
IP  - 1
DP  - 2019 Nov 29
TI  - Predictors of mortality among adult people living with HIV/AIDS on antiretroviral 
      therapy at Suhul Hospital, Tigrai, Northern Ethiopia: a retrospective follow-up 
      study.
PG  - 37
LID - 10.1186/s41043-019-0194-0 [doi]
LID - 37
AB  - BACKGROUND: Ethiopia is striving to achieve a goal of "zero human immune 
      deficiency virus/acquired immune deficiency syndrome (HIV/AIDS)-related deaths." 
      However, little has been documented on the factors that hamper the progress 
      towards achieving this goal. Therefore, the ultimate aim of this study was to 
      determine predictors of mortality among adult people living with HIV/AIDS on 
      antiretroviral therapy (ART). METHODS: A retrospective follow-up study was 
      employed on all adult HIV/AIDS patients who started ART between January 1 and 
      December 30, 2010, at Suhul Hospital, Tigrai Region, Northern Ethiopia. Data were 
      collected by trained fourth-year Public Health students using a checklist. 
      Finally, the collected data were entered into SPSS version 16. Then after, 
      Kaplan-Meier curves were used to estimate survival probability, the log-rank test 
      was used for comparing the survival status, and Cox proportional hazards model 
      were applied to determine predictors of mortality. RESULTS: The median follow-up 
      period was 51 months (ranging between 1 and 60 months, inter-quartile range (IQR) 
      = 14 months). At the end of follow-up, 37 (12.5%) patients were dead. The 
      majority of these cumulative deaths, 19 (51.4%) and 29 (78.4%), occurred within 3 
      and 4 years of ART initiation respectively. Consuming alcohol (adjusted hazard 
      ratio (AHR) = 2.23, 95% CI = 1.15, 4.32), low body weight (AHR = 2.38, 95% CI = 
      1.03, 5.54), presence of opportunistic infections (AHR = 2.18, 95% CI = 1.09, 
      4.37), advanced WHO clinical stage (AHR = 2.75, 95% CI = 1.36, 5.58), and not 
      receiving isoniazid prophylactic therapy (AHR = 3.00, 95% CI = 1.33, 6.74) were 
      found to be independent predictors of mortality. CONCLUSION: The overall 
      mortality was very high. Baseline alcohol consumption, low body weight, advanced 
      WHO clinical stage, the presence of opportunistic infections, and not receiving 
      isoniazid prophylactic therapy were predictors of mortality. Strengthening 
      behavioral and nutritional counseling with close clinical follow-up shall be 
      given much more emphasis in the ART care and support program.
FAU - Misgina, Kebede Haile
AU  - Misgina KH
AD  - College of Health Sciences, Aksum University, P.O. Box 1010, Aksum, Ethiopia.
FAU - Weldu, Meresa Gebremedhin
AU  - Weldu MG
AD  - College of Health Sciences, Aksum University, P.O. Box 1010, Aksum, Ethiopia. 
      mere2010ec@yahoo.com.
FAU - Gebremariam, Tewodros Haile
AU  - Gebremariam TH
AD  - College of Health Science, Addis Ababa University, Addis Ababa, Ethiopia.
FAU - Weledehaweria, Negassie Berhe
AU  - Weledehaweria NB
AD  - College of Health Sciences, Aksum University, P.O. Box 1010, Aksum, Ethiopia.
FAU - Alema, Haileslasie Berhane
AU  - Alema HB
AD  - College of Health Sciences, Aksum University, P.O. Box 1010, Aksum, Ethiopia.
FAU - Gebregiorgis, Yosef Sibhatu
AU  - Gebregiorgis YS
AD  - College of Health Sciences, Aksum University, P.O. Box 1010, Aksum, Ethiopia.
FAU - Tilahun, Yonas Girma
AU  - Tilahun YG
AD  - Center of International Reproductive Health Training (CIRHT), Bahir Dar 
      University, Bahir Dar, Ethiopia.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20191129
PL  - Bangladesh
TA  - J Health Popul Nutr
JT  - Journal of health, population, and nutrition
JID - 100959228
RN  - 0 (Anti-HIV Agents)
SB  - IM
MH  - Acquired Immunodeficiency Syndrome/drug therapy/*mortality/virology
MH  - Adult
MH  - Anti-HIV Agents/*therapeutic use
MH  - Ethiopia/epidemiology
MH  - Female
MH  - Follow-Up Studies
MH  - *HIV
MH  - HIV Infections/drug therapy/*mortality/virology
MH  - Humans
MH  - Kaplan-Meier Estimate
MH  - Male
MH  - Proportional Hazards Models
MH  - Retrospective Studies
MH  - Risk Factors
PMC - PMC6883545
OTO - NOTNLM
OT  - ART
OT  - Ethiopia
OT  - HIV/AIDS
OT  - Mortality
OT  - Tigrai
COIS- The authors declare that they have no competing interests.
EDAT- 2019/12/01 06:00
MHDA- 2020/06/26 06:00
PMCR- 2019/11/29
CRDT- 2019/12/01 06:00
PHST- 2016/04/07 00:00 [received]
PHST- 2019/10/17 00:00 [accepted]
PHST- 2019/12/01 06:00 [entrez]
PHST- 2019/12/01 06:00 [pubmed]
PHST- 2020/06/26 06:00 [medline]
PHST- 2019/11/29 00:00 [pmc-release]
AID - 10.1186/s41043-019-0194-0 [pii]
AID - 194 [pii]
AID - 10.1186/s41043-019-0194-0 [doi]
PST - epublish
SO  - J Health Popul Nutr. 2019 Nov 29;38(1):37. doi: 10.1186/s41043-019-0194-0.